BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients

Abstract

The proportion of Korean ovarian cancer patients with a strong family history was significant, and the prevalence of BRCA1 and BRCA2 mutations in such patients was high.

Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer

“…Third, some of our Korean patients did not know the history of their family disease owing to the separation of families during the Korean War, which is the same case as a previous report. 18 Therefore, the real proportion of HNPCC in Korean patients with endometrial cancer may be higher than that of the current study. Despite these limitations, this study establishes for the first time that the BMI of patients with HNPCC related to endometrial cancer was lower than that of the patients with sporadic endometrial cancer in Korea.…”

Germline Mutations of BRCA1 and BRCA2 in Korean Ovarian Cancer Patients

“…The results of our analysis indicate that the 1041_1043delAGCinsT BRCA1 mutation (n = 4; 10.2%), which was repeated twice in the present study, and the 3746insA BRCA1 mutation (n = 4; 10.2%) were considered the most potential founder mutations in KoOC ( Table 5). The latter mutation was reported 3 times in Lim et al 11 and once in Kim et al 13 was not reported in the present study. In addition, the 2552delC (n = 3; 7.7%) and 509C 9 A (n = 3; 7.7%) were also considered a candidate for founder mutation.…”

Survival outcome in endometrial cancer patients according to hereditary predisposition

“…Therefore, it is completely reproducible. This is also one of the strong merits of the study [26]. Third, we did not perform genetic testing to confirm a germline mutation.…”