Brazilian Gastric Cancer Association Guidelines (Part 1): An Update on Diagnosis, Staging, Endoscopic Treatment and Follow-Up

Barchi, Leandro Cardoso; Ramos, Marcus Fernando Kodama Pertille; Yagi, Osmar Kenji; Mucerino, Donato Roberto; Bresciani, Cláudio José Caldas; Júnior, Ulysses Ribeiro; Andreollo, Nelson Adami; Assumpção, Paulo Pimentel de; Weston, Antônio Carlos; Colleoni, Ramiro; Zilberstein, Bruno; members, Consensus panel; Ferraz, A.; Charruf, Amir Zeide; Dias, André Roncon; Brandalise, André; Silva, André Maciel da; Alves, Barlon; Malheiros, Carlos Alberto; Marins, Carlos Augusto Martinez; Leite, Celso Vieira de Souza; Szor, Daniel José; Wohnrath, Durval R.; Ilias, Elias Jirjoss; Filho, Euclides Dias Martins; Lopasso, Fabio Pinatel; Coimbra, Felipe José Fernández; Felippe, F.; Tomasisch, Flávio Daniel Saavedra; Takeda, Flávio Roberto; Ishak, Geraldo; Laporte, Gustavo Andreazza; Silva, Herbeth José Toledo; Ivan, Cristina; Rodrigues, Joaquim José Gama; Grande, José Carlos Del; Lourenço, Laércio Gomes; Motta, Leonardo Milhomem da; Ferraz, Leonardo Rocha; Moreira, Luís Fernando; Lopes, Luis Roberto; Toneto, Marcelo Garcia; Mester, Marcelo; Rodrigues, Marco Antônio Gonçalves; Carvalho, Marineide Prudêncio de; Franciss, Maurice; Forones, Nora Manoukian; Corletta, Oly Campos; Castro, Osvaldo Antonio Prado; Malafaia, Osvaldo; Kassab, P; Savassi-Rocha, Paulo Roberto; Oliveira, Rodrigo José de; Sallun, Rubens Antonio Aissar; Weschenfelder, Rui; Oliveira, Saint Clair Vieira de; Abreu, Thiago Boechat de; Castria, Tiago Biachi De; Barra, Williams Fernandes; Júnior, Wilson Luiz da Costa; Júnior, Wilson Rodrigues de Freitas

doi:10.1590/0102-672020200003e1535

Cited by 13 publications

(9 citation statements)

References 41 publications

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“…The incidence and statistics of malignant tumors of the esophagus, stomach, and colorectal in the Brazilian population are high and significant 1 , 15 , 29 . The most frequent malignant esophageal tumors are squamous cell carcinomas, followed by adenocarcinomas, which affect the esophagogastric junction.…”

Section: Discussionmentioning

confidence: 99%

“…Patients looking for medical help present these tumors in an advanced form; so it is important to implement specific health actions to provide orientations to the population, encouraging the early search for Medical Services and requesting these endoscopic examinations, for the diagnosis the tumors in early stages. The diagnosis of these tumors in early and non-advanced stages allows greater chances of surgical and oncological treatments, making possible better disease control and increased survival and quality of life 1 , 14 , 29 .…”

Section: Discussionmentioning

confidence: 99%

“…Walter de Biase SILVA-NETO 1 , Claudemiro QUIRESE 1 , Eduardo Guimarães Horneaux de MOURA 2 , Fabricio Ferreira COELHO 3 , Paulo HERMAN 3 ABSTRACT -Background: The treatment of choice for patients with schistosomiasis with previous episode of varices is bleeding esophagogastric devascularization and splenectomy (EGDS) in association with postoperative endoscopic therapy. However, studies have shown varices recurrence especially after long-term follow-up.…”

Section: A Queda Da Pressão Portal Após Desvascularização Esofagogást...mentioning

confidence: 99%

“…In Brazil, as in North America, Europe, and some countries in Asia, esophagus, stomach, and colorectal malignant tumors are among the most frequent cancer in the population, in both sexes, becoming a public health problem, since they involve health services, hospital, and outpatient clinics, of medium and high complexity 1 , 4 , 12 , 29 .…”

Section: Introductionmentioning

confidence: 99%

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The Esophageal, Gastric, and Colorectal Tumors and the Esophagogastroduodenoscopies and Colonoscopies by the Brazilian Unified Health System: What Is the Importance?

Risso

Costa

Tercioti

et al. 2022

ABCD, arq. bras. cir. dig.

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- BACKGROUND: Esophagogastroduodenoscopies and colonoscopies are the main diagnostic examinations for esophageal, stomach, and colorectal tumors. AIM: This study aimed to evaluate the estimates of the incidence of esophageal, stomach, and colorectal cancer; population growth; and esophagogastroduodenoscopies and colonoscopies performed by the Unified Health System (SUS), from 2010 to 2018, in the five regions of the country, and to analyze the relationship between these values. RESULTS: The colorectal tumor had a significant elevation, while the esophageal and gastric maintained the incidences. In the five regions, there was a significant increase in the number of colonoscopies; however, this increase did not follow the increase in the population in the North and Northeast regions. There was no significant increase in the number of esophagogastroduodenoscopies in the North, Northeast, Midwest, and South regions, and in the North region there was a decrease. In the Northeast region, there was a decreasing number, and in the South and Midwest regions, the number of examinations remained stable in the period. The Southeast region recorded an increase in the number of examinations following the population growth. CONCLUSION: The current number of esophagogastroduodenoscopies and colonoscopies performed by the SUS did not follow the population growth, in order to attend the population and diagnose esophageal, stomach, and colorectal tumors. Therefore, the country needs to have adequate and strategic planning on how it will meet the demand for these tests and serve the population well, incorporating new technologies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: A Queda Da Pressão Portal Após Desvascularização Esofagogást...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Esophageal, Gastric, and Colorectal Tumors and the Esophagogastroduodenoscopies and Colonoscopies by the Brazilian Unified Health System: What Is the Importance?

Risso

Costa

Tercioti

et al. 2022

ABCD, arq. bras. cir. dig.

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“…14 The extent of the gastric resection (subtotal vs total) and the lymphadenectomy followed the recommendations of the Japanese Gastric Cancer Association (JGCA) and the Brazilian National Consensus on GC. 3,15 Only MVRs performed for direct tumor invasion were included. R0 is defined as microscopic tumor-free margins.…”

Section: Methodsmentioning

confidence: 99%

Multivisceral resection compared to standard gastrectomy for gastric adenocarcinoma: A propensity score‐matching analysis

Dias

Pereira

Ramos

et al. 2022

Journal of Surgical Oncology

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Background: Multivisceral resection (MVR) in locally advanced gastric cancer (GC) is a morbid procedure. However, the precise impact of removing additional organs remains controversial. This study aimed to compare the outcomes of MVR versus standard gastrectomy (SG) in an unbiased cohort.Methods: Patients who underwent curative-intent surgery for gastric adenocarcinoma were considered. Those submitted to SG were compared to the ones who received MVR using Propensity Score Matching (PSM) analysis.Results: A total of 685 GC patients were included (621 SG and 64 MVR). Groups were distinct concerning the extent of the gastrectomy, tumor size, pTNM, R0, postoperative complications, and 90-day mortality. After PSM, 57 patients were matched in each group. All variables assigned in the score were well matched.Postoperative complication, 90-day mortality, and overall survival (OS) became similar among groups. Age >65 years old and resection of two or more organs, besides the stomach, were factors associated with 90-day mortality. R1 and not received multimodal therapy were independent prognostic factors for worse OS.Conclusions: After PSM, the difference in morbidity, mortality, and survival of MVR compared to SG was no longer statistically significant, suggesting that MVR is an acceptable therapeutic strategy to patients with advanced GC.

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Adjuvant chemotherapy versus preoperative chemotherapy for gastric cancer treated with curative‐intent resection: A propensity score‐matched analysis

Pereira,

Ramos,

Dias

et al. 2024

Journal of Surgical Oncology

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BackgroundMultimodal therapy (MMT), comprising surgery alongside perioperative chemotherapy (PCMT) or adjuvant chemotherapy (ACMT), has demonstrated improve in survival compared with surgery alone for advanced gastric cancer (GC). However, the moment of administering chemotherapy for GC is still a matter of debate. This study aimed to compare PCMT and ACMT in patients with locally advanced GC.MethodWe included all gastric adenocarcinoma treated with chemotherapy and curative‐intent resection. Using propensity score matching (PSM), patients who received PCMT were matched with patients undergoing ACMT for 10 pretreatment variables.ResultsAmong the 552 patients with indication for MMT, 377 (68.3%) received combining chemotherapy (CMT): 116 (30.8%) PCMT and 261 (69.2%) ACMT. After PSM, 109 patients were matched in each group. All variables assigned in the score were well matched and both groups became equivalent. Patients receiving PCMT had less angiolymphatic and perineural invasion, less advanced pT, pN and pTNM stage than ACMT group (p < 0.001 for all). There was no difference in the postoperative complication rate between both groups (p = 0.551). After the matching, disease‐free survival (DFS) and overall survival (OS) became similar between PCMT and ACMT groups (DFS: 51.4% vs. 46.9%, p = 0.882, respectively; OS: 54.3% vs. 48.7%, p = 0.638, respectively).ConclusionAfter controlling for pretreatments characteristics, there was no significant difference in survival between GC patients who underwent perioperative and adjuvant CMT. PCMT did not result in an increase in survival, but it provides a decrease in the stage of the disease, with no difference in surgical outcomes.

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Brazilian Gastric Cancer Association Guidelines (Part 1): An Update on Diagnosis, Staging, Endoscopic Treatment and Follow-Up

Cited by 13 publications

References 41 publications

The Esophageal, Gastric, and Colorectal Tumors and the Esophagogastroduodenoscopies and Colonoscopies by the Brazilian Unified Health System: What Is the Importance?

The Esophageal, Gastric, and Colorectal Tumors and the Esophagogastroduodenoscopies and Colonoscopies by the Brazilian Unified Health System: What Is the Importance?

Multivisceral resection compared to standard gastrectomy for gastric adenocarcinoma: A propensity score‐matching analysis

Adjuvant chemotherapy versus preoperative chemotherapy for gastric cancer treated with curative‐intent resection: A propensity score‐matched analysis

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