Branchial cleft cyst carcinoma

Bradley, Paula T.; Bradley, Patrick J.

doi:10.1097/moo.0b013e32835cebde

Cited by 34 publications

(26 citation statements)

References 35 publications

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“…[43][44][45] Another confusing aspect to cystic nodal metastases, particularly when they occur in patients in whom clinical and radiographic evaluation does not find an obvious primary lesion, is that they may be mistaken as branchial cleft cysts or as carcinoma arising in a branchial cleft cyst. 46,47 The latter phenomenon is still reported today, but must be exceedingly rare. 47 In this day and age, in a cystic squamous carcinoma in the neck surrounded by organized lymphoid tissue should be considered metastatic SCC until proven otherwise.…”

Section: Cystic Nodal Metastases and Ciliated Cellsmentioning

confidence: 97%

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Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can!

Lewis

2017

Modern Pathology

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As the human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma epidemic has developed in the past several decades, it has become clear that these tumors have a wide variety of morphologic tumor types and features. For the practicing pathologist, it is critical to have a working knowledge about these in order to make the correct diagnosis, not to confuse them with other lesions, and to counsel clinicians and patients on their significance (or lack of significance) for treatment and outcomes. In particular, there are a number of pitfalls and peculiarities regarding HPV-related tumors and their nodal metastases that can easily result in misclassification and confusion. This article will discuss the various morphologic types and features of HPV-related oropharyngeal carcinomas, specific differential diagnoses when challenging, and, if established, the clinical significance of each finding.

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Section: Cystic Nodal Metastases and Ciliated Cellsmentioning

confidence: 97%

“…46,47 The latter phenomenon is still reported today, but must be exceedingly rare. 47 In this day and age, in a cystic squamous carcinoma in the neck surrounded by organized lymphoid tissue should be considered metastatic SCC until proven otherwise.…”

Section: Cystic Nodal Metastases and Ciliated Cellsmentioning

confidence: 97%

Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can!

Lewis

2017

Modern Pathology

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“…Cervical cystic metastasis remains a challenging issue for preoperative diagnosis, with an incidence ranging from 33% to 62% [ 10 ]. Cervical cystic diseases may be associated with BCC, BC, cervical cystic CUP, cystic necrotic schwannoma, lymph node with necrotic granulomatous inflammation, lymphangioma, venous malformation, lymphoma with cystic degeneration, metastatic papillary thyroid carcinoma [ 10 , 25 ], or malignant ectopic thyroid glands [ 26 , 27 ]. The diagnosis of BC remains controversial and excluding other potential similar presentations, such as cervical cystic CUP, is paramount.…”

Section: Discussionmentioning

confidence: 99%

“…However, these conditions are difficult to differentiate from each other by fine-needle aspiration (FNA), ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) [ 8 ]. Among these lesions, BCC is the most common, which results from the incomplete obliteration of the embryonal branchial apparatus and is lined by stratified squamous epithelium histologically [ 10 , 11 ]. Although BC are associated with cystic masses, there is much controversy surrounding such a diagnosis [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although BC are associated with cystic masses, there is much controversy surrounding such a diagnosis [ 12 , 13 ]. BC is an extremely rare disease, which was initially believed to be a malignant transformation of the epithelium within the branchial cyst walls [ 10 ]. In 1950, Martin et al [ 14 ] proposed strict diagnostic criteria for BC, which were later modified by Khafif et al in 1989 [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Cervical metastasis of gingival carcinoma misdiagnosed as branchiogenic carcinoma, a rare entity - report of a case and review of literature

Sun¹,

Chen²,

Sun³

et al. 2017

BMC Oral Health

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BackgroundA cervical cystic mass is associated with a number of pathologies that present with similar symptoms. These conditions are difficult to differentiate using fine-needle aspiration (FNA), ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI). Another dilemma in the differential diagnosis of cervical cystic masses is due to the controversies associated with the existence of branchiogenic carcinoma (BC). BC is an extremely rare disease that must be differentiated from other conditions presenting with cervical cystic masses, especially cystic metastasis from occult primary lesions.Case presentationWe present a case report of a right cervical cystic metastasis from a significantly small squamous cell carcinoma primary gingival lesion misdiagnosed as BC by histopathology. A 62-year-old female presented with a painless progressively enlarging cervical mass at the anterior edge of the sternocleidomastoid muscle in the right submandibular region. Preoperative MRI and US revealed a well-defined cystic round mass. Postoperative histological examination indicated BC. Positron emission tomography/computed tomography (PET/CT) revealed high 18F–FDG (18F 2-fluoro-2-deoxy-D-glucose) uptake in surgical regions with a SUV (standard uptake value) max 4.0 and ipsilateral nasopharynx with a SUVmax 4.4, without any distant metastasis. Pathologic results revealed nasopharyngeal lymphadenosis. Considering the low incidence of BC and the limitation of diagnosis in one institution, the patient was referred to another hospital. Physical examination detected a significantly small neoplasm (~3 mm diameter) in the right lower gingiva. Histopathological examination of the neoplasm revealed a well-differentiated squamous cell carcinoma. Surgery, including a partial mandibulectomy and modified neck dissection (neck level I–V and submental lymph nodes) were undertaken. Postoperative histopathological results revealed a well-differentiated squamous cell carcinoma of right lower gingiva and two metastatic lymph nodes in the 18 lymph nodes of level II. A month later, recurrence occurred in the right cervical level II. The patient was placed on postoperative concurrent chemo-radiotherapy and supportive care. The patient suffered from cachexia and survived for only six months after surgery.ConclusionsIn cases of cervical cystic masses that appear after the age of 40, clinicians should bear in mind that occult primary lesions should be excluded and examination of the gingiva should be undertaken. PET/CT has a limited role in identifying small occult primary lesions and a comprehensive physical examination must be carefully performed.

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Primary branchiogenic carcinoma: malignant degeneration of a branchial cyst, a case report

et al. 2020

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Background Primary branchiogenic carcinoma (PBC) is an extremely rare and poorly documented disease developed from a brachial cleft cyst. Case A 51‐year‐old patient was referred to our unit for an upper neck mass. PBC was confirmed in accordance with Kahfif's diagnostic criteria. Prophylactic selective neck dissection was performed in a second‐stage surgery to ensure the complete removal of the neoplasm. Branchiogenic origin with lymphoid tissue was confirmed in the “host cyst” after histological examination and no other tumors were found elsewhere. Regular follow up documented no relapse 12 months after surgery. Conclusions Although rare, PBC must be suspected in presence of cervical masses, especially in patients older than 40 years. A standardized treatment algorithm still lacks, but prophylactic selective neck dissection could be considered as the first line choice after the diagnosis has been confirmed.

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Branchial cleft cyst carcinoma

Cited by 34 publications

References 35 publications

Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can!

Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can!

Cervical metastasis of gingival carcinoma misdiagnosed as branchiogenic carcinoma, a rare entity - report of a case and review of literature

Primary branchiogenic carcinoma: malignant degeneration of a branchial cyst, a case report

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