Breast cancer cells are sensitized by piperine to radiotherapy through estrogen receptor-α mediated modulation of a key NHEJ repair protein- DNA-PK

In-silico Discovery of Potential Mycobacterium tuberculosis Cell Division Protein FtsZ Inhibitors: A Natural Ligand Piperine-Derived 3-Point Pharmacophore Screening and Structure-Guided Blind Docking Study

“…Through our computational investigation, we want to find drugs with strong interactions, advantageous binding modes, and promising inhibitory potential against M. tuberculosis FtsZ. [18][19][20] The combination of blind docking and pharmacophorebased screening offers a thorough approach to the in-silico identification of FtsZ inhibitors. The computational endeavor yielded valuable insights that could facilitate additional experimental validation and lead to the development of novel anti-tubercular medicines with lower resistance profiles and increased efficacy.…”