Branhamella catarrhalis Keratitis

Heidemann, David G.; Alfonso, Eduardo C.; Forster, Richard K.; Ullman, Saul; Holland, Simon; Mendelsohn, Alan D.; Miller, Darlene

doi:10.1016/s0002-9394(14)74282-5

Cited by 13 publications

(3 citation statements)

References 14 publications

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“…Other studies have also found Moraxella keratitis to be associated with chronic alcoholism, malnutrition, and poor sanitary habits. [19][20][21] It is beyond the scope of this study to perform subgroup analysis on these two groups of patients. With the observed change in trend, high clinical suspicion for Moraxella keratitis is required especially in older patients with systemic comorbidities as the infection can appear clinically similar to Pseudomonas but may require a different antibiotic regime.…”

Section: Discussionmentioning

confidence: 99%

Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital

Tan

Walkden

et al. 2017

Eye

104

114

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PurposeTo investigate the frequencies, trends, and in vitro drug susceptibilities of the causative pathogens in microbial keratitis in Manchester Royal Eye Hospital.Patients and methodsCorneal scrape results recorded by the microbiology service between 2004 and 2015 were extracted from an established database. A total of 4229 corneal scrape specimens were identified from an established database. First-line antibiotic treatment in our centre during the study period was ofloxacin and second line was cefuroxime and gentamicin.ResultsMean age was 45.9±21.0. A total of 1379 samples (32.6%) were culture positive. One hundred forty-eight (10.7%) specimens cultured multiple organisms. Of the 1539 organisms identified, 63.3% were Gram-positive bacteria, 27.3% Gram-negative bacteria, 7.1% fungi, and 2.3% Acanthamoebae. A decreasing trend in Gram-positive isolates was found together with a stable trend in Gram negatives and an increasing trend in Acanthamoeba and fungi. There appeared to be a significant increasing trend of Moraxella infection (P=0.001). In all, 83.1 and 90.8% of Gram-positive and -negative isolates tested were susceptible to ofloxacin, respectively. Cefuroxime covered 86.6% of Gram-positive and 61.4% of Gram-negative isolates, whereas gentamicin covered 88.8 and 96.5% of Gram-positive and -negative isolates, respectively.ConclusionWe found a change in the type of Gram-negative organisms isolated over time, with the Moraxella species on the rise. Reassuringly, no significant increase in resistance was observed in vitro for any of the commonly used antibiotics. Ofloxacin remains a good first-line antibiotic treatment but duo-therapy does have broader coverage and should be considered in non-responsive cases.

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Section: Discussionmentioning

confidence: 99%

Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital

Tan

Walkden

et al. 2017

Eye

104

114

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“…described ten cases which had predisposing ocular or systemic conditions. (Heidemann et al. 1987) However, Das et al.…”

Section: Outcomes Of 21 Patients With Moraxella Keratitis Examined Amentioning

confidence: 99%

Moraxella keratitis: risk factors, presentation, and management

Malta

2011

Acta Ophthalmologica

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“…M. catarrhalis appears to be isolated less frequently from sinusitis than S. pneumoniae and H. influenzae, being found in approximately 10% of isolates, primarily in episodes of acute sinusitis [48,49]. Occasionally, M. catarrhalis also may be associated with non-respiratory tract-related diseases, including bacteremia [50], mastoiditis [51], endocarditis [52], ventriculitis [53], conjunctivitis [54], keratitis [55], ophthalmia neonatorum [56], septic arthritis [57], meningitis [58], pericarditis [59], osteomyelitis [60] and even acute urethritis [61].…”

Section: Diseasementioning

confidence: 99%

Moraxella catarrhalis: A mini review

Hays

2015

J Pediatr Infect Dis

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Moraxella catarrhalis is a human-specific bacterium previously discounted as a simple commensal organism with only limited pathogenic potential. This view has changed considerably and we now know that M. catarrhalis is associated with a range of disease states affecting both children and adults. In particular, M. catarrhalis tends to be associated with upper respiratory tract infections, including otitis media and sinusitis in children and lower respiratory tract infections in adults with pre-existing pulmonary disease, e.g., exacerbations of chronic obstructive pulmonary disease. Colonization with this bacterium is especially common in infants and young children, the age group most affected by M. catarrhalis-mediated disease. Research is just beginning to unravel the complex interaction between this pathogen and the human host and is providing insights into its diverse genetic population structure and numerous virulence traits. These latter markers include multiple potential cellular adhesion molecules that are currently being researched as potential vaccine candidates. This mini-review is intended to provide the reader with a short introduction to M. catarrhalis as a pathogen and includes recent advances in the understanding of mechanisms associated with bacterial virulence.

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Branhamella catarrhalis Keratitis

Cited by 13 publications

References 14 publications

Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital

Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital

Moraxella keratitis: risk factors, presentation, and management

Moraxella catarrhalis: A mini review

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