Breast Cancer and HIV: State of the Art and Practical Implications

Lasagna, Angioletta; Zuccaro, Valentina; Sacchi, Paolo; Pagnucco, Layla; Ferraris, Elisa; Armani, G; Rizzo, Gianpiero; Tancredi, Richard; Pedrazzoli, Paolo

doi:10.1007/s42399-021-00950-z

Cited by 1 publication

(1 citation statement)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interplay between HIV infection and BC has been a focal point of medical research, reflecting the complexities inherent in the intersection of infectious diseases and cancer epidemiology [ 13 ]. Initially, during the early stages of the HIV epidemic, BC incidence among PLWH was reported to be lower than in the general population.…”

Section: Epidemiological and Demographic Considerationsmentioning

confidence: 99%

Navigating the Nexus: HIV and Breast Cancer—A Critical Review

Marino,

Pavone,

Martorana

et al. 2024

IJMS

View full text Add to dashboard Cite

Despite significant advances in the management of antiretroviral therapy (ART), leading to improved life expectancy for people living with HIV (PLWH), the incidence of non-AIDS-defining cancers, including breast cancer, has emerged as a critical concern. This review synthesizes current evidence on the epidemiology of breast cancer among HIV-infected individuals, highlighting the potential for an altered risk profile, earlier onset, and more advanced disease at diagnosis. It delves into the molecular considerations underpinning the relationship between HIV and breast cancer, including the role of immunosuppression, chronic inflammation, and gene expression alterations. Additionally, it examines the complexities of managing breast cancer in the context of HIV, particularly the challenges posed by ART and anticancer agents’ cross-toxicities and drug–drug interactions. The review also addresses survival disparities, underscoring the need for improved cancer care in this population. By identifying gaps in knowledge and areas requiring further research, this review aims to illuminate the complexities of HIV-associated breast cancer, fostering a deeper understanding of its epidemiology, molecular basis, and clinical management challenges, thereby contributing to better outcomes for individuals at the intersection of these two conditions. This narrative review systematically explores the intersection of HIV infection and breast cancer, focusing on the impact of HIV on breast cancer risk, outcomes, and treatment challenges.

show abstract

Section: Epidemiological and Demographic Considerationsmentioning

confidence: 99%