Breast cancer: descriptive profile of 80 women attending breast cancer care in the Department of General and Digestive Surgery of CHU-YO

Abstract

IntroductionBreast cancer is a common cause of death among women in Burkina Faso. The aim of this study was to determine a descriptive profile of 80 women and establish a description of risk factors associated with breast cancer in these women.MethodsThis cross-sectional study recruited women with breast cancer in Ouagadougou. Teaching Hospital Yalgado Ouedraogo in Burkina Faso from January 2015 to February 2016. We have collected data on socio-demographic characteristics, reproductive status, clinical information, treatment and molecular characteristics.ResultsThe average age of the study population was 48.2±12.4 years. Family history of breast cancer was reported in 18.75% of the studied participants against 16.25% family history for other types of cancer. Patients from urban areas represented 87.5% of our studied population with 58.75% of household, multiparous (55.0%), no aborts status (56.2%), post-menopausal women (53.75%), no oral contraception (63.75%), regular menstrual cycle (71.25%) and the prevalence of obesity was 12.5%. The clinical and molecular characteristics showed that left-sided breast cancer accounted for 51.25 %, high grade (II and III) represented 93.75 % of cases and the majority of tumors were infiltrating ductal carcinomas (93.75%) with stages III and IV accounted for 50.0%.ConclusionThis study described the distribution of risks factors in a population of breast cancer women. Although more research are needed to support these findings, a clear understanding of risk factors associated with breast cancer would contribute to significantly reduce breast cancer incidence and mortality in Burkina Faso.

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) variants and breast cancer risk in Burkina Faso

“…Several well-known risk factors for breast cancer development are family history of breast cancer, advanced age, early puberty, late menopause, nulliparity, obesity and hereditary transmission of certain predisposition genes, including the BRCA1 and BRCA2 genes (involved in 5-10% of breast cancer cases) and the CHEK2, TP53, ATM and PTEN genes [1,3,4]. In Burkina Faso, previous studies have described the distribution of breast cancer risk factors in a population [5] and shown that multiparity is associated with a decreased risk of breast cancer [6]. Genetic analyses targeting relevant exons in BRCA1 genes have also been performed [7].…”

Epidemiological Situation and Medical Management of Gynaecological and Breast Cancers from 1998 to 2018 in West Africa: A Systematic Review

“…The education for self-examination and awareness of the population would allow earlier diagnosis. Lastly, breast cancer was diagnosed at late presentation (stage II, III and IV) constituted 93.75 % of cases [40]. In Burkina Faso, patients often resort to traditional medicine or other treatments before coming to a consultation.…”

Identification of BRCA1/2 p.Ser1613Gly, p.Pro871Leu, p.Lys1183Arg, p.Glu1038Gly, p.Ser1140Gly, p.Ala2466Val, p.His2440Arg variants in women under 45 years old with breast nodules suspected of having breast cancer in Burkina Faso

“…In Burkina Faso (one of the west African countries) breast cancer is being responsible for 17.7% of women's deaths [7]. A recent study provide preliminary information about breast cancer risk decreasing with multiparity among women in Burkina Faso [8,9]. Genetic and non-genetic factors are involved in the etiology of breast cancer.…”

“…The available information about breast cancer in Burkina Faso, regarding the histo-pathological characteristics of tumors and parity risk factors, is limited [8,9], with few specific records about genetic features [8,9,21].…”