Breakdown of classical paradigms in relation to membrane structure and functions

Frías, María de los Ángeles; Disalvo, E.A.

doi:10.1016/j.bbamem.2020.183512

Cited by 8 publications

(15 citation statements)

References 176 publications

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“…In this regard, the thermodynamic response of an interphase (i.e., the change in surface tension) to bioeffectors is related to water organized around the lipids beyond the first hardcore hydration shell. This type of water between lipids beyond the first hydration shell sustains the original model of Defay-Prigogine in which the interphase is a bidimensional solution of hydrated head groups immersed in water [ 28 , 32 ].…”

Section: The Surface Domains: Excluded Volume Conceptmentioning

confidence: 70%

“…The point that the bilayer/monolayer system cannot be appropriately treated with laws defined for bulk macroscopic systems derives from the need to consider new paradigms introducing concepts of surface physical chemistry [ 28 ]. This new view is based on Einstein’s words in the heading of this article.…”

Section: The Membrane Interphase Modelmentioning

confidence: 99%

“…For a given water activity at the membrane, the perturbation (ΔΠ) depends on the type of bioeffector, and of lipids and it may have different consequences. Among them, drastic changes in the dielectric permittivity of the membrane maintaining the bilayer conformation allow permeation of polar and ionic solutes, a process that cannot be explained by the classical non-polar slab of the bilayer in classical models [ 28 , 53 ]. Another consequence is the induction of non bilayered structure abandoning the bilayer conformation [ 54 ].…”

Section: Critical Water Activity and The Cut Off Surface Pressurementioning

confidence: 99%

See 2 more Smart Citations

Water as a Link between Membrane and Colloidal Theories for Cells

Disalvo¹,

Rosa²,

Cejas³

et al. 2022

Molecules

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This review is an attempt to incorporate water as a structural and thermodynamic component of biomembranes. With this purpose, the consideration of the membrane interphase as a bidimensional hydrated polar head group solution, coupled to the hydrocarbon region allows for the reconciliation of two theories on cells in dispute today: one considering the membrane as an essential part in terms of compartmentalization, and another in which lipid membranes are not necessary and cells can be treated as a colloidal system. The criterium followed is to describe the membrane state as an open, non-autonomous and responsive system using the approach of Thermodynamic of Irreversible Processes. The concept of an open/non-autonomous membrane system allows for the visualization of the interrelationship between metabolic events and membrane polymorphic changes. Therefore, the Association Induction Hypothesis (AIH) and lipid properties interplay should consider hydration in terms of free energy modulated by water activity and surface (lateral) pressure. Water in restricted regions at the lipid interphase has thermodynamic properties that explain the role of H-bonding networks in the propagation of events between membrane and cytoplasm that appears to be relevant in the context of crowded systems.

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Section: The Surface Domains: Excluded Volume Conceptmentioning

confidence: 70%

Section: The Membrane Interphase Modelmentioning

confidence: 99%

Section: Critical Water Activity and The Cut Off Surface Pressurementioning

confidence: 99%

See 1 more Smart Citation

Water as a Link between Membrane and Colloidal Theories for Cells

Disalvo¹,

Rosa²,

Cejas³

et al. 2022

Molecules

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show abstract

“…Water can extend into the first 4-5 C atoms below the carbonyl groups and from the plane of the phosphates and the different polar residues attached to it, toward the external water. Consequently, the neat differentiation of water near the groups and the bulk as described by the definition of the surface potentials is gradually diluted [1,45].…”

Section: Zeta Potential and Dipole Potential Correlationmentioning

confidence: 99%

“…The hydration of the lipids is determinant for the thermodynamic stability and structural dynamics and are a clue to understand the response of the membrane to environmental changes and biologically relevant bio-effectors (hydric and oxidative stress, hydrolytic enzymes, signal peptides, antioxidants). A recent model of lipid membranes includes explicitly the lipid-water interaction considering the membrane as composed by a bidimensional solution of hydrated polar head groups of phosphatidylcholines, named the interphase [1][2][3][4][5][6][7] (Figure 1). This model can be sustained in terms of the formalism of Thermodynamics of Irreversible Processes, in which the membrane is considered as an open system with respect to water exchange.…”

Section: Introductionmentioning

confidence: 99%

Surface Characterization of Lipid Biomimetic Systems

Disalvo

Frías

2021

Membranes

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Zeta potential and dipole potential measures are direct operational methodologies to determine the adsorption, insertion and penetration of ions, amphipathic and neutral compounds into the membranes of cells and model systems. From these results, the contribution of charged and dipole groups can be deduced. However, although each method may give apparent affinity or binding constants, care should be taken to interpret them in terms of physical meaning because they are not independent properties. On the base of a recent model in which the lipid bilayer is considered as composed by two interphase regions at each side of the hydrocarbon core, this review describes how dipole potential and zeta potential are correlated due to water reorganization. From this analysis, considering that in a cell the interphase region the membrane extends to the cell interior or overlaps with the interphase region of another supramolecular structure, the correlation of dipole and electrostatic forces can be taken as responsible of the propagation of perturbations between membrane and cytoplasm and vice versa. Thus, this picture gives the membrane a responsive character in addition to that of a selective permeability barrier when integrated to a complex system.

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Lipids, membranes, colloids and cells: A long view

Bagatolli

Stock²

2021

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Breakdown of classical paradigms in relation to membrane structure and functions

Cited by 8 publications

References 176 publications

Water as a Link between Membrane and Colloidal Theories for Cells

Water as a Link between Membrane and Colloidal Theories for Cells

Surface Characterization of Lipid Biomimetic Systems

Lipids, membranes, colloids and cells: A long view

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