Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice

Kappeler, Caroline; Saillour, Yoann; Baudoin, Jean-Pierre; Tuy, Françoise Phan Dinh; Alvarez, Chantal; Houbron, Christophe; Gaspar, Patricia; Hamard, Ghislaine; Chelly, Jamel; Métin, Christine; Francis, Fiona

doi:10.1093/hmg/ddl062

Cited by 146 publications

(135 citation statements)

References 24 publications

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“…However, current evidence suggests that many of these mutants display defects in both modes of migration (McManus et al, 2004;Kappeler et al, 2006;this study). Impairment in the migration, disposition, and proper integration of interneurons in the cortical circuitry may explain, at least in part, the epilepsy and mental retardation observed in lissencephaly.…”

Section: Cortical Interneurons In Dclk and DCX Mutant Micementioning

confidence: 89%

“…Branching defects have also been reported for migrating interneurons taken from Dcx knock-out mice, leading to disorganized migration (Kappeler et al, 2006). Interestingly, these authors did not observe any differences in speed or distance of migration, but they used explant cocultures and fluorescent dyes on brain slices to assess migratory dynamics of interneurons.…”

Section: Interneuron Migration Is Delayed After DCX Rnaimentioning

confidence: 97%

“…Furthermore, one of these studies (Kappeler et al, 2006) reported no abnormalities in the number and distribution of cortical interneurons in Dcx mutants at different prenatal and postnatal ages. Here, we examined the Dcx Ϫ/y , Dclk…”

Section: Cortical Interneurons In Dclk and DCX Mutant Micementioning

confidence: 99%

“…Recent studies have reported that Dcx or Dclk single knock-outs do not show any apparent malformations of the cortex (Corbo et al, 2002;Deuel et al, 2006;Kappeler et al, 2006;Koizumi et al, 2006a). Furthermore, one of these studies (Kappeler et al, 2006) reported no abnormalities in the number and distribution of cortical interneurons in Dcx mutants at different prenatal and postnatal ages.…”

Section: Cortical Interneurons In Dclk and DCX Mutant Micementioning

confidence: 99%

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Both Doublecortin and Doublecortin-Like Kinase Play a Role in Cortical Interneuron Migration

Friocourt¹,

Liu²,

Antypa³

et al. 2007

J. Neurosci.

137

119

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Type I lissencephaly, a genetic disease characterized by disorganized cortical layers and gyral abnormalities, is associated with severe cognitive impairment and epilepsy. Two genes, LIS1 and doublecortin (DCX), have been shown to be responsible for a large proportion of cases of type I lissencephaly. Both genes encode microtubule-associated proteins that have been shown to be important for radial migration of cortical pyramidal neurons. To investigate whether DCX also plays a role in cortical interneuron migration, we inactivated DCX in the ganglionic eminence of rat embryonic day 17 brain slices using short hairpin RNA. We found that, when DCX expression was blocked, the migration of interneurons from the ganglionic eminence to the cerebral cortex was slowed but not absent, similar to what had previously been reported for radial neuronal migration. In addition, the processes of DCX-deficient migrating interneurons were more branched than their counterparts in control experiments. These effects were rescued by DCX overexpression, confirming the specificity to DCX inactivation. A similar delay in interneuron migration was observed when Doublecortin-like kinase (DCLK), a microtubuleassociated protein related to DCX, was inactivated, although the morphology of the cells was not affected. The importance of these genes in interneuron migration was confirmed by our finding that the cortices of Dcx, Dclk, and Dcx/Dclk mutant mice contained a reduced number of such cells in the cortex and their distribution was different compared with wild-type controls. However, the defect was different for each group of mutant animals, suggesting that DCX and DCLK have distinct roles in cortical interneuron migration.

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Section: Cortical Interneurons In Dclk and DCX Mutant Micementioning

confidence: 89%

Section: Interneuron Migration Is Delayed After DCX Rnaimentioning

confidence: 97%

Section: Cortical Interneurons In Dclk and DCX Mutant Micementioning

confidence: 99%

Section: Cortical Interneurons In Dclk and DCX Mutant Micementioning

confidence: 99%

See 2 more Smart Citations

Both Doublecortin and Doublecortin-Like Kinase Play a Role in Cortical Interneuron Migration

Friocourt¹,

Liu²,

Antypa³

et al. 2007

J. Neurosci.

137

119

View full text Add to dashboard Cite

show abstract

“…Several members of the microtubulestabilizing proetein family, such as microtubule-associated proteins and doublecortin (DCX), are essential for the early phase of neuronal migration [53][54][55][56][57]. Reduction in DCX also attenuates the transition of multipolar neurons to bipolar ones in the developing cortex [54,58].…”

Section: Fgf1functions In Neural Developmentmentioning

confidence: 99%

Roles of intracellular fibroblast growth factors in neural development and functions

Liu

et al. 2012

Sci. China Life Sci.

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Fibroblast growth factors (FGFs) can be classified as secretory (FGF1-10 and FGF15-23) or intracellular non-secretory forms (FGF11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be explored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neurons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A recent study showed that FGF13 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases. fibroblast growth factors, nervous system, development, microtubule, ion channel, X-linked mental retardation Citation:Zhang X, Bao L, Yang L, et al. Roles of intracellular fibroblast growth factors in neural development and functions.

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Cortical Neuron Migration in Health and Disease

Javier‐Torrent,

Nguyen

2023

Neocortical Neurogenesis in Development and Evolution

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Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice

Cited by 146 publications

References 24 publications

Both Doublecortin and Doublecortin-Like Kinase Play a Role in Cortical Interneuron Migration

Both Doublecortin and Doublecortin-Like Kinase Play a Role in Cortical Interneuron Migration

Roles of intracellular fibroblast growth factors in neural development and functions

Cortical Neuron Migration in Health and Disease

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