Brazilian guidelines for allergen immunotherapy in the treatment of allergic rhinitis

Brazilian Guidelines to Allergen Immunotherapy for Patients with Allergic Rhinitis: Position Statement of the Brazilian Association of Allergy and Immunology (ASBAI)

“…The initial database search yielded approximately 1,200 articles, of which only 47 met the inclusion criteria. 2 Twenty-five of them were doubleblind, randomized, placebo-controlled trials, including a total of 4,518 patients with perennial allergic rhinitis, with or without associated asthma, and 3,887 placebotreated control patients. The data obtained were assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to assign levels of evidence (high, moderate, low, and very low) and rate the strength of the recommendations (weak or strong).…”