2020
DOI: 10.1021/acs.jpcb.0c04139
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Breakage of Hydrophobic Contacts Limits the Rate of Passive Lipid Exchange between Membranes

Abstract: The maintenance of heterogeneous lipid compositions among cellular membranes is key to biological function. Yet, even the simplest process that could be responsible for maintaining proper lipid distributions, passive lipid exchange of individual molecules between membranes, has eluded a detailed understanding, due in part to inconsistencies between experimental findings and molecular simulations. We resolve these discrepancies by discovering the reaction coordinate for passive lipid exchange, which enables a c… Show more

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Cited by 19 publications
(66 citation statements)
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“…Specifically, we quantified the barriers for transporting glycerophospholipids, the major structural component of cell membranes (1,2), with a diversity of acyl chains and headgroups. To do so efficiently, we calculated free energy profiles as a function of the reaction coordinate LxS , which we first identified for DMPC transport between L phase membranes (27) and here assumed applicable to similar Manuscript submitted to Biophysical Journal 9 systems. All of the free energy profiles exhibit a rate-limiting barrier at nearly the same value of the reaction coordinate (Fig.…”
Section: Discussionmentioning
confidence: 99%
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“…Specifically, we quantified the barriers for transporting glycerophospholipids, the major structural component of cell membranes (1,2), with a diversity of acyl chains and headgroups. To do so efficiently, we calculated free energy profiles as a function of the reaction coordinate LxS , which we first identified for DMPC transport between L phase membranes (27) and here assumed applicable to similar Manuscript submitted to Biophysical Journal 9 systems. All of the free energy profiles exhibit a rate-limiting barrier at nearly the same value of the reaction coordinate (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…1A). As determined in our previous study (27), the reaction coordinate, LxS (which was labeled in ( 27)), is a linear combination of two order parameters that measure hydrophobic lipid-membrane contacts between the transferring lipid and closest membrane leaflet (Fig. 1B).…”
Section: Free Energy Calculationsmentioning
confidence: 97%
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