Breast Cancer in Pregnancy: Avoiding Fetal Harm When Maternal Treatment Is Necessary

Cordeiro, Christina N.; Gemignani, Mph Mary L.

doi:10.1111/tbj.12780

Cited by 33 publications

(52 citation statements)

References 31 publications

(61 reference statements)

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“…Although there is a dearth of information on the relationship between PABC and non‐Caucasian race, one study has suggested a higher proportion of PABC cases among minority races . Although there is some debate in the literature, PABC is often associated with hormone receptor negative and HER2 enriched cancers …”

Section: Discussionmentioning

confidence: 99%

“…The postpartum period is variably defined in the literature, ranging from 1 to 5 years after a pregnancy . PABC is currently estimated to affect 1 in every 3000 breast cancer patients, with this incidence expected to rise as breast cancer among young women becomes more common, and greater numbers of women are choosing to delay childbearing …”

Section: Introductionmentioning

confidence: 99%

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Pregnancy‐associated breast cancer in a contemporary cohort of newly diagnosed women

et al. 2019

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Pregnancy‐associated breast cancer (PABC) refers to breast cancer (BC) diagnosed during pregnancy, lactation, or in the postpartum period. There is evidence that PABC is associated with a poorer prognosis, and that the development of the disease is influenced by the unique hormonal milieu of pregnancy. The purpose of this study was to investigate the clinicopathologic characteristics associated with PABC in a contemporary cohort of women with newly diagnosed BC. Our institutional Breast Cancer Database was queried for women diagnosed with BC between 2009‐2018 who had at least one full‐term pregnancy (FTP). Variables of interest included patient demographics and clinical and tumor characteristics. PABC was defined as breast cancer diagnosed within 24 months of delivery. Statistical analyses included Pearson's chi‐square and logistic regression. Out of a total of 2202 women, 46 (2.1%) had PABC. Median follow‐up in the total cohort was 5.5 years. After adjusting for age at first FTP, PABC was associated with younger age at diagnosis, older age at first FTP, non‐Caucasian race, BRCA positivity, presentation with a palpable mass, higher pathologic stage, higher histologic grade, and ER‐negative and triple‐negative receptor status. The association of PABC with non‐Caucasian race may be reflected in the increased proportion of triple‐negative breast cancers in the PABC group. PABC was also associated with older age at first FTP. As more women delay childbearing, risk for PABC may increase. Our findings suggest that women who become pregnant at older ages should be followed carefully during pregnancy and the postpartum period, especially if they are BRCA mutation carriers. The optimal approach for monitoring older women during pregnancy and the postpartum period is unclear.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pregnancy‐associated breast cancer in a contemporary cohort of newly diagnosed women

et al. 2019

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“…8 Surgical treatment is considered safe to be performed at any trimester of pregnancy, with mastectomy being the surgery of choice. 8,9 Whether to perform or not a sentinel lymph node biopsy during the procedure remains without consensus in the literature. 8 Chemotherapy can also be performed after the first trimester of pregnancy, taking care to avoid certain chemotherapeutic drugs such as methotrexate.…”

Section: Discussionmentioning

confidence: 99%

“…8 Chemotherapy can also be performed after the first trimester of pregnancy, taking care to avoid certain chemotherapeutic drugs such as methotrexate. 9 Radiotherapy, hormone therapy and use of monoclonal antibodies are contraindicated during pregnancy. 8,9…”

Section: Discussionmentioning

confidence: 99%

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Clinical, histological and radiological findings of invasive ductal carcinoma in a pregnant woman

Noronha¹,

Régis²,

Borges³

2019

IJRRT

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Pregnancy-associated breast cancer is defined as a breast cancer diagnosed during pregnancy or within one year postpartum. It is an under-studied entity, despite its increased incidence due to the tendency to extend the age of the first gestation.The major issue regarding breast cancer in pregnant women is the delay in diagnosis, both due to glandular and ductal hyperplasia typical of pregnancy, as well as the physician's uncertainty about the diagnostic approach, fearing harmful effects on the fetus, thus leading to a worse prognosis. We report the case of a pregnant patient with invasive ductal carcinoma, suspected by palpation during physical examination and confirmed after histological study of the fragment obtained by ultrasound-guided core biopsy, with subsequent staging with magnetic resonance imaging. The purpose of this report was to discuss the correct investigative management of a case of invasive ductal carcinoma associated with pregnancy, aiming at reducing morbidity and mortality.

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Pregnancy-Associated Breast Cancer

Rouzier¹,

Bourdet-Trefoux²,

Genin³

et al. 2019

Breast Diseases

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Breast cancer, along with cervical cancer, is one of the most commonly diagnosed cancers of pregnancy. Most would define gestational breast cancer as breast cancer that is diagnosed during pregnancy, lactation, and up to 12 months post-partum. The diagnostic and therapeutic implications in this clinical setting are special. These women typically present with a more advanced-stage disease that carries an associated poorer prognosis. Physicians thus are challenged to balance aggressive maternal care with appropriate modifications that will ensure fetal protection.

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Breast Cancer in Pregnancy: Avoiding Fetal Harm When Maternal Treatment Is Necessary

Cited by 33 publications

References 31 publications

Pregnancy‐associated breast cancer in a contemporary cohort of newly diagnosed women

Pregnancy‐associated breast cancer in a contemporary cohort of newly diagnosed women

Clinical, histological and radiological findings of invasive ductal carcinoma in a pregnant woman

Pregnancy-Associated Breast Cancer

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