2023
DOI: 10.3389/fbioe.2023.1176557
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Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Abstract: Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is to provide high precision and accuracy while using minimal reagents and equipment. The benefits of this approach include greater control over experimental conditions, faster analysis, and improved experimental reproducibility. Microfluidic devices, also known … Show more

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Cited by 15 publications
(5 citation statements)
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References 222 publications
(273 reference statements)
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“…Instead, it employs injection molding and thermal bonding techniques with polystyrene (PS), similar to commercial cell culture labware, to reduce biocompatibility risks 17 . PS, known for its glass like optical properties 18 , is ideal for high-content imaging and serves as a high moisture barrier while being non-absorptive for small hydrophilic and hydrophobic molecules. While other thermoplastics like COP and COC are used in OOC technology 19 , PS is preferred for its lower cost and lower glass transitioning temperature, enabling faster turnaround time during thermal bonding.…”
Section: Discussionmentioning
confidence: 99%
“…Instead, it employs injection molding and thermal bonding techniques with polystyrene (PS), similar to commercial cell culture labware, to reduce biocompatibility risks 17 . PS, known for its glass like optical properties 18 , is ideal for high-content imaging and serves as a high moisture barrier while being non-absorptive for small hydrophilic and hydrophobic molecules. While other thermoplastics like COP and COC are used in OOC technology 19 , PS is preferred for its lower cost and lower glass transitioning temperature, enabling faster turnaround time during thermal bonding.…”
Section: Discussionmentioning
confidence: 99%
“…38 World-wide, the majority of higher education institutions still do not have these types of facilities. 39,40 That lack of resources not only directly limits access to effective miniaturization science education, 20 it stands in direct opposition to needs in low resource settings that microsystems could address if there was greater awareness and functional knowledge ( e.g. , creating new, low-cost, shelf stable, point-of-care diagnostics).…”
Section: Learning Activitymentioning
confidence: 99%
“…For instance, 3D printing allows for the rapid prototyping of complex microfluidic structures with high precision . For a more comprehensive understanding of the cutting-edge technologies employed in the fabrication of microfluidic devices, there is recent literature that provides detailed analysis and insights into these advancements. …”
Section: Microfluidic Devicesmentioning
confidence: 99%