Brazilian Society of Hepatology and Brazilian College of Radiology practice guidance for the use of elastography in liver diseases

Cardoso, Ana Carolina; Villela-Nogueira, Cristiane Alves; Figueiredo-Mendes, C.; Filho, Hilton Leão; Silva, Rogério Augusto Pinto; Tovo, Cristiane Valle; Perazzo, Hugo; Matteoni, Antonio Carlos; Carvalho-Filho, Roberto José de; Bittencourt, Paulo Lisboa

doi:10.1016/j.aohep.2021.100341

Cited by 4 publications

(2 citation statements)

References 106 publications

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“…Procedures were considered reliable and included in the analysis only when they presented at least 10 valid shots, a success rate of at least 60%, and an interquartile range of liver stiffness value ≤ 30%. The cutoff points for TE were established according to the Brazilian Society of Hepatology and Brazilian College of Radiology practice guidance for the use of elastography in liver diseases for HCV patients (7.1 kPa for F2, 9.5 kPa for F3, and 12.5 kPa for F4)[ 14 ]. The controlled attenuation parameter (CAP) was evaluated in all TE in a complementary manner to identify steatosis.…”

Section: Methodsmentioning

confidence: 99%

Relationship between phase angle, steatosis, and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus

Fernandes¹,

Tovo²,

Silva³

et al. 2022

WJH

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BACKGROUND Malnutrition, lipodystrophy, and dyslipidemia are prevalent characteristics in patients with human immunodeficiency virus (HIV) infection with or without previous treatment. Such a clinical condition can lead to the hypothesis of the presence of hepatic steatosis with possible progression to fibrosis and the risk of hepatocellular carcinoma. Notably, a low phase angle (PA), evaluated by bioelectrical impedance analysis (BIA), is an independent prognostic marker of clinical progression and survival in HIV-infected patients. AIM To evaluate the relationship between PA and body composition with steatosis and hepatic fibrosis in HIV/hepatitis C virus (HCV)-coinfected patients. METHODS A retrospective observational study by convenience sampling of coinfected HIV/HCV patients, in which all patients underwent transient elastography (Fibroscan) and BIA evaluation. Student’s t test was used for group comparisons, and Spearman’s or Pearson’s correlation test was used when appropriate. The significance level was set at 5%, and analyses were performed using SPSS version 21.0. RESULTS Forty-three patients who received antiretroviral therapy met the inclusion criteria, and 23 (53.5%) were under treatment with protease inhibitors (PIs). There was no difference in PA between those who used PIs and those who did not ( P = 0.635). There was no correlation between fibrosis grade and PA ( P = 0.355) or lean mass ( P = 0.378). There was a significant inverse correlation between the controlled attenuation parameter (CAP) and lean mass ( P = 0.378), positive correlation between PA and lean mass ( P = 0.378), and negative correlation between PA and fatty mass ( P = 0.378), although the CAP and PA were not correlated. When evaluated by sex, no significant correlations were found. CONCLUSION PA determines the muscle function of HIV/HCV-coinfected patients, and the CAP values reinforce the association with lean mass, suggesting that patients require early nutritional interventions.

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Section: Methodsmentioning

confidence: 99%

Relationship between phase angle, steatosis, and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus

Fernandes¹,

Tovo²,

Silva³

et al. 2022

WJH

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“…A consensus of different societies of radiology and hepatology have been reporting that transient elastography and ARFI-based elastography have similar accuracy to identify liver cirrhosis [7,8]. 2D-SWE implemented in ultrasound systems from different manufacturers has been commercialised and used in clinical practice worldwide.…”

Section: Introductionmentioning

confidence: 99%

Accuracy and concordance of two-dimensional shear-wave elastography using transient elastography as the reference in chronic viral hepatitis and HIV infection in Rio de Janeiro, Brazil

Coelho

Fernandes

Cardoso

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Objectives Evaluate the accuracy and agreement of two-dimensional shear-wave elastography (2D-SWE) LOGIQ-S8 with transient elastography in patients from Rio de Janeiro, Brazil. Method This retrospective study compared liver stiffness measurements (LSMs) using transient elastography (M and XL probes) and 2D-SWE GE-LOGIQ-S8 performed by a single experienced operator on the same day in 348 consecutive individuals with viral hepatitis or HIV infection. Suggestive and highly suggestive compensated-advanced chronic liver disease (c-ACLD) were defined by transient elastography-LSM ≥10 kPa and ≥15 kPa, respectively. Agreement between techniques and accuracy of 2D-SWE using transient elastography-M probe as the reference was assessed. Optimal cut-offs for 2D-SWE were identified using the maximal Youden index. Results Three hundred five patients [61.3% male, median age = 51 [interquartile range (IQR), 42–62] years, 24% with hepatitis C virus (HCV) ± HIV; 17% with hepatitis B virus (HBV) ± HIV; 31% were HIV mono-infected and 28% had HCV ± HIV post-sustained virological response] were included. The overall correlation (Spearman’s ρ) was moderate between 2D-SWE and transient elastography-M (ρ = 0.639) and weak between 2D-SWE and transient elastography-XL (ρ = 0.566). Agreements were strong (ρ > 0.800) in people with HCV or HBV mono-infection, and poor in HIV mono-infected (ρ > 0.400). Accuracy of 2D-SWE for transient elastography-M ≥ 10 kPa [area under the receiver operating characteristic (AUROC) = 0.91 (95% confidence interval [CI], 0.86–0.96); optimal cut-off = 6.4 kPa, sensitivity = 84% (95% CI, 72–92), specificity = 89% (95% CI, 84–92)] and for transient elastography-M ≥ 15 kPa [AUROC = 0.93 (95% CI, 0.88–0.98); optimal cut-off = 7.1 kPa; sensitivity = 91% (95% CI, 75–98), specificity = 89% (95% CI, 85–93)] were excellent. Conclusion 2D-SWE LOGIQ-S8 system had a good agreement with transient elastography and an excellent accuracy to identify individuals at high risk for c-ACLD.

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Effect of fish oil supplementation on the concentration of miRNA-122, FGF-21 and liver fibrosis in patients with NAFLD: Study protocol for a randomized, double-blind and placebo-controlled clinical trial

Barroso,

Salarini,

Leite

et al. 2023

Clinical Nutrition ESPEN

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Brazilian Society of Hepatology and Brazilian College of Radiology practice guidance for the use of elastography in liver diseases

Cited by 4 publications

References 106 publications

Relationship between phase angle, steatosis, and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus

Relationship between phase angle, steatosis, and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus

Accuracy and concordance of two-dimensional shear-wave elastography using transient elastography as the reference in chronic viral hepatitis and HIV infection in Rio de Janeiro, Brazil

Effect of fish oil supplementation on the concentration of miRNA-122, FGF-21 and liver fibrosis in patients with NAFLD: Study protocol for a randomized, double-blind and placebo-controlled clinical trial

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