The rapid development of technologies in biomedical research has enriched and broadened the range of medical equipment. Magnetic resonance imaging, ultrasonic imaging, and optical imaging have been discovered by diverse research communities to design multimodal systems, which is essential for biomedical applications. One of the important tools is photoacoustic multimodal imaging (PAMI) which combines the concepts of optics and ultrasonic systems. At the same time, earlier detection of breast cancer becomes essential to reduce mortality. The recent advancements of deep learning (DL) models enable detection and classification the breast cancer using biomedical images. This article introduces a novel social engineering optimization with deep transfer learning-based breast cancer detection and classification (SEODTL-BDC) model using PAI. The intention of the SEODTL-BDC technique is to detect and categorize the presence of breast cancer using ultrasound images. Primarily, bilateral filtering (BF) is applied as an image preprocessing technique to remove noise. Besides, a lightweight LEDNet model is employed for the segmentation of biomedical images. In addition, residual network (ResNet-18) model can be utilized as a feature extractor. Finally, SEO with recurrent neural network (RNN) model, named SEO-RNN classifier, is applied to allot proper class labels to the biomedical images. The performance validation of the SEODTL-BDC technique is carried out using benchmark dataset and the experimental outcomes pointed out the supremacy of the SEODTL-BDC approach over the existing methods.