Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet

Abstract

Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption.

Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High‐Fat Diet‐Fed Mice

“…No modification of energy expenditure was observed under propolis supplementation, but an increase of fecal lipids was observed, suggesting that Brazilian propolis reduced intestinal fat absorption. [13] The molecular mechanism(s) underlying the effect of propolis on weight gain limitation remains elusive. B) 3T3-L1 adipocytes were incubated with growing concentrations of PPEE for 24 h. Expression of Nrf2-target genes coding for antioxidant enzymes measured through qPCR and expressed relative to 18S ribosomal RNA.…”

“…No modification of energy expenditure was observed under propolis supplementation, but an increase of fecal lipids was observed, suggesting that Brazilian propolis reduced intestinal fat absorption. [ 13 ] The molecular mechanism(s) underlying the effect of propolis on weight gain limitation remains elusive.…”

“…Preclinical studies have been performed in animal models of obesity and/or diabetes, to investigate the phenotypical impact of propolis supplementation in the diet. [12][13][14][15][16][17] The molecular mechanisms underlying the observed effects in terms of obesity management and improvement of glucose homeostasis, however, still remain unclear. Thus, the aim of the present study was to evaluate the effect of a standardized poplar propolis ethanolic extract (PPEE) on obesity glucose homeostasis and the physiology of the adipose tissue in high-fat diet-fed mice.…”

Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice

“…Although several reports have demonstrated that Brazilian green propolis extracts have hypoglycemic effects [26,27], there are no reports on the influence of treatment with baccharin alone in vivo. In the present animal study, we investigated the effects of baccharin on glucose metabolism and insulin sensitivity in obese diabetic ob/ob mice.…”

Propolis: Chemical Constituents, Plant Origin, and Possible Role in the Prevention and Treatment of Obesity and Diabetes

“…The authors presumed this effect was due to a reduction of fat absorption by propolis because they observed increased excretion of fat into the feces. 82 Not all studies have used Brazilian green propolis. One study showed that administration of an ethanol extract of Croatian propolis (50 mg/kg) for 30 days significantly attenuated weight gain in a mouse model of diet-induced obesity.…”