Breaking up sitting time after stroke (BUST-stroke)

English, Coralie; Janssen, Heidi; Crowfoot, Gary; Callister, Robin; Dunn, Ashlee; Mackie, Paul; Oldmeadow, Christopher; Ong, Lin Kooi; Palazzi, Kerrin; Patterson, Amanda; Spratt, Neil J; Walker, Frederick R.; Bernhardt, Julie; Dunstan, David W.

doi:10.1177/1747493018801222

Cited by 17 publications

(22 citation statements)

References 45 publications

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“…A total of 29 trials (33 articles) were identified in our search as meeting all inclusion criteria (Fig 1). One (two articles [20, 30]) additional trial was included on the 13 th June 2018. Therefore, a total of 30 trials (35 articles) were included in this review, of which 53% were not registered with a trial registry.…”

Section: Resultsmentioning

confidence: 99%

“…All trials used a randomised crossover design, expect for one which used a balanced crossover design [31]. In 20 trials, interventions occurred in a laboratory or research facility where participants were supervised during each condition [12, 14, 16, 18, 20, 30, 32–50]. One trial was completed under supervised conditions in an office setting [51] and nine trials were conducted in a laboratory or research facility [19, 31, 52–58] where participants where not reported to be observed during conditions.…”

Section: Resultsmentioning

confidence: 99%

“…Three trials [18, 34, 58] recruited postmenopausal women (aged > 65 years) (Table 2) who were normal weight [58] or overweight [18, 34]. Only one trial presented data for stroke survivors who were 0.25 to 10 years post-stroke, older adults (68 ± 2 years) and overweight [20, 30].…”

Section: Resultsmentioning

confidence: 99%

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What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review

et al. 2019

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The objective of this review was to ascertain the scope of the available literature on the effects of interrupting prolonged sitting time with frequent bouts of physical activity or standing on stroke and recurrent stroke risk factors. Databases Medline, Embase, AMED, CINAHL and Cochrane library were comprehensively searched from inception until 21 st February 2018. Experimental trials which interrupted sitting time with frequent bouts of physical activity or standing in adults (≥ 18 years) were included. Comparison to a bout of prolonged sitting and a measure of at least one first or recurrent stroke risk factor was required to be included. Overall, 30 trials (35 articles) were identified to meet the inclusion criteria. Fifteen trials were completed in participants at an increased risk of having a first stroke and one trial in participants at risk of a recurrent stroke. Outcomes of hypertension and dysglycemia were found to be more favourable following predominately light- to moderate-intensity bouts of physical activity or standing compared to sitting in the majority of trials in participants at risk of having a first stroke. In the one trial of stroke survivors, only outcomes of hypertension were significantly improved. These findings are of significant importance taking into consideration hypertension is the leading risk factor for first and recurrent stroke. However, trials primarily focused on measuring outcomes of dysglycemia and without assessing a dose-response effect. Additional research is required on the dose-response effect of interrupting sitting with frequent bouts of physical activity or standing on first and recurrent stroke risk factors, in those high risk population groups.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review

et al. 2019

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“…To reduce dietary-induced variations in glucose and insulin, dietary intake will be standardised 24 h prior to, and during, each experimental condition based on the procedures employed in our previous trial [ 9 , 10 ]. Participants will follow a dietitian prescribed meal plan and be provided with a standardised pre-experimental day evening meal and asked to abstain from alcohol, caffeine and moderate-to-vigorous physical activity for 48 h before the experimental conditions.…”

Section: Methodsmentioning

confidence: 99%

“…While demonstrating proof of concept, the schedule of activity breaks (3 min every 30 min) is not clinically applicable in every-day life. Therefore, this new study builds on our previous BUST-Stroke trial [ 9 , 10 ] and aims to investigate the dose-response of STAND-EX bouts to reduce recurrent stroke risk and improve cardiometabolic health in stroke survivors.…”

Section: Introduction and Rationalementioning

confidence: 99%

Breaking up sitting time after stroke – How much less sitting is needed to improve blood pressure after stroke (BUST-BP-Dose): Protocol for a dose-finding study

Mackie

Crowfoot

Janssen

et al. 2019

Contemporary Clinical Trials Communications

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Excessive sitting is detrimentally associated with cardiovascular disease and all-cause mortality. Frequent breaks in prolonged sitting can improve cardiometabolic responses in non-stroke populations. However, this has not been established in stroke survivors. This study will determine the most effective dose of activity breaks that (i) produce clinically meaningful improvements in mean systolic blood pressure (primary outcome), postprandial glucose, and insulin responses (secondary outcomes), and (ii) is safe and feasible. We hypothesis that systolic blood pressure, postprandial insulin, and glucose responses will improve with increasing doses of activity and be most effective at the maximum safe and feasible dose of activity. Thirty participants in the most effective dose will provide 80% power to detect a within-person, between-condition, difference of 3.5 mmHg in systolic blood pressure assuming a SD of 15 mmHg, within-person correlation of 0.9, and α = 0.05. Stroke survivors will complete 3 experimental conditions in a within-participant, dose escalation design including (i) uninterrupted sitting (8 h), (ii) Dose 1: uninterrupted sitting with bouts of light-intensity exercises while standing (initial dose involves two 5-min breaks), and (iii) Dose 2: two additional 5-min breaks above Dose 1. Ambulatory blood pressure will be collected every 30 min during experimental conditions and hourly for 24-h post-experimental conditions. Blood samples will be collected every 30 min during 2-h postprandial periods. This study will identify the most effective dose of light-intensity exercises while standing to improve cardiometabolic responses in stroke survivors.

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Interventions for reducing sedentary behaviour in people with stroke

Saunders

Mead

Fitzsimons

et al. 2021

Cochrane Database of Systematic Reviews

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This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To determine whether interventions primarily intended to reduce time spent in sedentary behaviour after stroke reduce sedentary time, and whether they modify cardiovascular risk, and reduce the risk of death or secondary vascular events. We will also include interventions intended to reduce the length of prolonged uninterrupted periods of sedentary behaviour (i.e. interventions to fragment or interrupt).

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Breaking up sitting time after stroke (BUST-stroke)

Abstract: Frequent, short bouts of light-intensity physical activity did not have a significant effect on post-prandial plasma glucose and insulin in this sample of people with stroke. Further studies are needed to identify strategies that improve inactivity-related glucose metabolism after stroke.

Cited by 17 publications

References 45 publications

What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review

What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review

Breaking up sitting time after stroke – How much less sitting is needed to improve blood pressure after stroke (BUST-BP-Dose): Protocol for a dose-finding study

Interventions for reducing sedentary behaviour in people with stroke

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