Tobias and my two paranymphs Frederik and Vincent from Twente-as well as Holger, Andreas, Eika, Patrick, Colin, Constantina, Sebastian, Micha and Catja from Münster. While climbing different stages and enjoying good times together, I am glad that some of you became close friends of mine. Looking forward, several of you already completed their academic journey, while others are still on different heights of their mountains. Good luck to all of you in completing your projects-just keep climbing, I am sure you will make it! Special thanks go to my family-above all my mother Edith and my brother Benedikt. Thank you very much for your patience, understanding and unconditional support in the last years. You helped me keeping my motivation and recharging my batteries when energy was low. I could always count on you. This thesis is dedicated to you. Last but not least, I am very grateful to have my longtime friends Marina, Daniela, Laura, Anne and Vanessa from my hometown Wiedenbrück; the "Stuttgart Crew" Jule, Johanna, Martina, Kathrin, Eva, Bene and Konrad; and my dear friends Tatiana and Josiane in Münster. On my journey towards the top of the mountain, you always kept celebrating small stage victories with me and encouraging me when muscles were aching. All of you have been part of this exciting hike and joined me climbing it to the summit cross. Thanks a lot. Without you, this project would have been impossible.