Brainstem Encephalitis and the Syndrome of Miller Fisher a Clinical Study

Al-Din, Amir Najim; Anderson, Milne; Bickerstaff, Edwin R.; Harvey, I. C.

doi:10.1093/brain/105.3.481

Cited by 188 publications

(94 citation statements)

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“…The clinical symptom of BBE is similar to that of FS, because of evidence of ophthalmoplegia, ataxia and CSF albuminocytological dissociation. Hence, BBE should be differentially diagnosed with FS (Al-Din et al, 1982). BBE must have consciousness disturbance or pyramidal signs, which reflect serious brainstem lesion.…”

Section: Discussionmentioning

confidence: 99%

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A case of overlapping Bickerstaff’s brainstem encephalitis and Guillain-Barré syndrome

Wang

Tang

Wang

2006

J. Zhejiang Univ. - Sci. B

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Abstract:Objective: There is no report on Bickerstaff's brainstem encephalitis (BBE) patients in China. We here report the first case of BBE in China. Methods: Clinical features, results of electromyography, electroencephalography (EEG), magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) examination were studied to clarify the characteristics of this syndrome. Results: A 44-year-old man presented himself at our inpatient department with somnolence and dizziness as his initial symptoms. He developed multiple cranial nerves paralysis especially internal and external ophthalmoplegia, ataxia and tetraparesis within 1 week. His condition rapidly deteriorated, and he experienced coma. Electromyography showed indications of peripheral nerve dysfunction, electroencephalography revealed loss of basic rhythm, MRI demonstrated high-intensity abnormalities on T 2 -weighted images of medulla oblongata, and CSF albuminocytological dissociation was defined abnormally as high protein. Ten months later, he almost completely recovered. Conclusion: BBE, fisher syndrome (FS) and Guillain-Barré syndrome (GBS) are similar clinically; BBE and FS were proposed to be the variant of GBS.

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Section: Discussionmentioning

confidence: 99%

“…Bickerstaff's brainstem encephalitis (BBE) is characterized by acute onset of ophthalmoplegia, ataxia, disturbance of consciousness, hyperreflexia or Babinski's sign (Bickerstaff, 1957;Al-Din et al, 1982). Most of the patients generally have a good outcome.…”

Section: Introductionmentioning

confidence: 99%

A case of overlapping Bickerstaff’s brainstem encephalitis and Guillain-Barré syndrome

Wang

Tang

Wang

2006

J. Zhejiang Univ. - Sci. B

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“…Controversy regarding the status arose when AI Din et al (1982) [5] in a study of 18 cases of Fisher's Syndrome reported an enhancing CT Scan lesion in brain stem in three cases and suggested that these cases form a distinct clinical entity. The brunt of the pathological process is in the brain stem rather than in peripheral nerves.…”

Section: Discussionmentioning

confidence: 99%

Fisher's Syndrome: A Case Report

Sharma

Gupta

Rana

et al. 2000

Medical Journal Armed Forces India

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“…While the anatomopathology of the lesions in MFS remains obscure [9], some authors have considered that these pathological lesions are localized in the peripheral nerves or nerve roots [2, 10]. Others have implicated an acute intra-axial and extraaxial inflammation in the midbrain [11, 12]or a combination of central brainstem and peripheral lesions [13]. Thus, the pathogenesis of MFS might be heterogeneous, and a spectrum may range between cases with pure brainstem involvement at one end, through cases presenting a combination of manifestations, to those with pure peripheral nerve involvement at the other [14].…”

Section: Discussionmentioning

confidence: 99%

Detection of Serum Anticerebellar Antibodies in Patients with Miller Fisher Syndrome

1999

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We performed Western blot analysis to detect anticerebellar antibodies in the serum of patients with Miller Fisher syndrome (MFS). We studied 7 MFS patients, 6 Guillain-Barré syndrome (GBS) patients and 10 normal healthy persons as controls. Six MFS patients (86%) had IgG antibodies against mouse cerebellar protein, whereas 3 GBS patients (50%) and 4 healthy controls (40%) had antibodies. The mean number of antibodies in the serum of patient with MFS was 2.43, which was significantly more than that of GBS patients (mean 0.67) and healthy control (mean 0.70). This finding suggests variability and complexity of target in nervous systems that suffer aberrant immunity in MFS, and may also reflect the variability and heterogeneity of the pathogenesis of this syndrome.

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Brainstem Encephalitis and the Syndrome of Miller Fisher a Clinical Study

Cited by 188 publications

References 0 publications

A case of overlapping Bickerstaff’s brainstem encephalitis and Guillain-Barré syndrome

A case of overlapping Bickerstaff’s brainstem encephalitis and Guillain-Barré syndrome

Fisher's Syndrome: A Case Report

Detection of Serum Anticerebellar Antibodies in Patients with Miller Fisher Syndrome

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