Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway

Abstract

Although propolis induces apoptosis mainly by p53-independent manner, it may be induced by another pathway, and new insights may arise for preventing or treating lung cancer.

Mechanisms involved in the cytotoxic action of Brazilian propolis and caffeic acid against HEp-2 cells and modulation of P-glycoprotein activity

“…It is well known that apoptosis and cell cycle deregulation are closely related events; however, disruption of cell cycle progression may lead to apoptotic/necrotic death, suggesting that both types of cell death may be useful in cancer therapy . Our results are in agreement with previous investigation showing that Brazilian green propolis inhibited different cancer cells by inducing apoptosis …”

Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species

“…Apoptosis is one of important mechanisms by which various agents exhibit their anticancer effects . In this study, the apoptosis‐inducing effect of luteolin on CCA cells was observed by the fluorescent dye AO/EB staining and flow cytometry with annexin V/PI staining.…”

Antiproliferative Activity of Chemically Characterized Propolis from Turkey and Its Mechanisms of Action

“…There are several studies indicating apoptotic effect of propolis from various origins on various cancer cell lines. [2,3,17] In one of these studies published by Frión-Herrera et. al., authors revealed that Brazilian green propolis induced apoptosis via a p53-independent way on A549 cells.…”

“…[1] Among these bioactivities, cytotoxic and anticancer activities of propolis have particularly attracted much attention in recent years. [2][3][4][5] Carcinogenesis is a multistage process; involving initiation, promotion and progression. During cell division, maintenance of tissue homeostasis, integrity of nuclear material and cell size in under control of cell cycle checkpoints.…”