Breast cancer genetics in African Americans

Olopade, Olufunmilayo I.; Fackenthal, James D.; Dunston, Georgia M.; Tainsky, Michael A.; Collins, Francis S.; Whitfield-Broome, Carolyn

doi:10.1002/cncr.11019

Cited by 156 publications

(103 citation statements)

References 39 publications

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“…Several studies report that the prevalence of significant mutations is similar in black and white women with a family history of breast cancer, suggesting that black and white women would be expected to benefit equally from predictive genetic testing. 38,39 The low rates of ordering genetic tests for Huntington disease among minority-serving physicians may reflect early studies suggesting a lower prevalence of Huntington disease among blacks compared with whites, although more recent data report similar prevalence rates across white and black populations. 40 -42 Although minority patients may benefit from genetic testing as much as nonminority patients, if minority patients are sicker and have more complex health needs than majority patients, these health issues may crowd out the provision of genetic services.…”

Section: Discussionmentioning

confidence: 99%

Differential use of available genetic tests among primary care physicians in the United States: results of a national survey

Shields

Burke

Levy

2008

Genetics in Medicine

135

115

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Section: Discussionmentioning

confidence: 99%

Differential use of available genetic tests among primary care physicians in the United States: results of a national survey

Shields

Burke

Levy

2008

Genetics in Medicine

135

115

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show abstract

“…A number of small prevalence surveys in Black women have yielded varying results with respect to BRCA prevalence and penetrance specific to AA women Frank et al 2002;Gao et al 2000;Haffty et al 2005;John et al 2007;Kanaan et al 2003;Malone et al 2006;Mefford et al 1999;Nanda et al 2005;Olopade et al 2003;Pal et al 2004Pal et al , 2008Panguluri et al 1999;Pegoraro et al 2003;Shen et al 2000). This lack of knowledge is perpetuated by low rates of participation by AA women in clinical and research BRCA genetic counseling and testing (Armstrong et al 2005;Halbert et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Updating and refining a study brochure for a cancer registry-based study of BRCA mutations among young African American breast cancer patients: lessons learned

Vadaparampil

Pal

2010

J Community Genet

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The aim of the present study was to update, refine, and evaluate a study brochure to promote participation in a population-based study of BRCA mutations among AA women with a personal history of early-onset breast cancer. A multi-step approach was used to develop this brochure and included: (1) feedback from community members (through a Community Advisory Panel (CAP)) to develop and refine the study brochure, (2) pilot testing of materials with the target audience, and (3) review of pilot testing results with the CAP. Based on the feedback received at each step, the study brochure was refined. In phase 1, the major changes included emphasizing the concept of leaving a legacy and family, using the terms Black and women of color, and use of patient vignettes and photos. In phase 2, attraction and cultural acceptability were identified as two areas for improvement in the study brochure. These results demonstrate that involvement of community members and target study population in the development of a study-specific brochure can provide invaluable feedback to optimize recruitment strategies. This approach can be readily adapted to develop study recruitment materials for individuals from a variety of cultural and ethnic backgrounds.

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“…Genetic susceptibility to breast cancer has been identified in various races and ethnicities [5][6][7][8][9][10][11][12]. However, the majority of research on genetic cancer risk assessment (GCRA) for hereditary breast and ovarian cancer has been conducted in predominantly non-Latino white samples, and most ethnic minority studies focus on the prevalence of BRCA mutations and genetic testing attitudes and motivation among African American cohorts [12][13][14][15][16][17][18][19][20]. Although the few studies focused on Latinos and GCRA have found that Latinos may have low knowledge [21][22][23] and negative perceptions [24] of cancer genetic testing, others have identified positive attitudes and interest in participating in cancer genetic services and testing [23,25].…”

Section: Introductionmentioning

confidence: 99%

Social‐cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer

et al. 2008

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Objectives: As Latinos are a growing ethnic group in the United States, it is important to understand the socio-cultural factors that may be associated with cancer screening and prevention in this population. The socio-cultural factors that may affect preparedness to undergo genetic cancer risk assessment (GCRA) deserve particular attention. The pre-GCRA period can provide insight into variables that may influence how medically underserved Latinas, with limited health resources and access, understand hereditary cancer information and subsequently implement cancer risk management recommendations. This study explores social, cognitive and cultural variables in Latinas prior to undergoing GCRA.Methods: The study sample consisted of low-income, underserved Latinas referred for GCRA because of a personal and/or family history of breast or ovarian cancer. Acculturation, cancer-specific fatalism, self-efficacy and social support were assessed prior to GCRA.Results: Fifty Latinas (mean age 5 40.177.7) completed instruments; 86% had invasive cancer, 78% spoke primarily Spanish and 61% were of Mexican ancestry. Low levels of acculturation (n 5 50, mean 5 9.075.8) and cancer-specific fatalism (n 5 43, mean 5 5.673.2), but relatively high self-efficacy (n 5 49, mean 5 40.977.8) and social support (n 5 49, mean 5 37.378.7) were reported. Cancer-specific fatalism and self-efficacy were inversely correlated (r 5 À0.47, p 5 0.002). Those over age 38 at the time of cancer diagnosis reported higher acculturation (mean 5 11.477.2, p 5 0.02) and social support (mean 5 40.571.2, p 5 0.05).Conclusions: These findings suggest that medically underserved Latinas may already possess some of the necessary skills to successfully approach the GCRA process, but that special attention should be given to cultural factors.

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Breast cancer genetics in African Americans

Cited by 156 publications

References 39 publications

Differential use of available genetic tests among primary care physicians in the United States: results of a national survey

Differential use of available genetic tests among primary care physicians in the United States: results of a national survey

Updating and refining a study brochure for a cancer registry-based study of BRCA mutations among young African American breast cancer patients: lessons learned

Social‐cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer

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