Branch retinal artery occlusion in the untreated contralateral eye following aflibercept injections during heparin treatment: Possible contribution of a heparin-induced thrombocytopenia-like condition

Nakao, Shintaro; Yoshimitsu, Makoto; Kaizu, Yoshihiro; Wada, Iori; Yamaguchi, Muneo; Sonoda, Koh Hei

doi:10.1016/j.ajoc.2019.100549

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…bildirdikleri olgu sunumunlarında heparinli diyalize giren ve diyabetik makula ödemi nedeniyle aflibercept uygulanan hastanın tedavi edilmeyen gözünde enjeksiyon sonrası birinci günde retinal arter dal tıkanıklığı tespit etmişler ve patogenezde HİT'yi sorumlu tutmuşlardır (Resim 3). [37] Heparin ile indüklenmiş trombositopeniyi sistemik enfeksiyon ve kullanılan ilaçlar nedeniyle ortaya çıkan trombositopeniden ayırmak çok önemlidir. Trombositopeni olgularının sadece %5 kadarını HİT olguları oluşturmaktadır.…”

Section: Heparinunclassified

Medications Damaging Vascular Bed or Causing Microvasculopathy / Occlusion-2: Pathogenesis, Diagnosis, and Treatment (Gemcitabine, Fludarabine, Oral contraceptives, Heparin, Cocaine)

2023

Güncel Retina (Current Retina)

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Retinal toxicity can be observed during treatment with many systemic drugs and addictive substances used today. The drugs show their effects on the retina by different mechanisms such as direct toxicity to the retina and retina pigment epithelium, crystalline retinopathy, photoreceptor dysfunction, cystoid macular edema, central serous chorioretinopathy, uveitic effects, and vascular dysfunction. Vascular dysfunction, which is an important subgroup, occurs due to the direct effect of drugs on endothelium, increase in prothrombotic factors, and formation of immunocomplex and vasoconstrictive effects. The primary step in the treatment is to cease the causative agent and replace it with an alternative. In addition, medical or intravitreal injection treatments should be applied according to the retinal vascular pathology.

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Section: Heparinunclassified

Medications Damaging Vascular Bed or Causing Microvasculopathy / Occlusion-2: Pathogenesis, Diagnosis, and Treatment (Gemcitabine, Fludarabine, Oral contraceptives, Heparin, Cocaine)

2023

Güncel Retina (Current Retina)

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Aflibercept/ranibizumab

2019

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Complete Resolution of Subretinal Fluid of the Fellow Eye After Aflibercept Injection in Wet Age-Related Macular Degeneration

Rouvas,

Theodossiadis,

Georgalas

et al. 2025

RETINAL Cases &Amp; Brief Reports

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Purpose: To present a case of a patient with bilateral wet age-related macular degeneration (AMD) who was unilaterally treated with intravitreal aflibercept injections (IAIs) and the disease status in the fellow eye ameliorated after an IAI. Methods: Retrospective case report. Results: A 72-year-old woman was diagnosed with wet and dry AMD in her right (OD) and left (OS) eye, respectively. In OD, treatment strategy comprised 3 monthly IAIs, followed by re-injections according-to-need, while optical coherence tomography (OCT) scans were performed before IAIs. One month after the second IAI, subretinal fluid developed in OS. One week later, an IAI was applied in OD; two days later the disease status in OS was assessed by fluorescein angiography and OCT. Surprisingly, in OS subretinal fluid completely resolved and fluorescein angiography did not detect leakage, highlighting the absence of an active choroidal neovascularization. The short interval between IAI and the resolution of exudative phenomena in the other eye is suggestive of a beneficial effect in the contralateral eye. Conclusion: Herein we showed that an IAI had an effect to the fellow untreated eye. Our observation is consistent with active aflibercept in the systemic circulation. To the best of our knowledge, no other report in literature has demonstrated this effect of aflibercept in wet AMD.

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Branch retinal artery occlusion in the untreated contralateral eye following aflibercept injections during heparin treatment: Possible contribution of a heparin-induced thrombocytopenia-like condition

Cited by 3 publications

References 23 publications

Medications Damaging Vascular Bed or Causing Microvasculopathy / Occlusion-2: Pathogenesis, Diagnosis, and Treatment (Gemcitabine, Fludarabine, Oral contraceptives, Heparin, Cocaine)

Medications Damaging Vascular Bed or Causing Microvasculopathy / Occlusion-2: Pathogenesis, Diagnosis, and Treatment (Gemcitabine, Fludarabine, Oral contraceptives, Heparin, Cocaine)

Aflibercept/ranibizumab

Complete Resolution of Subretinal Fluid of the Fellow Eye After Aflibercept Injection in Wet Age-Related Macular Degeneration

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