Breast cancer clinicopathological presentation, gravity and challenges in Eritrea, East Africa: Management practice in a resource-poor setting

Tesfamariam, Asmerom; Gebremichael, A; Mufunda, J

doi:10.7196/samj.6829

Cited by 19 publications

(25 citation statements)

References 15 publications

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“…Clinical and pathological factors will be discussed on the basis of articles from 7 African countries: Republic of South Africa (RSA) [24], Egypt [25,26,27], Nigeria [28], Eritrea [29], Morocco [30], Cameroon [31,32], and Rwanda [33]. …”

Section: Clinical and Pathological Presentation Of Bcmentioning

confidence: 99%

A Review on Breast Cancer Care in Africa

et al. 2015

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Background: The global incidence of breast cancer (BC) is rising, especially in low- and middle-income countries. The purpose of this review is to summarize existing publications on BC care in Africa. Patients and Methods: A systematic search in MEDLINE and smaller databases was carried out to identify African studies on BC treatment, and an additional PubMed search was performed for relevant topics on BC care. Results: A total of 219 publications, mainly from North and West Africa, were found by systematic search. We also selected articles on BC epidemiology, risk factors, clinical presentation, and cancer control in Africa. Conclusions: Publications on BC treatment are mostly from hospital case series. Evidence on treatment from prospective randomized trials that address the specific characteristics of African patients is lacking. The epidemiologic data shows rising incidences in Africa. The prevalence of risk factors is changing by age group, geographic region, and over time. The clinical picture of BC differs from that of Western countries due to the high proportion of young patients (on account of the African population with a high proportion of young people) and late presentation. Global collaborative efforts are needed to address the rising need for improved BC care in Africa.

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Section: Clinical and Pathological Presentation Of Bcmentioning

confidence: 99%

A Review on Breast Cancer Care in Africa

et al. 2015

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“…16 Nevertheless, Iraq, categorized as a middle-income country by WHO/Eastern Mediterranean Regional Office, 17 documents far better prognostic indicators than those recorded in low-resource settings such as Eritrea in eastern Africa, where two-thirds of the cases are detected in advanced stages; the mean duration from the onset of symptoms to the time of seeking medical advice approaches 3 years. 18 …”

mentioning

confidence: 99%

Breast Cancer Among Iraqi Women: Preliminary Findings From a Regional Comparative Breast Cancer Research Project

Alwan

2016

JGO

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“…16 In Eritrea, 80 of the 82 women who were observed received surgical intervention as their only treatment because there are no chemotherapy or radiotherapy options available nationally. 12 Nguefack et al 10 in Cameroon observed 42 women for breast cancer over a 3-year period, and nearly all were treated with some form of surgery (92.9%), despite the majority of patients presenting with stage III disease; 79% of patients received neoadjuvant chemotherapy to downstage tumors and therefore allow surgical excision and closure to occur. 10 This suggests a possible regional difference in approach to multidisciplinary breast cancer care, as well as a chasm in cultural attitudes toward surgical options, because very few women in Eritrea and Cameroon are refusing mastectomies in comparison with their counterparts in Nigeria.…”

Section: Surgerymentioning

confidence: 99%

“…6,8,15,17 Furthermore, the ability to assess surgical margins for tumor-free tissue is often not feasible, and postoperative follow-up is low. 12,16 …”

Section: Surgerymentioning

confidence: 99%

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Surgical Management of Breast Cancer in Africa: A Continent-Wide Review of Intervention Practices, Barriers to Care, and Adjuvant Therapy

Sutter

Slinker

Balumuka

et al. 2017

JGO

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Breast cancer has emerged as a leading cancer among women in Africa, necessitating improved understanding of its management across the continent. Although previous studies have described regional trends in therapy, this review aims to summarize continent-wide management and focus specifically on surgical interventions. Current literature shows that the rates of surgery, chemotherapy, and radiation therapy vary across different countries and institutions, indicating the need for greater use of standardized cancer treatment guidelines. Surgery, primarily modified radical mastectomy, is the most common form of therapy described. When chemotherapy is offered, the limited availability and cost of treatment lead to high rates of interruption and premature termination of cycles. Few patients have access to radiation or hormonal therapy because these treatments are not available in many countries. Significant delays in seeking treatment are common and contribute to patients presenting with advanced disease. Although limited infrastructure favors surgical management, interventions to improve early detection behavior, provide timely referrals to medical care, and initiate early treatment with access to clinically justified neo-adjuvant and adjuvant therapy are key to improving prognosis.

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Breast cancer clinicopathological presentation, gravity and challenges in Eritrea, East Africa: Management practice in a resource-poor setting

Cited by 19 publications

References 15 publications

A Review on Breast Cancer Care in Africa

A Review on Breast Cancer Care in Africa

Breast Cancer Among Iraqi Women: Preliminary Findings From a Regional Comparative Breast Cancer Research Project

Surgical Management of Breast Cancer in Africa: A Continent-Wide Review of Intervention Practices, Barriers to Care, and Adjuvant Therapy

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