Breast cancer diagnosis in women with subglandular silicone gel-filled augmentation implants.

Fajardo, Laurie L.; Harvey, Janet; McAleese, Kelly A.; Roberts, Catherine C.; Granstrom, Per

doi:10.1148/radiology.194.3.7862991

Cited by 67 publications

(33 citation statements)

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“…Clinical case series have reported a tendency towards a delayed breast cancer diagnosis among women with breast implants (Gottlieb et al, 1984;Leibman and Kruse, 1990;Silverstein et al, 1990a;Carlson et al, 1993;Fajardo et al, 1995). Overall, epidemiological studies have not been able to confirm such reports.…”

Section: Discussionmentioning

confidence: 97%

“…However, the issue of potential delay in breast cancer diagnosis in the augmented breast has been raised, since breast implants are radiopaque and this influences the sensitivity of mammography (Eklund et al, 1988;Hayes et al, 1988;Silverstein et al, 1992). Clinical reports have suggested a possible delay and difficulties in the diagnosis of breast cancer (Leibman and Kruse, 1990;Silverstein et al, 1990a;Carlson et al, 1993;Fajardo et al, 1995), but most epidemiological studies have not supported a delay in diagnosis or impaired survival among women with breast implants (Birdsell et al, 1993;Deapen et al, 2000).…”

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confidence: 99%

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Stage of breast cancer at diagnosis among women with cosmetic breast implants

et al. 2003

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Concern has been raised about the potential delay in breast cancer diagnosis in the augmented breast. We linked a cohort of 2955 women, who received cosmetic breast implants in Denmark during the period 1973 -1997 with the Danish Cancer Registry and the Danish Breast Cancer Cooperative Group register. We identified 23 incident cases of invasive breast cancer diagnosed subsequent to breast implantation. We randomly selected 11 controls for each case from the Danish Breast Cancer Cooperative Group's register, and obtained detailed information on all study subjects about surgery, histopathology and stage of breast cancer at diagnosis, intended adjuvant treatment according to trial protocols and overall survival. We found that women with breast implants on average were diagnosed with breast cancer at the same stage as controls. Significantly more women with breast implants had tumour cells in the surgical margins according to the Danish Breast Cancer Cooperative Group's data. There was no significant difference in overall survival between the two groups after an average of 6.4 years of follow-up. Based on this limited number of women with breast cancer subsequent to breast augmentation, breast implants do not appear to delay the diagnosis of breast cancer, and no evidence of impaired survival after breast cancer diagnosis in augmented women was found.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Stage of breast cancer at diagnosis among women with cosmetic breast implants

et al. 2003

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“…The Eklund technique is routinely used to aid in visualizing more of the breast tissue [30]. The review by Uematsu discusses the reported sensitivity of the implant displacement technique of 67% compared with standard implant compression of 6% [31]. The CC, MLO, and lateral views can be incorporated to ensure that all of the remaining tissue anterior to the implant is imaged.…”

Section: Implantsmentioning

confidence: 99%

A review of breast imaging following mastectomy with or without reconstruction in an outpatient community center

Destounis¹,

Morgan²,

Arieno³

et al. 2011

Breast Cancer

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Despite developments in surgical technique, radiation treatment, and chemotherapeutic agents, tumor recurrence and distant disease have remained a major concern in breast cancer management. Breast imaging after mastectomy in the screening arena remains a controversial topic for breast imagers. Many feel the yield of finding a recurrent cancer with imaging in the asymptomatic patient is too low to be beneficial; others believe imaging should be performed on these patients as the risk of recurrence exists. Patients after a mastectomy procedure are considered high risk and, when they present with clinical symptoms, will require evaluation by the radiologist. In this diagnostic/symptomatic scenario, imaging becomes the routine and current imaging tools, such as mammography, ultrasound, and magnetic resonance imaging (MRI), can easily be incorporated to diagnose recurrent cancer. Our facility has a large population of patients that undergo mastectomy after a carcinoma diagnosis as well as a number of patients that have undergone a mastectomy procedure because of their high-risk status (whether family history or genetic predisposition). A certain percentage of these patients have proceeded to reconstructive surgery. We image these patients routinely as part of our screening protocol. Over the years we have become familiar with the appearance of remaining tissue along the chest wall after mastectomy as well as the reconstructed breasts. This familiarity is important as the imaging of these patients with mammography and other modalities available today can be challenging. This manuscript will discuss the benefits and some limitations surrounding imaging these patients, in both the asymptomatic and symptomatic scenarios, as well as what imaging protocols can be integrated within a facility's standard evaluation.

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“…2 Silicone implants may obscure mammographic images of the breast tissue and interfere with the interpretation of mammograms, thus hindering detection of breast cancer. [18][19][20] One study estimated that augmentation mammoplasty obscures 22% to 83% of breast tissue on mammography. 21 MRI has been shown to be more sensitive than mammography for identifying coincidental malignancy in women with breast implants.…”

Section: Evaluation Of the Augmented Breastmentioning

confidence: 99%