Breakthrough COVID-19 infection inducing acute epiglottitis in an immunized host

Mitchell, Matthew; Buras, Madison; Shutter, Mollie; Wieters, J. Scott

doi:10.1080/08998280.2022.2079343

Cited by 2 publications

(5 citation statements)

References 10 publications

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“…Every patient received antibiotic treatment. Antibiotics administered to these patients included ceftriaxone [ 15 , 16 , 18 , 22 ], ampicillin–sulbactam [ 13 , 19 , 21 ], clindamycin [ 16 , 20 ], azithromycin [ 13 , 16 ], benzylpenicillin [ 15 ], cefuroxime [ 17 ], metronidazole [ 17 ], moxifloxacin [ 12 ], and amoxicillin [ 22 ]. Additionally, the type of antibiotic administered in one case was not detailed in the literature [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Steroids were administered to 9 of the 11 patients. Dexamethasone [ 15 , 16 , 18 , 19 , 21 , 22 ], hydrocortisone [ 15 , 23 ], methylprednisolone [ 12 ], and prednisone [ 22 ] were administered to these patients.…”

Section: Resultsmentioning

confidence: 99%

“…The vaccination history of these patients, which includes previous Hib vaccination and COVID-19 vaccination during the pandemic, may affect the occurrence and development of COVID-19-related AE. Of 11 patients included, only 3 had a known vaccination status, with 2 having a previous Hib vaccination history and 1 having received the COVID-19 mRNA vaccine [ 19 , 20 , 22 ]. Furthermore, the ethnic background of many patients was not specified.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the four recently reported cases of COVID-19-related AE were treated conservatively with medications without airway intervention [12,[21][22][23]. This treatment success might be due to the prevalence of Omicron variant, which is significantly less virulent than the original strains and pre-Omicron variants [39].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with COVID-19-related AE originated from five countries. The United States contributed the most patients to this systematic review, with six patients accounting for more than half of the total number of patients included in this analysis [13,16,[18][19][20]22]. In second place was Japan, with two patients [21,23].…”

Section: Countries Of Patient Originmentioning

confidence: 99%

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Acute epiglottitis caused by COVID-19: A systematic review

Meng¹,

Han²,

Wang³

2023

Biomol Biomed

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The COVID-19 pandemic has caused substantial population infections worldwide. COVID-19 has been reported to cause acute epiglottitis (AE); nonetheless, COVID-19-related AE is poorly understood by healthcare workers because of the disease’s low occurrence. This systematic review aimed to improve knowledge of the clinical characteristics of COVID-19-related AE. We conducted a comprehensive search of the literature databases PubMed, Web of Science, Embase, and Scopus, using various keywords and descriptors such as "COVID-19," "SARS-CoV-2," and "AE" in combination with the AND/OR operator. This review included 11 patients with COVID-19-related AE, all of whom were adults except for one 15-year-old girl. COVID-19-related AE was more prevalent in males, who accounted for 81.8% of patients. Patients with COVID-19-related AE experienced symptoms such as hoarseness, dysphagia, odynophagia, sore throat, and dyspnea. Hoarseness may be one of the typical symptoms of COVID-19-related AE. Five patients with COVID-19-related AE had coexisting diseases, including hypertension, obesity, diabetes, obstructive sleep apnea, Wolff-Parkinson-White syndrome, and intracranial tumors. Antibiotics and steroids were commonly administered. Five patients with COVID-19-related AE underwent intubation and cricothyroidotomy airway management. Due to the low success rate of intubation, emergency tracheotomy is the recommended option for patients with COVID-19-related AE who present with more severe dyspnea. AE could be an uncommon manifestation of COVID-19, and SARS-CoV-2 infection should be considered as a possible cause of AE. Healthcare workers should be vigilant in recognizing COVID-19-related AE.

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