Branched-Chain Amino Acid Therapy for Spinocerebellar Degeneration: A Pilot Clinical Crossover Trial.

Mori, Nozomi; Adachi, Yoshiki; Takeshima, Takao; Kashiwaya, Yoshiaki; Okada, Akitsugu; Nakashima, Kenichiro

doi:10.2169/internalmedicine.38.401

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…[17][18][19] The mean values of LNG, ENV-AREA, and REC-AREA in EC sessions of the migraine group were significantly greater than in controls, however, the degree of abnormality of stabilometric parameters were smaller than the results of ataxic patients in the literature. 20,21 Because we examined patients with migraine headache without any clinically apparent ataxic symptoms during the headache-free period, it is reasonable that we found only small difference in migrainous patients compared with ataxic patients. Romberg quotients of all stabilometric parameters except L/E in the migraine group were significantly greater than in the controls.…”

Section: Discussionmentioning

confidence: 99%

Static stabilometry in patients with migraine and tension‐type headache during a headache‐free period

Ishizaki

Mori

Takeshima

et al. 2002

Psychiatry Clin Neurosci

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The vestibulospinal system was evaluated using a stabilometric method in patients with migraine and episodic tension-type headache during headache-free periods. Migraine patients often complain of dizziness or vertigo during headache attacks and some exhibit these symptoms between attacks. Computerized static stabilometry is a reliable and non-invasive technique to evaluate the equilibrium function in various diseases. The subjects consisted of 21 patients with migraine, 12 patients with episodic tension-type headache and, age-and sex-matched controls. We performed two sets of static stabilometric measurements with eyes open (EO) and eyes closed (EC) for 30 s. The averages of two sessions of the following six stabilometric parameters were used for the analysis: locus length (LNG), environmental area (ENV-AREA), rectangle area (REC-AREA), locus length per second, locus length per environ area (L/E), and root mean square area. Romberg quotients (EC/EO) of these six parameters were also analyzed. The mean values of LNG, ENV-AREA and REC-AREA in the EC session in the migraine group were significantly greater than those in the controls (P < 0.05, Mann-Whitney rank sum test). Romberg quotients of all stabilometric parameters except the L/E in the migraine group were significantly greater than in the controls. Patients with episodic tension-type headache did not show any differences in the stabilometric study from the controls. The present findings suggest that patients with migraine show a significant increase of the body sway during the EC session, which indicates an underlying dysfunction in the vestibulospinal system.

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Section: Discussionmentioning

confidence: 99%

Static stabilometry in patients with migraine and tension‐type headache during a headache‐free period

Ishizaki

Mori

Takeshima

et al. 2002

Psychiatry Clin Neurosci

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“…Interestingly, ALS has been associated with abnormal glutamate metabolism, and since branched-chain amino acids (BCAAs; e.g., l -leucine, l -isoleucine, and l -valine) can modify glutamate metabolism, these have been evaluated with respect to their therapeutic potential [ 49 ]. However, clinical studies have provided conflicting evidence with some studies reporting negative effects or a lack of efficacy [ 49 , 50 , 51 ], whereas others reported amelioration of ALS symptoms [ 52 , 53 ]. More recently, in vivo preclinical evidence suggests that BCAA, tryptophan, and particularly arginine and proline metabolic pathways are associated with disease progression [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

et al. 2020

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Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols’ bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin–hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin–hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications.

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“…Parkinsonian features, but not a true PD‐like phenotype, have also been described in patients with SCA1, SCA6, SCA12, SCA14, and SCA21 12, 29, 43–50…”

Section: Types Of Movement Disordersmentioning

confidence: 97%

Movement disorders in spinocerebellar ataxias

2011

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Autosomal dominant spinocerebellar ataxias (SCAs) can present with a large variety of noncerebellar symptoms, including movement disorders. In fact, movement disorders are frequent in many of the various SCA subtypes, and they can be the presenting, dominant, or even isolated disease feature. When combined with cerebellar ataxia, the occurrence of a specific movement disorder can provide a clue toward the underlying genotype. There are reasons to believe that for some coexisting movement disorders, the cerebellar pathology itself is the culprit, for example, in the case of cortical myoclonus and perhaps dystonia. However, movement disorders in SCAs are more likely related to extracerebellar pathology, and imaging and neuropathological data indeed show involvement of other parts of the motor system (substantia nigra, striatum, pallidum, motor cortex) in some SCA subtypes. When confronted with a patient with an isolated movement disorder, that is, without ataxia, there is currently no reason to routinely screen for SCA gene mutations, the only exceptions being SCA2 in autosomal dominant parkinsonism (particularly in Asian patients) and SCA17 in the case of a Huntington's disease-like presentation without an HTT mutation.

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Branched-Chain Amino Acid Therapy for Spinocerebellar Degeneration: A Pilot Clinical Crossover Trial.

Cited by 7 publications

References 10 publications

Static stabilometry in patients with migraine and tension‐type headache during a headache‐free period

Static stabilometry in patients with migraine and tension‐type headache during a headache‐free period

Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

Movement disorders in spinocerebellar ataxias

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