Breakthroughs in Melanoma Research

Tanaka, Yohei

doi:10.5772/795

Cited by 9 publications

(1 citation statement)

References 1,469 publications

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“…Большой интерес представляет обзор F. Bocci et al, в котором ЭМП и генерация циркулирующих стволовых клеток (ЦОК) постулируются как фундаментальные причины, способствующие образованию метастазов и рецидиву опухоли [42]. ЭМП часто играет решающую роль в регуляции эпигенетических процессов, морфофункциональных свойствах клеток при прогрессировании опухоли и формировании метастазов.…”

Section: возможное участие рта в запуске прогрессии клеток меланомыunclassified

Analysis of Cancer-Testis Antigens as Potential Markers for Dissemination of Primary Human Skin Melanoma

et al. 2021

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Purpose of the study: to analyze characteristics of cancer-testis antigens (Ctas) as potential biomarkers for dissemination of primary human skin melanoma (sm).Material and Methods. Recent publications from Pubmed, scopus and elibrary databases were analyzed for the available appropriate literature review. In total, 176 papers reported the description of Ctas and encoding genes and their potential for prognosis of primary sm dissemination. The authors included 52 of them in the given review.Results. Two sections of the paper comprise clinically significant characteristics of Ctas and their genes, including overexpression, which is selective for the heterogeneous tumor cell populations and mediated by humoral and/or cellular immune reactions; the association of tumor process and activation of Cta genes by demethylation of promotor sites, which is correlated with tumor progression; and the conditions required for effective immunotherapy involving Ctas and/or their genes.Conclusion. At present, there are no standards or clinical recommendations for the Cta-based prognosis of the early dissemination of primary skin melanoma. Therefore, it is important to study and analyze the Cta and encoding gene characteristics that reveal the connection between primary sm progression and tumor genesis including the role of circulating tumor cells (ctc), similar to stem cells, which have epithelial-mesenchymal transition (emt) phenotype, for clinical diagnostics of early sm dissemination. As a result of the study, the following Ctas could be considered as significant biomarkers of the early sm dissemination: mage-a1, mage-a4 and ny-eso-1, which expression correlates with the clinical pathological description of the disease progression, as well as with the relapse-free period and overall survival of the patients; magea3, which expression correlates with spag5 activation and Cd8+ t-cell abundance; ssx, a marker for stem cell migration including identification of the cells with emt and/or ctcs; and prame, signaling marker for dissemination of the uveal melanoma.

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Section: возможное участие рта в запуске прогрессии клеток меланомыunclassified

Analysis of Cancer-Testis Antigens as Potential Markers for Dissemination of Primary Human Skin Melanoma

et al. 2021

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Nonsurgical facial tightening after a fractional noninsulated microneedling radiofrequency treatment in Asians

Tanaka

2020

Dermatological Reviews

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Background: As our previous three-dimensional (3D) volumetric investigations have shown, noninsulated microneedle radiofrequency (NIMNRF) with 2.5-mm penetration depth needles can induce long-lasting tightening effects. However, further tightening effects for deeper tissues were sometimes required. The objective of this study was to investigate the efficacy of a novel fractional NIMNRF treatment strategy with 5.0-mm penetration depth needles.Materials and Methods: Twenty Asian patients underwent full facial skin tightening using a sharply tapered NIMNRF applicator with a novel fractionated pulse mode.Patients received from 500 to 1000 pulses of 80 to 110 ms duration at a power of 10 to 14 W and a 1.5-to 5.0-mm penetration depth. A topical anesthetic cream was

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