Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress

Wu, Hao; Wang, Ying; Zhang, Yupeng; Xu, Feng; Chen, Jiepeng; Duan, Lili; Zhang, Tingting; Wang, Jian; Zhang, Fengjiao

doi:10.1016/j.redox.2020.101500

Cited by 130 publications

(91 citation statements)

References 60 publications

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“…Violi et al have shown that NADPH oxidase-2 (NOX-2) is overexpressed in hospitalized COVID-19 patients, causing increased oxidative stress [ 25 ]. In agreement with these results, other authors have shown in macrophages that NOX-2 blockade improves the disease phenotypes thanks to a decrease in oxidative stress [ 26 ]. Interestingly, it is noteworthy that when stimulated by proinflammatory cytokines and other agonists, endothelial cells can mobilize NOX proteins [ 27 ], contributing to local oxidative stress, which in turn produces endothelial dysfunction [ 28 ].…”

Section: Molecular Pathogenesis Of Covid-19supporting

confidence: 88%

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

et al. 2020

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Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak emerged, countless efforts are being made worldwide to understand the molecular mechanisms underlying the coronavirus disease 2019 (COVID-19) in an attempt to identify the specific clinical characteristics of critically ill COVID-19 patients involved in its pathogenesis and provide therapeutic alternatives to minimize COVID-19 severity. Recently, COVID-19 has been closely related to sepsis, which suggests that most deceases in intensive care units (ICU) may be a direct consequence of SARS-CoV-2 infection-induced sepsis. Understanding oxidative stress and the molecular inflammation mechanisms contributing to COVID-19 progression to severe phenotypes such as sepsis is a current clinical need in the effort to improve therapies in SARS-CoV-2 infected patients. This article aims to review the molecular pathogenesis of SARS-CoV-2 and its relationship with oxidative stress and inflammation, which can contribute to sepsis progression. We also provide an overview of potential antioxidant therapies and active clinical trials that might prevent disease progression or reduce its severity.

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Section: Molecular Pathogenesis Of Covid-19supporting

confidence: 88%

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

et al. 2020

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“…Inflammation, infection, and other factors lead to excessive activation of blood coagulation. 16 In this study, the D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than in the survival group, and the differences were statistically significant. The blood of the patients with COVID19 appeared to be in a hypercoagulable state, which resulted in the consumption of coagulation factors, and likely promoted the development of disseminated intravascular coagulation (DIC), resulting in the COVID19 endpoint events.…”

Section: Discussionmentioning

confidence: 45%

Evaluation of organ function in patients with severe COVID-19 infections

Zhu

et al. 2020

Medicina Clínica

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…(3) Moreover, extensive researches have found that coagulation is related to in ammatory response, and IgAN is also an in ammatory disease. IgAN patients are commonly associated with alteration of various in ammatory cytokines [50], which may be related to the activation of procoagulant factors and renal brosis [51,52]. In addition, there are some limitations to our study.…”

Section: Discussionmentioning

confidence: 93%

Coagulation parameters are associated with the prognosis of immunoglobulin A nephropathy: a retrospective study

Xia

Liu

Peng

et al. 2020

Preprint

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Background. Interstitial fibrosis/tubular atrophy (T) score is a known determinant of the progression of immunoglobulin A nephropathy (IgAN). Strong evidence indicates that the components of the coagulation system closely linked with fibrotic events have been highlighted in the kidney. However, whether the coagulation system can affect the renal outcome of IgAN remains unclear. Herein, we investigated the association of coagulation parameters and pathological phenotype of IgAN and their combined effects on the deterioration of renal function.Methods. This retrospective study included N=291 patients with biopsy-proven IgAN from May 2009 to April 2013 in the Second Xiangya Hospital. Clinical data, pathological features were collected, and the associations of coagulation parameters at biopsy, T score, and renal outcome were evaluated. T score indicated the degree of tubular atrophy or interstitial fibrosis. The renal outcome was defined as an end-stage renal disease (ESRD) or an irreversible 50% estimated glomerular filtration rate (eGFR) reduction. Results. Shorter prothrombin time (PT) and the activated partial thromboplastin time (APTT) were significantly associated with T (both p<0.001). PT (<11.15s) or APTT (<29.65s) had worse cumulative survival rate (p=0.008, p=0.027 respectively) and were significantly but not independently associated with a higher risk of renal outcome (p=0.012, p=0.032 respectively). In the combined analyses of PT, APTT, and T lesions, the odd ratios for the outcome were significantly higher in the presence of T with PT (<11.15s) or APTT (<29.65s).Conclusion. Shorter PT and APTT are associated with an increased incidence of the T lesion and are additional factors that portend a poorer prognosis in IgAN. Monitoring coagulation function might be important when assessing the risk of progression. Additional studies exploring the molecular mechanism between coagulation and IgAN pathology are needed.

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Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress

Cited by 130 publications

References 60 publications

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

Evaluation of organ function in patients with severe COVID-19 infections

Coagulation parameters are associated with the prognosis of immunoglobulin A nephropathy: a retrospective study

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