Breaking the time and space limitation of point-of-care testing strategies: Photothermometric sensors based on different photothermal agents and materials

Wei, Mingming; Rao, Honghong; Niu, Zhengrong; Xue, Xin; Luo, Mingyue; Zhang, Mengjie; Huang, Huiyi; Zhang, Xue; Lu, Xiaoquan

doi:10.1016/j.ccr.2021.214149

Cited by 60 publications

(29 citation statements)

References 296 publications

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“…The analytes recognition process involves several possible mechanisms: the analyte metabolization through the enzyme and the chemical concentration are evaluated by estimating the catalyst effect on the former through the latter. The enzyme is restrained or enhanced by the catalyst, so that the measured concentration is related to the diminished enzymatic arrangement, and the changes in enzymatic properties [47,48]. Because of the lengthy research on this kind of sensors, different BS based on enzymatic specificity can be produced.…”

Section: Bs Categories Bs Based On Lightmentioning

confidence: 99%

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The Role of Nanomaterials in the Recent Development of Electrochemical Biosensors

Abdulhussein¹,

Al-Kazazz²,

Rheima³

2023

Port. Electrochim. Acta

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Medical forensics and homeland security have been focusing on the food and beverage industries, for water quality remote sensing, drug residue determination in food, etc. NT is playing a growing role in BS development. NT-based BS, also known as NBS technology, are reshaping the medical field. They are used in metabolite measurement, diabetes monitoring, and other applications, such as environmental protection. Pesticide and heavy metal ions detection in river water, as well as genomes sequencing the use of NM in BS design have increased their sensitivity and ability to also develop NP special properties, such as high electrical conductivity, improved shock resistance, sensitive response and flexibility. These advances result from the confluence of NP characteristics, allowing for the presentation of numerous modern flag transduction innovations in BS, such as the development of devices, and forms for manufacturing them and enhancing their measurement capability. Imaging the nanoscale objects has improved sensors connected with tiny atoms. Many mechanical devices, optical resonators and bi-functional architecture based on NBS have been developed. BS have also been discussed in this research, in order to highlight their critical applications in a variety of fields. This study discusses the various types of BS that depend on multiple types of NM, as well as their biological and implicational factors and analytical techniques, such as amperometric, CV potentiometric optical techniques, and other measurements methods that use enzyme and non-enzymatic BS.

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Section: Bs Categories Bs Based On Lightmentioning

confidence: 99%

“…Because of the lengthy research on this kind of sensors, different BS based on enzymatic specificity can be produced. Due to the enzymatic structure susceptibility, improving its sensitivity, stability and adaptability is costly and complicated [48]. Electrochemical transducers are the most common type used in EBS.…”

Section: Bs Categories Bs Based On Lightmentioning

confidence: 99%

The Role of Nanomaterials in the Recent Development of Electrochemical Biosensors

Abdulhussein¹,

Al-Kazazz²,

Rheima³

2023

Port. Electrochim. Acta

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“…Organic polymers are a type of special materials that can be generated by the oxidizing polymerization of small molecule monomers. Because they often have the unique merits of excellent biocompatibility, high photostability, and strong light absorption capability, and because their photophysical properties are mainly determined by the chemical structure of their precursors, organic polymers are well suitable for different sensing applications such as fluorescent sensing, photothermal sensing, and so forth. − Nevertheless, except for polydopamine nanoparticles, no other organic polymers have been reported to have fluorescence–photothermal dual features till now. Thereby, it is quite necessary to search for more new organic polymers with superior fluorescence and photothermal dual features.…”

Section: Introductionmentioning

confidence: 99%

In Situ Formation of o-Phenylenediamine Cascade Polymers Mediated by Metal–Organic Framework Nanozymes for Fluorescent and Photothermal Dual-Mode Assay of Acetylcholinesterase Activity

Wei

et al. 2022

Anal. Chem.

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A fluorescent and photothermal dual-mode assay method was established for the detection of acetylcholinesterase (AChE) activity based on in situ formation of o-phenylenediamine (oPD) cascade polymers. First, copper metal−organic frameworks of benzenetricarboxylic acid (Cu-BTC) were screened out as nanozymes with excellent oxidase-like activity and confinement catalysis effect. Then, an ingenious oPD cascade polymerization strategy was proposed. That is, oPD was oxidized by Cu-BTC to oPD oligomers with strong yellow fluorescence, and oPD oligomers were further catalyzed to generate J-aggregation, which promotes the formation of oPD polymer nanoparticles with a high photothermal effect. By utilizing thiocholine (enzymolysis product of acetylthiocholine) to inhibit the Cu-BTC catalytic effect, AChE activity was detected through the fluorescence−photothermal dual-signal change of oPD oligomers and polymer nanoparticles. Both assay modes have low detection limitation (0.03 U L −1 for fluorescence and 0.05 U L −1 for photothermal) and can accurately detect the AChE activity of human serum (recovery 85.0−111.3%). The detection results of real serum samples by fluorescent and photothermal dual modes are consistent with each other (relative error ≤ 5.2%). It is worth emphasizing that this is the first time to report the high photothermal effect of oPD polymers and the fluorescence−photothermal dual-mode assay of enzyme activity.

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“…Therefore, it is urgent to establish proven and effective platforms for immunoassays, since the currently available platforms are designed for traditional immunoassays, which are still limited by the high cost and low automation. Thus, how to enable point-of-care (POC) immunoassays for miniaturization of experimental instruments, simplification of operation methods, and instantaneous reporting of results was urgently required [ [30] , [31] , [32] ]. Particularly, the microfluidic chips provide more possibilities for POCTs [ 18 , [33] , [34] , [35] ].…”

Section: Introductionmentioning

confidence: 99%

Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19

Yuan¹,

Chen²,

Wan³

et al. 2022

TrAC Trends in Analytical Chemistry

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Breaking the time and space limitation of point-of-care testing strategies: Photothermometric sensors based on different photothermal agents and materials

Cited by 60 publications

References 296 publications

The Role of Nanomaterials in the Recent Development of Electrochemical Biosensors

The Role of Nanomaterials in the Recent Development of Electrochemical Biosensors

In Situ Formation of o-Phenylenediamine Cascade Polymers Mediated by Metal–Organic Framework Nanozymes for Fluorescent and Photothermal Dual-Mode Assay of Acetylcholinesterase Activity

Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19

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