Brauner Urin

Pietsch, Urs; Müller-Höcker, Christina; Filipovic, Miodrag

doi:10.1007/s00101-016-0171-6

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Nevertheless, patients with cardiovascular diseases would take several medicines which can result in combined adverse drug reaction. There were several studies reported about drug combination reaction caused rhabdomyolysis between simvastatin and amiodarone, which simvastatin is metabolized by CYP3A4 and amiodarone is a CYP3A4 inhibitor (Roten et al, 2004;Schmidt et al, 2007;Pietsch et al, 2016). The reaction could lead to secondary acute renal failure.…”

Section: Blood Chemistry Monitoringmentioning

confidence: 99%

Effects of amiodarone and dronedarone on heart rate variability, cardiac contractility, and thyroid hormone levels in rabbits

Boonhoh

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Amiodarone (AM) and dronedarone (DR) are class III antiarrhythmic agents that have similar chemical structures, except AM contains iodine molecules. Due to the limited data available in rabbits, the effects of both drugs on heart rate variability (HRV), contractility and thyroid hormone levels were studied. Sixteen male New Zealand white rabbits were used and divided into 2 groups received AM or DR. The rabbits were gavaged either AM or DR at dosages of 50 (AM50, DR50) and 100 mg/kg/day (AM100, DR100) continuously for a period of 7 days each. On the last day of each period, electrocardiograms were recorded from the conscious rabbits, while standard echocardiograms (Echo), speckle tracking echocardiograms (STE) and blood samples were collected from the anesthetized rabbits afterward. The HRV results showed that AM100 and DR100 decreased heart rate, total power, low frequency component, and low to high frequency ratio significantly compared to the baselines. All echocardiographic parameters of both agents in every period were no significant difference from their baselines, except global circumferential plane strain rate at basal segmental level of AM50 that was decreased. Thyroxine levels were significantly increased in AM treatments but decreased in DR treatments of treatment period 1 and 2 compared to their baseline. In conclusion, both AM and DR reduce HRV which may be due to sympathetic suppression. STE may provide more information but not give higher sensitivity than Echo in our study, despite the fact that AM may have more negative inotropic effect than DR in this model. Nevertheless, both drugs produced thyroid dysfunction in the different way, thyrotoxicosis in AM but hypothyroidism in DR.

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Section: Blood Chemistry Monitoringmentioning

confidence: 99%

Effects of amiodarone and dronedarone on heart rate variability, cardiac contractility, and thyroid hormone levels in rabbits

Boonhoh

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Amiodarone/simvastatin interaction

2016

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Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects

et al. 2017

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Arterial hypertension and dyslipidemia is a very frequent comorbid condition. Arterial hypertension and dyslipidemia are combined in 40-70% of patients. The statins is the basic drug in primary and secondary prevention of cardiovascular disease and in the reduction of cardiovascular complications. We`ve attempted to summarize some data about the statins and interaction of antihypertensive drugs. Rosuvastatin is a medicine that provides an intensive reduction of low-density lipoproteins, does not require dose adjustment when applied in conjunction with antihypertensive drugs. The absence of inhibition and activation of rosuvastatin cytochrome P450 provides a low risk of negative interactions in the clinical situations of induced polypharmacy. Every clinician is to remember that it`s crucial to take into account some adverse reactions combining the statins with drugs of other pharmacological groups.

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Brauner Urin

Cited by 3 publications

References 6 publications

Effects of amiodarone and dronedarone on heart rate variability, cardiac contractility, and thyroid hormone levels in rabbits

Effects of amiodarone and dronedarone on heart rate variability, cardiac contractility, and thyroid hormone levels in rabbits

Amiodarone/simvastatin interaction

Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects

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