A NASA-funded research effort has been underway at the Lockheed Martin Advanced Technology Center in Palo Alto and at California State University in Long Beach to develop and test a recently published theory that Newton's equation of motion can be derived from Maxwell's equations of electrodynamics as applied to the zero-point field (ZPF) of the quantum vacuum. In this ZPF-inertia theory, mass is postulated to be not an intrinsic property of matter but rather a kind of electromagnetic drag force (which temporarily is a place holder for a more general vacuum quantum fields reaction effect) that proves to be acceleration dependent by virtue of the spectral characteristics of the ZPF. The theory proposes that interactions between the ZPF and matter take place at the level of quarks and electrons, hence would account for the mass of a composite neutral particle such as the neutron. An effort to generalize the exploratory study of Haisch, Rueda and Puthoff (1994) into a proper relativistic formulation has been successful. Moreover the principle of equivalence implies that in this view gravitation would also be an effect originated in the quantum vacuum along the lines proposed by Sakharov (1968). With regard to exotic propulsion we can definitively rule out one speculatively hypothesized mechanism: matter possessing negative inertial mass, a concept originated by Bondi (1957) is shown to be logically impossible. On the other hand, the linked ZPF-inertia and ZPFgravity concepts open the conceptual possibility of manipulation of inertia and gravitation, since both are postulated to be vacuum phenomena. It is hoped that this will someday translate into actual technological potential, especially with respect to spacecraft propulsion and future interstellar travel capability. A key question is whether the proposed ZPF-matter interactions generating the phenomenon of mass might involve one or more resonances. This is presently under investigation.