The article investigates the possibilities of re-activating the built heritage of the Marche Apennine through shared, creative, and transcalar approaches. This is a particularly challenging task for marginal inner areas, which during the pandemic have been even more isolated due to previous structural issues such as lack of services, poor accessibility, economic stagnation, and depopulation. Italian inner areas are also facing an increase in environmental risks linked to ongoing climate change. This work focuses on the Appennino Basso Pesarese Anconetano in the Marche Region as part of the national project “Branding4Resilience”. The research methodological approach entails an exploration of the territory through quantitative and qualitative tools to investigate the possibility of a new reading of the Marche inner area and suggest operation at a local level, without losing the wider perspective on global challenges. This interpretation is synthesized in a territorial portrait that supports visions for the sustainable transformation of the area, and shows the need for shared collaborative approaches for more inclusive forms of living together. Finally, the work proposes built heritage as a trigger for development processes in marginalized territories, thus highlighting the crucial role of design and creativity, through transcalar approaches, to unveil relevant and often hidden resources and to envisage resilient futures for inner areas.