Breast cancer characteristics at diagnosis and survival among Arab–American women compared to European– and African–American women

Alford, Sharon Hensley; Schwartz, Kendra; Soliman, Amr S.; Johnson, Christine Cole; Gruber, Stephen B.; Merajver, Sofía D.

doi:10.1007/s10549-008-9999-z

Cited by 32 publications

(21 citation statements)

References 13 publications

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“…They addressed that these biomarkers, found through differences characteristic, are useful for better treatment, and surgical or radio or hormone therapy 45–48…”

Section: Surveillance Epidemiology and End Resultsmentioning

confidence: 99%

Identification of Biomarkers for Breast Cancer Using Databases

Lee

Moon

2016

J Cancer Prev

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Breast cancer is one of the major causes of cancer death in women. Many studies have sought to identify specific molecules involved in breast cancer and understand their characteristics. Many biomarkers which are easily measurable, dependable, and inexpensive, with a high sensitivity and specificity have been identified. The rapidly increasing technology development and availability of epigenetic informations play critical roles in cancer. The accumulated data have been collected, stored, and analyzed in various types of databases. It is important to acknowledge useful and available data and retrieve them from databases. Nowadays, many researches utilize the databases, including The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Surveillance, Epidemiology and End Results (SEER), and Embase, to find useful informations on biomarkers for breast cancer. This review summarizes the current databases which have been utilized for identification of biomarkers for breast cancer. The information provided by this review would be beneficial to seeking appropriate strategies for diagnosis and treatment of breast cancer.

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“…They addressed that these biomarkers, found through differences characteristic, are useful for better treatment, and surgical or radio or hormone therapy 45–48…”

Section: Surveillance Epidemiology and End Resultsmentioning

confidence: 99%

Identification of Biomarkers for Breast Cancer Using Databases

Lee

Moon

2016

J Cancer Prev

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“…However, this finding is not unique insofar as other reports have observed similarly poorer outcomes affecting African Americans with breast cancer, soft tissue sarcoma, and gynecologic malignancies. [18][19][20][21] Further investigations are necessary to determine whether these differences are a result of tumor biology, differences in screening and access to care, the type of care received, or other factors or combinations of factors. One of the limitations of the current study is that only those patients with primary, nonmetastatic small cell carcinoma of the lung for the years 1988 through 1997 were included as the analyzable population, because for the periods before and after, the use of whole-brain radiotherapy was not recorded in the SEER database.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the use of prophylactic cranial irradiation in small cell lung cancer

Patel

Macdonald

Suntharalingam

2009

Cancer

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BACKGROUND: Prophylactic cranial irradiation has been used in patients with small cell lung cancer to reduce the incidence of brain metastasis after primary therapy. The purpose of this study was to evaluate the effects of prophylactic cranial irradiation (PCI) on overall survival and cause‐specific survival. METHODS: A total of 7995 patients with limited stage small cell lung cancer diagnosed between 1988 and 1997 were retrospectively identified from centers participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program. Of them, 670 were identified as having received PCI as a component of their first course of therapy. Overall survival and cause‐specific survival were estimated by the Kaplan‐Meier method, comparing patients treated with or without prophylactic whole‐brain radiotherapy. The Cox proportional hazards model was used in the multivariate analysis to evaluate potential prognostic factors. RESULTS: The median follow‐up time was 13 months (range, 1 month to 180 months). Overall survival at 2 years, 5 years, and 10 years was 23%, 11%, and 6%, respectively, in patients who did not receive PCI. In patients who received PCI, the 2‐year, 5‐year, and 10‐year overall survival rates were 42%, 19%, and 9%, respectively (P = <.001). The cause‐specific survival rate at 2 years, 5 years, and 10 years was 28%, 15%, 11%, respectively, in patients who did not receive PCI and 45%, 24%, 17%, respectively, in patients who did receive PCI (P = <.001). On multivariate analysis of cause‐specific and overall survival, age at diagnosis, sex, grade, extent of primary disease, size of disease, extent of lymph node involvement, and PCI were found to be significant (P = <.001). The hazards ratios for disease‐specific and all cause mortality were 1.13 and 1.11, respectively, for those not receiving PCI. CONCLUSIONS: Significantly improved overall and cause‐specific survival was observed in patients treated with prophylactic cranial irradiation on unadjusted and adjusted analyses. This study concurs with the previously published European experience. Prophylactic cranial irradiation should be considered for patients with limited stage small cell lung cancer. Cancer 2009. © 2008 American Cancer Society.

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“…One understudied ethnic minority group of women is Arab-Americans, in part because traditionally they have often been grouped with Caucasians. The largest concentration of Arab-Americans outside of the Middle East is in Metropolitan Detroit, MI [6]. Schwartz et al [7] found that these women in Metropolitan Detroit were less likely to have ever had a mammogram than all Michigan women and had a lower prevalence of mammography compared to other racial/ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Knowledge of Breast Cancer Screening and Prevention among Arab-American Women in Michigan

et al. 2010

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Arab-American women are more likely to be diagnosed with advanced staged breast cancer. We analyzed data from 100 women utilizing a breast cancer literacy assessment tool aimed at understanding functional literacy levels about breast-self exams (BSE), clinical breast exams (CBE), and mammograms. The educational program improved women's knowledge of BSE (OR=0.15; 95% CI=0.04, 0.50) and CBE (OR=0.15; 95% CI=0.04, 0.54), more for women with higher education. Consideration of women's educational status is an important factor in planning educational programs to improve knowledge on breast cancer screening and prevention in this minority population.

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Breast cancer characteristics at diagnosis and survival among Arab–American women compared to European– and African–American women

Cited by 32 publications

References 13 publications

Identification of Biomarkers for Breast Cancer Using Databases

Identification of Biomarkers for Breast Cancer Using Databases

Evaluation of the use of prophylactic cranial irradiation in small cell lung cancer

Evaluating the Knowledge of Breast Cancer Screening and Prevention among Arab-American Women in Michigan

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