Breaking the symmetry: C₁-salans with (N–H) backbones

Abstract

We disclose a synthetic route that providess an unprecedented library of C1 salan ligands endowed with (N-H) backbones, previously limited to N-methylated backbones. Efforts to identify a generic complexation protocol...

Chemical Chartographisis: a contemporary perspective in molecular design and synthesis

“…From the coordination chemistry perspective, we established a convenient route to access asymmetric salan and salen frameworks in bulk. 50 This route yielded several tetradentate asymmetric Cu II salen/salan complexes, which were found to promote the A 3 coupling reaction at the same rate and suggested mere electronic and/or steric effect(s) accounted for the rate. We concluded that using tetradentate salen frameworks is the limiting factor to improving catalytic efficacy, possibly because the ligand saturates the coordination sphere of the metal centre, and we hypothesised that a Cu II complex built from a tridentate ligand and weakly coordinating anion would be an ideal component to overcome this obstacle and increase the reaction rate.…”

“…From the coordination chemistry perspective, we established a convenient route to access asymmetric salan and salen frameworks in bulk. 50 This route yielded several tetradentate asymmetric Cu II salen/salan complexes, which were 2 for more info).…”

“…The salan frame has been decorated with carbohydrate 66 or sulfonate groups, 67 but these frameworks are expected to result in poor Blood Brain Barrier permeability. From the functionality comparison of the previous known dynamic systems and our expertise in accessing asymmetric salan frameworks in bulk, 50 we rationally designed a highly modifiable tetradentate N 3 O copper chelating scaffold, Salpyran . This exhibits selectivity comparable to the state-of-the-art components with Cu II selectivity over Zn II (Fig.…”

“…From the coordination chemistry perspective, we established a convenient route to access asymmetric salan and salen frameworks in bulk. 50 This route yielded several tetradentate asymmetric Cu II salen/salan complexes, which were 2 for more info). found to promote the A 3 coupling reaction at the same rate and suggested mere electronic and/or steric effect(s) accounted for the rate.…”

Fluorine-based Zn salan complexes

“…[57][58][59][60][61][62][63][64] These compounds are susceptible to oxidative dehydrogenation, depending on the solvent medium. 65,66 Only 31 crystal structures have been deposited in the CSD. 67 The sp 3 carbon atoms of the salan framework impose flexibility and, consequently, possible alterations in the geometry of the metal centre, deviating from the dominant square planar and/or square pyramidal conformation.…”