Breakthroughs in the Management of Hepatocellular Carcinoma: Celebrating 50 Years of the Liver Cancer Study Group of Japan

Kudo, Masatoshi

doi:10.1159/000368140

Cited by 3 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer and has the third highest cancer-related death rate 1,2 . While preferable diagnostic criteria and improved therapy have been applied in recent years, the current standard treatments, such as surgical resection and liver transplantation, cannot produce satisfactory results for patients with advanced stages of HCC [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway

Wang

et al. 2021

Cell Death Dis

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is a common high-mortality cancer, mainly due to diagnostic difficulties during its early clinical stages. In this study, we aimed to identify genes that are important for HCC diagnosis and treatment, and we investigated the underlying mechanism of prognostic differences. Differentially expressed genes (DEGs) were identified by using the limma package, and receiver operating characteristic curve analysis was performed to identify diagnostic markers for HCC. Bioinformatics and clinical specimens were used to assess epithelial cell transforming 2 (ECT2) in terms of expression, prognostic value, pathways, and immune correlations. In vitro experiments were used to investigate the underlying mechanism and function of ECT2, and the results were confirmed through in vivo experiments. The integrated analysis revealed 53 upregulated DEGs, and one candidate biomarker for diagnosis (ECT2) was detected. High expression of ECT2 was found to be an independent prognostic risk factor for HCC. ECT2 expression showed a strong correlation with tumor-associated macrophages. We found that ECT2 overexpression increased the migration and proliferation of HCC cells. It also promoted the expression of PLK1, which subsequently interacted with PTEN and interfered with its nuclear translocation, ultimately enhancing aerobic glycolysis and promoting M2 macrophage polarization. M2 macrophages suppress the functions of NK cells and T cells, and this was confirmed in the in vivo experiments. Overall, ECT2 may promote the polarization of M2 macrophages by enhancing aerobic glycolysis and suppressing the functions of immune cells. ECT2 could serve as a candidate diagnostic and prognostic biomarker for HCC.

show abstract

Section: Introductionmentioning

confidence: 99%

ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway

Wang

et al. 2021

Cell Death Dis

View full text Add to dashboard Cite

show abstract

“…After a mean follows up of 32 months, disease-free survival and overall survival were 40.2 and 23.3 months for the laparoscopic group, and 47.7 and 31.4 months for OR group (PNS) [5]. In other studies looking specifically at LLS, the vast majority of these aforementioned clinical benefits were replicated [1,2,4,[6][7][8][9][10][11][12]. Figueredo and Yeung concluded that LLR reduced pain, inpatient days with more or less comparable operative outcome.…”

Section: Discussionmentioning

confidence: 95%

“…The first liver resection was reported by Dr. Ichio Honjo of (Kyoto University in 1949, and Dr. Jean-Louis Lortat-Jacob of France in 1952 [1,2]. The first laparoscopic nonanatomic resection of a Focal Nodular Hyperplasia (FNH) was reported by Gagner and colleagues in 1992, and this was followed by the first report of laparoscopic anatomic liver resection in 1996 [3].…”

Section: Introductionmentioning

confidence: 99%

Cost and Clinical Efficacy of Laparoscopic vs. Open Approach in Liver Resection

Sharma¹,

Liang²,

Xiao³

et al. 2018

Surgery Curr Res

View full text Add to dashboard Cite

Background: Hesitation but gradual recognition of laparoscopic liver resection has been gaining popularity in developed countries among the specialized hospitals. On contrary, there has always been a debate about high cost and complexity of laparoscopic as compared to open liver resection resulting in the delayed adoption of laparoscopic approach in many centers. Methods: We retrospectively reviewed medical records of all patients at the 6 th department (Hepatobiliary Unit) of the 1 st affiliated hospital of Harbin Medical University who underwent elective LLR (n=102) or OLR (n=198) from January 1 st , 2014 to November 1 st , 2017. Patient demographics, diagnosis, operation type, operative duration, estimated blood loss, blood transfusion requirement pathology, length of hospital stay, ICU stays and complications were compared between laparoscopic and open approach. Hospital billing data were collected for each case to determine the mean hospital costs per case. Conclusion: Our study justifies that LLR is safe with remarkably better clinical benefits as well cost advantage to some extent. Short operating duration, short hospital stay, lower chances for ICU need, less blood loss, less blood transfusion requirement, and low occurrence of complications are benefits offered by the laparoscopic procedure.

show abstract

“…The II-VI compound semiconductor, Cd1-xZnxTe, is an important high resistance semiconductor applications due to ternary compound, resulting in superior sensitivity and large bandgap allowing room temperature operation [1]. However, CdZnTe crystals Polarization effect was found under the influence of such high doses of X-rays [2]. Furthermore, space charge mechanism of defects in CZT detector can be obtained, which could guide the manufacture of CZT detector.…”

Section: Introductionmentioning

confidence: 99%

Calculation of the internal electric field distribution which are exposed to extremely high X-ray radiation doses inside the CdZnTe detectors

Luo,

Zhang,

et al. 2023

International Conference on Electronic Materials and Information Engineering (EMIE 2023)

View full text Add to dashboard Cite

Breakthroughs in the Management of Hepatocellular Carcinoma: Celebrating 50 Years of the Liver Cancer Study Group of Japan

Cited by 3 publications

References 26 publications

ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway

ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway

Cost and Clinical Efficacy of Laparoscopic vs. Open Approach in Liver Resection

Calculation of the internal electric field distribution which are exposed to extremely high X-ray radiation doses inside the CdZnTe detectors

Contact Info

Product

Resources

About