Breast Cancer in a Caribbean Population in Transition: Design and Implementation of the Atabey Population-Based Case-Control Study of Women in the San Juan Metropolitan Area in Puerto Rico

Rosario-Rosado, Rosa V.; Nazario, Cruz M.; Hernández-Santiago, Johan; Schelske‐Santos, Michelle; Mansilla-Rivera, Imar; Ramírez-Marrero, Farah A.; Ramos-Valencia, Gilberto; Climent, Consuelo; Nie, Jing; Freudenheim, Jo L.

doi:10.3390/ijerph17041333

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…IBC tumors with a triple-negative (ER-/PR-/Her2-) concordance have been associated with the worst outcome 23 . In the general population of non-IBC BC in Puerto Rico, triple-negative tumors account for 9.5% of cases 24 . Importantly, in our study, an alarming 15.7% of IBC patients presented with triple-negative disease (ER-/PR-/Her2-).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Inflammatory Breast Cancer in Hispanic Women from Puerto Rico

Quirindongo-Rivera¹,

Rullán-Varela²,

Underill³

et al. 2022

J. Cancer

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Background: Breast cancer (BC) is the most diagnosed cancer and the leading cause of cancer death among women in Puerto Rico (PR). Inflammatory breast cancer (IBC) is considered the most aggressive BC subtype. This study characterized the IBC population of Hispanic women living in Puerto Rico and aimed to estimate the IBC survival rate using data from the Puerto Rico Central Cancer Registry (PRCCR). Methods: This is a retrospective, population-based study using the PRCCR database and the Health Insurance Linkage Database (PRCCR-HILD). We analyzed data from patients that were diagnosed with IBC from January 1, 2008 to December 31, 2018. Patients were identified using the International Classification of Diseases for Oncology, 3rd edition (ICD-O-3) site codes C50.0-C50.9 and histology code 8530. Variables such as age at diagnosis, marital status, health insurance, geographic area of residence, staging variables, tumor receptor subtypes, treatment received, and overall survival (OS) were studied. Statistical analysis methods were employed to describe the population, estimate survival curves and examine the risk of dying. Results: The data of 51 patients were included. The mean age at diagnosis of IBC in the current study was 59 years old. A total of 62.8% of patients had no metastases at diagnosis and 64.7% were diagnosed with stage III disease. Most tumors presented with ER+/PR+/Her2-(21.6%), or a triple negative (ER-/PR-/Her2-, 15.7%) tumor concordance. The OS during the first year was 66% (90% CI: 0.54-0.76), whereas 36 months post-diagnosis was at a low 39% (90% CI: 0.27-0.59). The triple-negative subtype had the worst survival at 36 months (36% [90% CI: 0.11-0.62]). This study revealed through Cox regression analysis that women with stage IV disease and those with ER-/PR-tumor subtype have a higher risk of dying (HR 4.99;] and HR 4.74; [90% CI: 1.88-11.95]), respectively. Conclusions: Our results suggest that the Puerto Rican IBC patient population presents unique characteristics. This is the first research to describe the patient profile and characteristics of women diagnosed with IBC in PR. This research increases awareness about this lethal disease in PR.

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Section: Discussionmentioning

confidence: 99%

Characterization of Inflammatory Breast Cancer in Hispanic Women from Puerto Rico

Quirindongo-Rivera¹,

Rullán-Varela²,

Underill³

et al. 2022

J. Cancer

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“…Recruited were women between 30 and 79 years of age who were residents of the metropolitan area of San Juan to participate in a population-based case control-study (ATABEY Study). The design and implementation have been described in detail elsewhere [27]. The study was approved by the University of Puerto Rico Medical Sciences Campus Institutional Review Board and by the IRB of all participating institutions.…”

Section: Methodsmentioning

confidence: 99%

Anthropometric Measures and Breast Cancer Risk among Hispanic Women in Puerto Rico

Ramírez-Marrero

Nazario

Rosario-Rosado

et al. 2021

Preprint

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While there is consistent evidence of increased risk of postmenopausal breast cancer associated with higher body mass index (BMI), higher adult weight gain and higher waist circumference in North American and European populations, there is little evidence for Hispanic women. Among Hispanic women in Puerto Rico (PR), breast cancer is the leading type of cancer, and leading cause of cancer related deaths. However, compared with the United States, breast cancer rates are lower but increasing more rapidly. Purpose: To determine associations between anthropometric characteristics and breast cancer risk in Hispanic women in PR. Methods: Data from a population-based case control study in the San Juan metropolitan region was used to examine associations between anthropometric measures and breast cancer risk, also considering menopausal status and hormone therapy (HT). Results: Among premenopausal women, BMI equal or higher than 25 kg/m2 and waist to height ratio (WHtR) of 0.53 or higher were associated with lower odds of breast cancer. For postmenopausal breast cancer, waist circumference of 86.4 cm or higher, WHtR of 0.57 or higher, waist to hip ratio of 0.84 or greater, and height of 150 cm or taller were associated with lower odds of breast cancer. Conclusion: Our study provides evidence that associations of risk with anthropometry may differ for Hispanic women. Future studies should include measures of fat and lean mass distribution to further understand anthropometric measures and breast cancer risk among Hispanic women.

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“…Engaging in regular physical activity is bene cial to breast cancer survivors in arresting this physical functioning decline, alleviating fatigue, increasing the quality of life, decreasing depression and anxiety, improving sleep, and decreasing the risk of mortality, among other bene ts [4,5,6,7,8]. Considering that most breast cancer survivors are 50 years of age or above [9,10,11], they also face the potential of limited physical capabilities that may occur in middle-to late-age. Like the general population, breast cancer survivors in the United States (U.S.) continue to show low adherence to national exercise standards [12].…”

Section: Introductionmentioning

confidence: 99%

Low-intensity endurance exercise increases physical functioning among breast cancer survivors: a randomized controlled trial

Mulero-Portela,

Colón-Santaella,

Rogers

et al. 2024

Preprint

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Purpose: This study assessed the effect of low- versus moderate-intensity endurance exercise on the physical functioning of women who are breast cancer survivors. Methods: Women who had completed treatment for breast cancer at stages 0 to III, aged 50 years and above, were randomly assigned to a low-intensity or moderate-intensity exercise group. Both groups participated in seven intervention sessions distributed over 26 weeks. Women were instructed to walk for 30 minutes five days a week. Flexibility, strengthening, and balance exercises were included for both groups. The Theory of Planned Behavior guided the interventions. Outcomes were assessed at baseline, post-intervention, and 12 months after baseline. The primary outcomes were PROMIS Physical Functioning, PROMIS Global Health, and the six-minute walk test. Results: Sixty-five of 101 women randomized (64.4%) completed the study. No statistically significant between-group differences were found at post-intervention or 12 months. In both exercise groups, statistically significant improvements were demonstrated for the PROMIS Physical Functioning at post-intervention (p = 0.01 for low intensity; p=.002 for moderate intensity), and the PROMIS Global Health physical health subscale (p = 0.001 for low intensity; p=.005 for moderate intensity). No statistically significant within-group changes were observed in the PROMIS Global Health mental subscale or the six-minute walk test. Conclusion: A seven-intervention session program at both low and moderate-intensity walking significantly improved physical functioning in breast cancer survivors. Implications for cancer survivors: Women who are breast cancer survivors aged 50 years and above who would like to increase their physical functioning, have the option of exercising at both low and moderate intensity. Trial registration number: ClinicalTrials.gov identifier: NCT02982564 Date of registration: December 5, 2016

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Breast Cancer in a Caribbean Population in Transition: Design and Implementation of the Atabey Population-Based Case-Control Study of Women in the San Juan Metropolitan Area in Puerto Rico

Cited by 7 publications

References 21 publications

Characterization of Inflammatory Breast Cancer in Hispanic Women from Puerto Rico

Characterization of Inflammatory Breast Cancer in Hispanic Women from Puerto Rico

Anthropometric Measures and Breast Cancer Risk among Hispanic Women in Puerto Rico

Low-intensity endurance exercise increases physical functioning among breast cancer survivors: a randomized controlled trial

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