Breast Cancer Genetics Knowledge and Testing Intentions among Nigerian Professional Women

Ngene, Samuel Osobuchi; Adedokun, Babatunde; Adejumo, Prisca Olabisi; Olopade, Olufunmilayo I.

doi:10.1007/s10897-017-0194-4

Cited by 6 publications

(2 citation statements)

References 51 publications

(79 reference statements)

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“… 16 To bridge this knowledge gap, the authors developed nurse genetic counselors' curriculum for training in genetic risk assessment and provide counseling service to patients with breast cancer in three collaborating tertiary health institutions in Nigeria. Also, we developed a study on how demographics, knowledge, attitude, and practices may influence individuals' willingness to pay for cancer genetics, 13 especially in the developing countries 17 to test price point toward integrating genetic services in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing

Adejumo

Aniagwu

Awolude

et al. 2023

JCO Global Oncology

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PURPOSE Cancer genetic testing (CGT), a pathway to personalized medicine, is also being embraced in Nigeria. However, little is known about the influence of demographics and perceptions on individuals' willingness to access and pay for CGT. This study assessed patients' willingness to undergo CGT in southwest Nigeria as a catalyst for sustainable Cancer Risk Management Program. METHODS This was a cross-sectional study using semistructured questionnaire to interview 362 patients with cancer and 10 referred first-degree relatives between July 2018 and February 2020. Participants from three Nigerian teaching hospitals—University College Hospital, Ibadan, Lagos State University Teaching Hospital, Lagos, and Lagos University Teaching Hospital, Lagos, received genetic counseling and had subsequent CGT. Primary outcomes were willingness to undergo CGT in determining cancer risk and the willingness to pay for it. Ethical approval was from appropriate ethics committees of participating hospitals. Data were analyzed with SPSS version 22. Univariate comparison of categorical variables was performed by χ2 test, multivariate analysis by logistic regression. RESULTS The participants from University College Hospital (56.2%), Lagos State University Teaching Hospital (26.3%), and Lagos University Teaching Hospital (17.5%) were mostly female (98.4%). Mean age was 48.8 years ± 11.79. Three hundred twenty-two (86.6%) patients and first-degree relatives were willing to take the test, of whom 231 (71.1%) were willing to pay for it. more than half (53.6%) of the participants were willing to pay between N10,000 and N30,000, which is less than $100 US dollars. Sociodemographic variables and willingness to test showed no association ( P > .05). Education and ethnicity were found to be associated with their willingness to pay for CGT ( P ≤ .05). CONCLUSION Learning clinically relevant details toward cancer prevention informs health-related decisions in patients and relatives, a motivator for willingness to pay for genetic testing in low- and middle-income countries. Increased awareness may influence outcomes of cancer risk management.

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Section: Introductionmentioning

confidence: 99%

Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing

Adejumo

Aniagwu

Awolude

et al. 2023

JCO Global Oncology

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“…Hereditary breast cancer is caused by germline mutations that occur in BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. 82 The discovery of these genes has permitted their classification into two groups, namely high-penetrance and lowpenetrance that interact with other genes and/or environmental factors to cause disease. The two most common breast cancer genes are BRCA1 and BRCA2, both of which are required for homologous DNA repair.…”

Section: Brain Tumoursmentioning

confidence: 99%

Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population

et al. 2020

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The study of hereditary cancer, which accounts for~10% of cancer cases worldwide is an important subfield of oncology. Our understanding of hereditary cancers has greatly advanced with recent advances in sequencing technology, but as with any genetic trait, gene frequencies of cancer-associated mutations vary across populations, and most studies that have located hereditary cancer genes have been conducted on European or Asian populations. There is an urgent need to trace hereditary cancer genes across the Arab world. Hereditary disease is particularly prevalent among members of consanguineous populations, and consanguineous marriages are particularly common in the Arab world. There are also cultural and educational idiosyncrasies that differentiate Arab populations from other more thoroughly studied groups with respect to cancer awareness and treatment. Therefore, a review of the literature on hereditary cancers in this understudied population was undertaken. We report that BRCA mutations are not as prevalent among Arab breast cancer patients as they are among other ethnic groups, and therefore, other genes may play a more important role. A wide variety of germline inherited mutations that are associated with cancer are discussed, with particular attention to breast, ovarian, colorectal, prostate, and brain cancers. Finally, we describe the state of the profession of familial cancer genetic counselling in the Arab world, and the clinics and societies dedicated to its advances. We describe the complexities of genetic counselling that are specific to the Arab world. Understanding hereditary cancer is heavily dependent on understanding population-specific variations in cancer-associated gene frequencies.

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University students’ knowledge and readiness to practice genomic nursing in Nigeria

Adejumo

Kolawole

Ojo

et al. 2021

International Journal of Africa Nursing Sciences

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Breast Cancer Genetics Knowledge and Testing Intentions among Nigerian Professional Women

Cited by 6 publications

References 51 publications

Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing

Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing

Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population

University students’ knowledge and readiness to practice genomic nursing in Nigeria

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