Breast cancer and pregnancy: Why special considerations prior to treatment are needed in multidisciplinary care

Zhang, Mingdi; Zhou, Jing

doi:10.5582/bst.2021.01187

Cited by 2 publications

(2 citation statements)

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“…The flowchart of searching strategy and study selection is shown in Table 1. Forty‐seven articles were strongly in favour of performing SLNB in PrBC, 2,4,6,13–56 4 articles were partially in favour, 57–60 2 articles were partially against 61,62 and 10 articles were strongly against SLNB in PrBC patients 3,5,10,63–69 . Sub‐analysis based on type of study showed that out of 47 articles which were strongly in favour of SLNB, 11 were prospective cohorts or RCTs, 5 were retrospective case series or case reports, 25 were review articles and 6 articles were guidelines.…”

Section: Resultsmentioning

confidence: 99%

Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update

Bothou,

Margioula‐Siarkou,

Petousis

et al. 2023

Eur J Clin Investigation

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BackgroundPregnant patients diagnosed with breast cancer (PrBC) may receive substantially different treatments compared to general population, considering that certain treatment options cannot be applied during pregnancy due to their potential harmful effects to the foetus. Regarding the use of sentinel lymph node biopsy (SLNB) in pregnant patients, potential concerns include foetal harm from radiation exposure, possible teratogenic effects of blue dyes and maternal anaphylaxis to isosulfan.ObjectiveThe main objective of the present systematic review is to summarize and present current knowledge and up‐to‐date evidence about the safety and efficacy of SLNB in PABC.MethodsMEDLINE, Google Scholar and UpToDate databases were searched up to 22 January 2023. Articles studying the safety and effectiveness of SLNB in patients for PrBC were eligible for inclusion in the present review.ResultsIn total, 63 articles that met the inclusion criteria were included in this study. Forty‐seven articles were strongly in favour of performing SLNB in PABC, 4 articles were partially in favour, 10 articles were strongly against and 2 articles were partially against performing SLNB in PABC. Sub‐categorization based on type of study showed that the majority of studies in favour were of higher level of evidence than those against. Furthermore, there were overall 12 studies reporting on outcomes. There were overall 382 women with PrBC that underwent SLNB. Full data were reported for 237 cases. Overall live birth rate was 95.8%, while overall neonatal complication rate was 3.4%.No case of maternal side effects or anaphylactic reaction, maternal death, stillbirth and neonatal death was reported (0%).ConclusionsSentinel lymph node biopsy seems to be safe and effective technique for breast cancer during pregnancy.

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Section: Resultsmentioning

confidence: 99%

Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update

Bothou,

Margioula‐Siarkou,

Petousis

et al. 2023

Eur J Clin Investigation

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“…The appearance on US is a low echogenic mass with irregular edges attached to a liquid, which presents central necrosis or cystic degeneration, due to the blood demand for tumor growth (30). If accompanied by microcalcifications, it may indicate breast cancer, unlike macrocalcifications, which are physiological (36,37,38). Combined with mammography, it generates an increase of 15.5% in the MRI screening rate for ipsilateral cancer and 3.9% for contralateral cancer.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

Pregnancy Associated with Breast Cancer: a review of the literature

Talah,

Lopes

2023

JHS

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Goal: to expose the main concepts of Breast Cancer diagnosed during pregnancy, presenting its risk and protective factors, patient profile and diagnosis. Literature Review: Pregnancy-Associated Breast Cancer (CMAG) is a breast cancer disease that affects patients during the first year after pregnancy. CMAG reaches its peak close to the fourth decade of life. There are factors that can be both risk and protective, such as reproductive behavior. Women who conceived 3 years ago have a 2.66 times higher risk compared to those who gave birth 10 years ago, just as a first pregnancy at age 30 can reduce the risk by 25% for all CMAGs. Breastfeeding, unlike reproductive behavior, is restricted to protect the patient, reducing the risk by up to 4.3% every 12 months, adding 7% to this value per pregnancy. The most prevalent Pregnancy-Associated Breast Cancers are those with negative hormone receptors, therefore Triple Negative and HER-2 positive. Both have an advanced staging pattern, high Ki67 index and Invasive Ductal Carcinoma (IDC) histology. Within the CMAG histological classifications, CDI corresponds to 71-100% of cases. Clinical findings in the breast include thickening of the skin, secretion of purulent fluids or blood, inflammatory and lymphatic changes.Pregnancy-Associated Breast Cancer has tropism for vascular tissues and adjacent lymph nodes, causing 2.5 times more metastases than other tumors. Conclusion: There is a need to expand the field of research on Pregnancy-Associated Breast Cancer, given the magnitude of exponential growth presented by this pathology in recent decades.

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Breast cancer and pregnancy: Why special considerations prior to treatment are needed in multidisciplinary care

Cited by 2 publications

References 85 publications

Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update

Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update

Pregnancy Associated with Breast Cancer: a review of the literature

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