Brazilin: An updated literature-based review on its promising therapeutic approaches and toxicological studies

Jamaddar, Sarmin; Sarkar, Chandan Kumar; Akter, Shamima; Mubarak, Mohammad S.; El-Nashar, Heba A. S.; El-Shazly, Mohamed; Islam, Muhammad Torequl

doi:10.1016/j.sajb.2023.04.053

Cited by 15 publications

(10 citation statements)

References 94 publications

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“…Nitta and his co-authors isolated potent histidine decarboxylase inhibitors namely, quercetin 3-O-β-D-glucuronide 6''-methyl ester (14) and quercetin 3-O-(2-O-galloyl)glucoside (15) from the ethyl acetate extract of P. racemose berries. [43] Another phytochemical study on the methanol extract revealed isolation of two flavonoid glycosides namely, quercetin 3-O-β-D-glucuronopyranoside (16), and quercitrin (17), coupled with a new dihydrokaempferol namely, 3-carboxy-6,8-di-C-methyl-dihydrokaempferol 3-O-β-D-glucopyranoside (18). [44] Further, six flavonoids were isolated from the 80 % aqueous methanol extract of P. racemosa J.W.…”

Section: Flavonoidsmentioning

confidence: 99%

“…[44] Further, six flavonoids were isolated from the 80 % aqueous methanol extract of P. racemosa J.W. Moore leaves and identified as avicularin (19), quercetin 3-O-β-D-arabinopyranoside (20), quercetin 3-O-β-Dglucopyranoside (16), quercitrin (17), cynaroside (21), and quercetin (22). P. psuedocaryophyllus exhibits strong antioxidant ability due to a content of polyphenols (199.33 � 3.79 mg/g) & flavonoids (28.32 � 1.46 mg/g) such as rutin (23) which can be obtained from the ethanol extract.…”

Section: Flavonoidsmentioning

confidence: 99%

“…In traditional medicine, P. dioica and P. racemosa were reported to be the widely used species. [15][16][17] The fruits and leaves of P. dioica were used for arthrosis, stomachache, toothache, neuralgia, gastrosis, myalgia, flatulence and candidiasis due to its analgesic, carminative, digestive and antimicrobial properties. [18] The Haitaian immigrants and their descendants in the province of Camaguey, Cuba used P. dioica seeds with rum and sugar to treat abdominal pain.…”

Section: Introductionmentioning

confidence: 99%

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Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

El‐Nashar,

Ali,

Salem

2023

Chemistry & Biodiversity

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Pimenta is a genus of flowering plants belonging to family Myrtaceae, native to the West Indies, Mexico, and South America. Numerous traditional uses were reported as anti‐inflammatory, analgesic, antipyretic, antirheumatic, antigout, sedative diuretic, sexual stimulant, arthritis and fatigue. This article aims to clarify the reported data about the genus Pimenta, providing a comprehensive overview of its botany, traditional uses, phytochemical profile, pharmacological activities for future exploration of plant‐based drugs and therapeutic approaches. The data were collected from several databases such as Web of Science, Pubmed and Proquest using the terms: "Pimenta", "Pimenta/ phytochemistry", and "Pimenta extracts/ biological activity".The phytochemicals of Pimenta species include tannins, saponins, flavonoids, phenylpropanoids, monoterpenes, sesquiterpenes and essential oils. Several Pharmacological biological activities have been reported for different species such as antihypertensive, antioxidant, antimicrobial, antiviral, histidine decarboxylase inhibition, hypoglycemic, anticancer, anti‐inflammatory, analgesic, antipyretic, acaricidal, anxiolytic, anti‐depressant and anti‐estrogenic. Several scientific reports have been published on various isolated phytochemicals and pharmacological properties of Pimenta species that confirm its ethnobotanical and traditional history. However, in vivo studies on different extracts and their phytoconstituents, alongside mechanistic analysis deserve more attention in future research to provide better guidance to utilize Pimenta as medicinal resources.

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Section: Flavonoidsmentioning

confidence: 99%

Section: Flavonoidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

El‐Nashar,

Ali,

Salem

2023

Chemistry & Biodiversity

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“…[15,16] The utilization of medicinal plants in healthcare dates back to ancient times, and different studies have been carried out worldwide to validate their efficacy. [17][18][19] These studies have led to the development of plant-based medications. [20][21][22][23] In recent years, the use of phytochemicals derived from dietary components or traditional medicines to combat or prevent human diseases has received considerable public and scientific interest.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Bhuia,

Chowdhury,

Sonia

et al. 2023

Chemistry & Biodiversity

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With the increasing prevalence of cancer and the toxic side effects of synthetic drugs, natural products are being developed as promising therapeutic approaches. Gracillin is a naturally occurring triterpenoid steroidal saponin with several therapeutic activities. It is obtained as a major compound from different Dioscorea species. This review was designated to summarize the research progress on the anti‐cancer activities of gracillin focusing on the underlying cellular and molecular mechanisms, as well as its pharmacokinetic features. The data were collected (up to date as of May 1, 2023) from various reliable and authentic literatures comprising PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings demonstrated that gracillin displays promising anticancer effects through various molecular mechanisms, including anti‐inflammatory effects, apoptotic cell death, induction of oxidative stress, cytotoxicity, induction of genotoxicity, cell cycle arrest, anti‐proliferative effect, autophagy, inhibition of glycolysis, and blocking of cancer cell migration. Additionally, this review highlighted the pharmacokinetic features of gracillin, indicating its lower oral bioavailability. As a conclusion, it can be proposed that gracillin could serve as a hopeful chemotherapeutic agent. However, further extensive clinical research is recommended to establish its safety, efficacy, and therapeutic potential in cancer treatment.

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“…The majority of chemotherapy drugs used to treat PCa over the past four decades are derived from herbs; Moreover, isolated compounds from herbal plants are presently being investigated to provide different lead structures, which can be used as frameworks to make new and more potent anticancer drugs (Abdelghffar et al, 2021; Mann, 2002). These compounds may be able to fight cancer because they act as antioxidants, get rid of free radicals, and stop enzymes in cells from changing DNA (El‐Nashar, Mostafa, Eldahshan, & Singab, 2022; Jamaddar et al, 2023; Rabie et al, 2023). These characteristics are expected to protect against somatic mutations and adverse epigenetic DNA changes when taken together (Reddy et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

Mia,

Dey,

Sakib

et al. 2023

Phytotherapy Research

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Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number of PCa patients continues to rise despite the availability of effective treatments in recent decades. The current therapy with chemotherapeutic drugs has been largely ineffective due to multidrug resistance and the conventional treatment has restricted drug accessibility to malignant tissues, necessitating a higher dosage resulting in increased cytotoxicity. Plant‐derived bioactive compounds have recently attracted a great deal of attention in the field of PCa treatment due to their potent effects on several molecular targets and synergistic effects with anti‐PCa drugs. This review emphasizes the molecular mechanism of phytochemicals on PCa cells, the synergistic effects of compound‐drug interactions, and stem cell targeting for PCa treatment. Some potential compounds, such as curcumin, phenethyl‐isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti‐PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways. In addition, multiple studies have demonstrated that the isolated natural compounds: d‐limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects. Further, a significant number of natural compounds effectively target PCa stem cells. However, further high‐quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa.

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Brazilin: An updated literature-based review on its promising therapeutic approaches and toxicological studies

Cited by 15 publications

References 94 publications

Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

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