Breast Cancer and Other Second Neoplasms after Childhood Hodgkin's Disease

Bhatia, Smita; Robison, Leslie L.; Oberlin, Odile; Greenberg, Mark; Bunin, Greta R.; Fossati-Bellani, Franca; Meadows, Anna T.

doi:10.1056/nejm199603213341201

Cited by 842 publications

(497 citation statements)

References 41 publications

Supporting

Mentioning

459

Contrasting

Unclassified

Order By: Relevance

“…19 Follow up of 1380 children with HD aimed at determining the risk of occurrence of secondary neoplasms has shown that irradiation in childhood is associated with the highest risk for development of radiation-induced breast cancer. 8 Similar findings have been reported by Clemons et al, 20 establishing that the highest risk of developing breast cancer is by irradiation between puberty and the age of 30.…”

Section: Discussionsupporting

confidence: 79%

“…Breast cancer was the most common solid tumor (standardized incidence ratio 75.3; 95 percent confidence interval, 44.9-118.4), with an estimated actuarial incidence in women that approached 35 percent (95 percent confidence interval, 17.4-52.6 percent) by 40 years of age. 8 To solve this problem, scientific research in recent years has focused on the following areas:…”

Section: Background and Aimmentioning

confidence: 99%

See 1 more Smart Citation

Radiation-induced breast cancer in women with Hodgkin's disease

Александрова¹,

Mihaylova²,

Sergieva³

et al. 2014

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

Hodgkin's disease Materials and methods:Thirty-nine cases of women with BC that developed after treatment for HD in puberty or adolescence were analyzed retrospectively. The median age at initiation of treatment for HD was 12.9 years (9-21). The median age at diagnosis of the second malignancy -breast carcinoma was 32.4 years (22.9-39). Results:The distribution of patients according to the clinical T stage of breast cancer was as follows: 11 patients with T1 stage BC (28%), 22 with T2 stage (56%) and 6 with stage T3 (16%). Prevalent were tumors localized in the lateral breast quadrants. The observed 5 year survival was 95%. Conclusion:The risk of solid tumors, especially breast cancer, is high among women with HD disease who were treated with radiotherapy in their childhood. In this article, we propose a specific mathematical age formula which could be used as predictive equation when the age of the treatment for HD is in the range between 9 and 21 years. Systematic screening for breast cancer in these patients would be significantly important for their health and could improve their survival.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Background and Aimmentioning

confidence: 99%

Radiation-induced breast cancer in women with Hodgkin's disease

Александрова¹,

Mihaylova²,

Sergieva³

et al. 2014

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

“…40 However, in other reports, the median time of survival for secondary NHL was only 2.5 months. 41 Despite the large sample size and long follow-up of the SEER-9 registry cohort, our study has several limitations that should be considered while interpreting results. As the registry has no information on biologic features of primary malignancies, diagnosis of secondary hematological malignancies may be overestimated.…”

Section: Discussionmentioning

confidence: 94%

Secondary hematopoietic malignancies in survivors of childhood cancer

Rihani

Bazzeh

Faqih

et al. 2010

Cancer

View full text Add to dashboard Cite

BACKGROUND: Studying secondary hematological malignancies in a large cohort of patients can help predict risks and trends associated with current therapies. METHODS: The authors analyzed data from the Surveillance, Epidemiology, and End Resultsecondary 9 (SEER-9) database on patients with a primary malignancy (diagnosed before the age of 20 years) between 1973 and 2005 who developed a secondary hematological malignancy. Primary cancer and histological subtype, incidence, risk factors, outcomes, and changes in risk patterns of secondary hematological malignancies were analyzed for 1973 to 1985, 1986 to 1995, and 1996 to 2005. Standardized incidence ratios (SIRs) of observed to expected cancers were calculated. RESULTS: Of 34,867 patients with a histology-confirmed primary malignancy, 111 developed secondary hematological malignancies (median, 44 months). Lymphoma was the commonest primary cancer (n ¼ 47). The main histological subtype of secondary hematological malignancy was acute myeloid leukemia (AML) (49%), which had the shortest median latency time and the worst 5-year survival (18% AE 5.3%; P ¼.044). Secondary Hodgkin lymphoma had the best 5-year survival (83% AE 15%). The 5-year overall survival for patients with secondary hematological malignancies was 31% AE 4.7%. The risk of secondary AML steadily increased from 1986 to 2005, whereas SIRs for acute lymphoblastic leukemia did not change over time. Non-Hodgkin lymphoma, the second most common secondary hematological malignancy, occurred at a median of 112 months, and its risk steadily increased over time periods. CONCLUSIONS: Childhood cancer survivors are at increased risk of developing secondary hematological malignancies, particularly secondary AML. This risk has continued to rise even in recent years, emphasizing the need to study other factors contributing to secondary hematological malignancies and closely monitor these patients. Cancer 2010;116:4385-94.

show abstract

“…Two patients devel- It has been well documented that radiation therapy can induce secondary malignancies at the site of exposure. 2,42,43 In our analysis, Patients 1 and 6 received radiotherapy for local control of the primary OS in addition to systemic chemotherapy, before the development of SMN (fibrosarcoma and maxillary astrocytoma, respectively) that arose in the radiation field. Patient 13 received external beam radiation (3500 cGy) at age 1 year for his retinoblastoma.…”

Section: Discussionmentioning

confidence: 99%

“…A significant amount of information regarding second malignancies following treatment of Hodgkin disease, [1][2][3] retinoblastoma, 4 -6 and acute lymphoblastic leukemia (ALL) 7 is available because a good cure rate has been achieved for many years, resulting in many long-term survivors.…”

mentioning

confidence: 99%

Second malignant neoplasms in long‐term survivors of osteosarcoma

Aung

Görlick

Shi

et al. 2002

Cancer

View full text Add to dashboard Cite

BACKGROUNDThe authors investigated the incidence and relative risk of secondary malignant neoplasms in long‐term survivors of osteosarcoma.METHODSA comprehensive list of 509 patients with primary osteosarcoma treated at our institution between February 1973 and March 2000 was identified. All study patients received chemotherapy and/or surgery on one of six different protocols (T4, 5, 7, 10, 12, and CCG‐7921/POG‐9351). Chemotherapy was scheduled for up to 40 weeks with some variations in the actual treatment period and consisted of various combinations of the following agents: high‐dose methotrexate, doxorubicin, bleomycin, cyclophosphamide, dactinomycin, vincristine, cisplatin, and ifosfamide.RESULTSSecondary malignant neoplasms (SMN) occurred in 14 of 509 patients. Only one had pulmonary metastasis at diagnosis and subsequent multiple recurrences that required thoracotomies and further modification of the chemotherapy regimen. The median age at diagnosis for osteosarcoma was 16.6 years (range, 3.1–74.4 years). The median follow‐up was 5.2 years (range, 0.1–25.0 years). The time interval from diagnosis of the primary osteosarcoma to the development of SMN was 1.3–13.1 years (median, 5.5; 95% confidence interval [CI], 3.6–9.6). The most common SMN occurred in the central nervous system (n = 4): anaplastic glioma, meningioma, high‐grade glioma, and maxillary astrocytoma. There were two cases of acute myeloid leukemia and one case each of myelodysplastic syndrome, non‐Hodgkin lymphoma, high‐grade pleomorphic sarcoma, leiomyosarcoma, fibrosarcoma, breast carcinoma, and mucoepidermoid carcinoma. The overall 5 and 10‐year cumulative incidences of SMNs were 1.4% ± 1.1% and 3.1% ± 1.8%. The standardized incidence ratio was 4.6 (95% CI, 2.53–7.78, P = 0.00001) for the cohort and 3.64 (95% CI, 1.82–6.52, P = 0.0007) when patients with a history of retinoblastoma or Rothmund‐Thomson syndrome were excluded.CONCLUSIONSThe overall incidence of secondary malignancies in long‐term survivors of osteosarcoma was significantly higher than the expected incidence of cancer in the general population. However, the standardized incidence ratios were much lower than those reported for Hodgkin disease and retinoblastoma. Although additional follow‐up is warranted, the successes of current treatment regimens consisting of intensive, high‐dose chemotherapy in combination with topoisomerase II inhibitors outweigh the risks. Cancer 2002;95:1728–34. © 2002 American Cancer Society.DOI 10.1002/cncr.10861

show abstract

Breast Cancer and Other Second Neoplasms after Childhood Hodgkin's Disease

Abstract: The risk of solid tumors, especially breast cancer, is high among women who were treated with radiation for childhood Hodgkin's disease. Systematic screening for breast cancer could be important in the health care of such women.

Cited by 842 publications

References 41 publications

Radiation-induced breast cancer in women with Hodgkin's disease

Radiation-induced breast cancer in women with Hodgkin's disease

Secondary hematopoietic malignancies in survivors of childhood cancer

Second malignant neoplasms in long‐term survivors of osteosarcoma

Contact Info

Product

Resources

About