“…At the opposite, the first contribution of our work is to simultaneously integrate a very large set of characteristics so as to allow companies to easily use our framework for real-life problems. More precisely, we have simultaneously integrated in our framework the constraints separately studied in the following VRP subfields: Capacitated VRP (CVRP), VRP with Time Windows (VRPTW) (see, e.g., Bräysy and Gendreau, 2005;Cordeau et al, 2002;Kallehauge et al, 2005), VRP with heterogeneous fleet (see, e.g., Choi and Tcha, 2007;Seixas and Mendes, 2013), VRP with multi-trips and Split Deliveries (see, e.g., Archetti and Speranza, 2012;Dror et al, 1994;Salani and Vacca, 2011). Other constraints for variations like VRP with Backhauls or with Pickup and Delivery, VRP with multi-depots, Dial-A-Ride Problems are not included in our approach, even if it would be a natural and possible extension.…”