Branched Short-Chain Fatty Acids as Biological Indicators of Microbiota Health and Links with Anthropometry

Gut microbiome derived short chain fatty acids: Promising strategies in necrotising enterocolitis

“…Branched chain fatty acids (BCFAs): Although the main three SCFAs mentioned are considered the major components recognised as the primary products of carbohydrate fermentation by the gut microbiota, it's important to note that products of amino acid fermentation, such as isovalerate, isobutyrate, and 2-methylbutyrate, are also generated by gut bacteria. They have been linked to various health and disease outcomes, such as depression and obesity, among others ( Ramos Meyers et al., 2022 ; Salazar et al., 2022 ; Trefflich et al., 2021 ). These main products are the result of dietary protein metabolism, HMOs, and fermentation of the branched-chain amino acids (BCAA) leucine, valine, and isoleucine ( Macfarlane et al., 1992 ).…”

“…, Escherichia coli, Bacteroides spp ., Lactobacillus spp ., and Clostridium spp. ( Hong et al., 2017 ; Salazar et al., 2022 ).…”