Breast adenoid cystic carcinoma: a report of seven cases and literature review

Abstract

Background Primary adenoid cystic carcinoma (ACC) of breast is rarely seen clinically. It is a special subtype of triple-negative breast cancer characterized by low expression of Ki-67, low malignant potential, slow progression and favorable prognosis. To date, treatment for this disease is controversial and no consensus is reached. We analyzed clinical manifestations and pathological characteristics of seven primary breast ACC cases and reported in combination with literature review to promote understanding, diagnosis and treatment of this disease. Case presentation We collected seven breast ACC cases pathologically diagnosed and treated in Department of breast surgery of the First Affiliated Hospital of China Medical University from January 2015 to December 2018. We organized and summarized the clinical, imaging, pathological and prognostic information and performed statistical analysis. The median age was 60 years (ranging from 54 to 64 years). Tumors of all patients were detected by immunohistochemistry. Molecular types were mostly triple negative (4/7), and Ki-67 expression was low (5/7). Lymph node metastases were absent in all patients received axillary lymph node surgery. Median follow-up time was 39 months (ranging from 25 to 68 months). There was no occurrence of relapse, distant metastasis or death. Conclusion Breast ACC is accompanied with favorable diagnosis, which is different from typical triple-negative breast cancer. Accurate diagnosis of ACC is particularly important.

Solid basal adenoid cystic carcinoma of the breast: A case report and literature review

“…Tumors are mostly solitary, and multiple tumors are rare. [10,11] The tumor in this case was located in the areolar area of the left breast at 4 o'clock, which is consistent with literature reports. Radiographically, breast AdCC often presents as a well-defined lobulated mass with unclear or blurred borders that may be accompanied by microscopic calcification.…”

“…In addition, differentiation of sebaceous cells can also be seen. [10] Basal-like cells usually express CK5, CK5/6, CK14, and CK17, while myoepithelial cells express p63, actin, calcium-binding protein, and S-100. Luminal cells expressed CK7, EMA, CEA, and CD117.…”

“…[38] AdCC is often considered a histological subtype of TNBC, implying that endocrine therapy is not unnecessary. [10]…”

Adjuvant Radiotherapy in Primary Adenoid Cystic Carcinoma of Trachea- A Case Series

“…After squamous cell carcinoma, ACC is the second most common tracheal malignant neoplasm [1]. ACC In conclusion, based on the presentation of these three cases, we can conclude that surgical resection with reconstruction followed by postoperative adjuvant radiotherapy is the best modality of treatment for primary…”

“…Tracheal tumors are exceedingly rare; the incidence rate of primary tracheal tumors is less than 0.2 per 100,000 people [1]. As opposed to benign conditions, maximum tracheal cancers are malignant [2].…”