Breast Calcifications in Ehlers–Danlos Syndrome

Abstract

A 52-year-old Caucasian woman with Ehlers-Danlos syndrome (EDS) presented for mammography as part of the NHS Breast Screening Programme. A focus of dense calcifications was seen in the left breast. Core biopsy showed stromal calcification. The patient insisted on removal of the abnormal area. The wide local excision showed stromal calcification identical to that seen in the core biopsy. Clinicians should be aware of EDS patients presenting with breast stromal calcifications and this fact should be taken into account when investigating such lesions.

Calcinosis cutis

“…35 The pattern of inheritance may be autosomal dominant or autosomal recessive. 36 Collagen metabolism disorders lead to enhanced cutaneous elasticity, skin fragility, and hypermobile joints. Skin changes include molluscoid pseudotumors (fleshy herniations forming at pressure points or in scarred areas) and calcified spheroids (focal subcutaneous calcification).…”