Breast cancer cases of female patients under 35ï¿½years of age in Togo: A series of 158ï¿½cases

Darré, Tchin; Tchaou, Mazamaesso; Folligan, K; Amadou, Abdoulatif; N’timon, B.; Sonhaye, Lantam; Aboubakari, Abdoul‐Samadou; Amégbor, Koffi; Akpadza, Koffi; Koura, Gado Napo

doi:10.3892/mco.2017.1461

Cited by 7 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found an annual frequency of 3.28 cases of breast cancer in men, significantly lower than that of breast cancer in women in our country [ 9 ]. Breast cancer in men accounts for less than 1% of breast cancer diagnoses in the United States [ 10 ].…”

Section: Discussionmentioning

confidence: 95%

“…This finding was also made in a study done on female breast cancer. Indeed, the African population in general and that of Togo in particular is young and would explain in part its average ages [ 8 , 9 ]. The young age of our subjects could perhaps also be explained by the existence of genetic mutations in this population.…”

Section: Discussionmentioning

confidence: 99%

“…Other presentations included thickening of the skin, nipple retraction, and lymphadenopathy [ 2 ]. Breast cancer in men presents in most cases as a subareolar swelling, nipple retraction, or bloody discharge [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Breast cancer in men seems to have a poorer prognosis than in women [ 8 , 12 ]. Tumor sizes as well as lymph node involvement are two important prognostic factors in human breast cancer [ 9 ]. Men with a tumor of 2 to 5 cm have a 40% increased risk of death compared to those whose tumor is less than 2 cm in maximum diameter [ 10 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…In general, the prognosis for men with breast cancer is similar to that for women [ 9 , 25 , 26 ]. The therapeutic strategy for the management of cancers in men is similar to that in women [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Male Breast Cancer in Togo: Imaging and Clinicopathological Findings

Darré

Tchaou

Djiwa

et al. 2020

International Journal of Breast Cancer

Self Cite

View full text Add to dashboard Cite

Background. Breast cancer in men is a rare condition, often diagnosed late. The purpose of this study was to describe its epidemiological, histopathological, and radiographic aspects in Togo. Materials and Methods. This was a descriptive retrospective study on cases of breast cancer in humans diagnosed histologically at the Laboratory of Anatomy Pathological and Imagery of the University Hospital in Lomé, over a period of 25 years (1995 to 2019). The parameters studied were epidemiological, anatomopathological, and imaging. Results. Eighty-two (82) cases were diagnosed, an annual frequency of 3.28 cases. The mean age was 45±2.5 years; the range was 27-63 years. The family history of 47 patients (57.32%) was known. Carcinomas represented the predominant histological group with predominantly nonspecific invasive carcinoma (87.5%). These cancers were diagnosed at late stages (75.71% grade II). They were mainly of luminal B profile (38.75%) and associated with mutations of the BRCA2 and BRCA1 genes in 14.63% of the cases. The lesions were classified ACR 5 in 61.5% (11/18). Two cases of breast angiosarcoma were diagnosed by the identification of CD31 markers and factor VIII in immunohistochemistry. Hormone therapy such as tamoxifen was prescribed in all luminal patients (43 patients). Radiotherapy was administered to 15 patients (18.3%), with acute toxicity in 20% of the cases. After a median follow-up of 36 months, the evolution was complete remission in 27 patients (32.93%). Conclusion. Breast cancer in men is rare, often diagnosed late with a poor prognosis.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Male Breast Cancer in Togo: Imaging and Clinicopathological Findings

Darré

Tchaou

Djiwa

et al. 2020

International Journal of Breast Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

Comparative analysis of breast cancer characteristics in young premenopausal and postmenopausal women in Ghana

Bosompem,

Yorke,

Buckman

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Breast cancer is increasingly common among young women in Ghana. BCa is heterogeneous with unique traits that impact causes, prognostic, and predictive outcomes of patients before and after menopause. However, limited evidence exists on differences between young premenopausal (YPM) and postmenopausal cases in Ghana. This study compared breast tumour characteristics between YPM women (under 35 years) and postmenopausal women. We conducted a prospective cross-sectional study involving 140 BCa-diagnosed women at the Breast Care Clinic of Komfo Anokye Teaching Hospital (KATH), Kumasi from November 2019 to June 2021. Thirty-one (22.1%) of participants were YPM and 109 (77.9%) were postmenopausal. The median ages for YPM and postmenopausal were 32.0 (range: 25.0–35.0) and 57.0 (48.0–86.0) respectively. Invasive carcinoma was the most common histological type (97.1%). Left tumour location was the most frequent in both groups (51.6% for YPM and 51.8% for postmenopausal). Lumps detected were frequently in the outer upper quadrant in both groups (61.3% and 56.0%). The majority of the YPM women (80.7%) and postmenopausal women (87.0%) had stage III and IV diseases. Most YPM (64.5%) and postmenopausal women (64.4%) exhibited triple-negative breast cancer (TNBC). Both YPM 13 (56.6%) and postmenopausal participants 40 (56.3%) exhibited a predominantly partial response to neo-adjuvant chemotherapy but YPM women (21.7%) experienced disease progression than the postmenopausal women (12.7%). The study highlights consistent tumour characteristics and advanced clinical stages at diagnosis in both groups with a higher prevalence of TNBC. TNBC and HER2+ subtypes respond better to Anthracycline-based neoadjuvant chemotherapy. Establishing Breast Care Clinics in district and regional hospitals for early detection is crucial and further studies are warranted to understand the higher TNBC prevalence in black Africans and re-evaluate breast education programs to address the persistently late presentations.

show abstract

Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study

Ntirenganya

Twagirumukiza

Bucyibaruta

et al. 2021

International Journal of Breast Cancer

View full text Add to dashboard Cite

Background. Breast cancer (BC) is the most prevalent cancer in women and the leading cause of women’s cancer-related deaths and morbidity worldwide. In Rwanda, BC incidence is increasing with an unacceptably high mortality rate in premenopausal women. Objectives. The purpose was to identify modifiable BC risk factors and assess associations between common breast cancer risks factors and molecular subtypes in premenopausal women in Rwanda. Methods. This was a case-control study. Premenopausal women with histological confirmation of BC and frequency-matched for age controls were recruited. A preestablished questionnaire was administered to both cases and controls for sociodemographics, BC probable risk factors, and clinical and pathological characteristics. BC was classified into luminal A, luminal B, HER2-type, basal-like (triple negative), and unclassified molecular subtypes by immunohistochemistry (IHC). Odds ratio (OR) and 95% confidence interval (CI) were estimated using multivariate logistic regression analysis. Results. 340 participants were recruited into the study (170 cases vs. 170 controls). The median age was 39 years. The majority of cases presented at advanced stages of the disease (51.2% in stages III and IV) and had invasive ductal carcinoma (98.2%). 60.6% had subtypes of poor prognosis (HER2 enriched 14.7%, triple negative 12.9%, and unclassified 32.9%). Alcohol intake AOR = 3.73 , 95 % C I 2.19 − 6.32 , p < 0.001 , obesity/overweight in adolescence or early adulthood AOR = 10.86 , 95 % C I 4.82 − 24.4 , p < 0.001 , history of primary infertility AOR = 33.8 , 95 % C I 3.5 − 321.5 , p = 0.002 , nulliparity AOR = 3.75 , 95 % C I 1.61 − 8.75 , p = 0.002 , and a history of benign breast disease AOR = 6.06 , 95 % C I 1.19 − 30.73 , p = 0.03 were associated with the occurrence of premenopausal breast cancer. There was no significant difference between risk factor stratification per molecular subtype. Conclusion. Several reproductive, environmental, and lifestyle risk factors have been identified to be associated with premenopausal BC. Among them, alcohol intake and obesity/overweight during adolescence/early adulthood can be modified. Interventions targeting alcohol consumption and obesity/overweight in adolescents and young adults may decrease the incidence of premenopausal breast cancer.

show abstract

Breast cancer cases of female patients under 35ï¿½years of age in Togo: A series of 158ï¿½cases

Cited by 7 publications

References 25 publications

Male Breast Cancer in Togo: Imaging and Clinicopathological Findings

Male Breast Cancer in Togo: Imaging and Clinicopathological Findings

Comparative analysis of breast cancer characteristics in young premenopausal and postmenopausal women in Ghana

Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study

Contact Info

Product

Resources

About