Breast Cancer in the United Arab Emirates

Al-Shamsi, Humaid O.; Abdelwahed, Nadia; Al‐Awadhi, Aydah; As, Mohamed; Abyad, Amin; Rafii, Saeed; Afrit, Mehdi; Lababidi, Bilal Al; Abu-Gheida, Ibrahim; Sonawane, Yoginee Pundlik; Nijhawan, Neil A.; Haq, Urfan Ul; Dreier, Norbert; Joshua, Thanda Lucy Ann; Iqbal, Faryal; Yacoub, Tamer; Nawaz, Faisal A.; Jabbar, Dima Abdul; Tirmazy, Syed Hammad; Elshourbagy, D.; Hamza, Dina; Omara, M.A.; Madhi, Sawsan Abdul Salam Al; Ghazal, Hassan; Darr, Humaa; Muharrem, Oner; Vlamaki, Zoi; Kinge, Abdul Rahman El; Ramanathan, Dorai; Judah, Mohammed; Almahmeed, Taghreed; Ahmad, Mudhasir; Jonnada, Sai Babu; Almansoori, Nahla; Razek, Aly A; Al-Hamadi, Annett; Balalaa, Nahed; Jamali, Faek; Singarachari, Ramanujam Anugonda; Labban, Abdelrahman; Das, K.J. Maria; Luiten, Ernest J. T.; Abdelgawad, Tamer; Al-Khatib, Falah; Alrawi, Sadir; Jaafar, Hassan

doi:10.1200/go.22.00247

Cited by 10 publications

(17 citation statements)

References 45 publications

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“…The median age of the UAE population, according to 2021 data, was approximately 30 years overall. 6 In fact, the age-specific incidence rates for breast cancer among women illustrated in the 2021 UAE-NCR report are comparable to those reported in the United States; they rise steadily from age 25 years, cross the 100 per 100,000…”

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confidence: 74%

“…This may be primarily attributed to the UAE being a young nation populated mostly by expatriate, young residents. The median age of the UAE population, according to 2021 data, was approximately 30 years overall 6 . In fact, the age‐specific incidence rates for breast cancer among women illustrated in the 2021 UAE‐NCR report are comparable to those reported in the United States; they rise steadily from age 25 years, cross the 100 per 100,000 threshold between ages 40 and 49, and peak at ages 70–74 years 4,5 .…”

Section: Overall Population No (%) Emirati No (%) Non‐emirati No (%) ...mentioning

confidence: 88%

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Not only a Western world issue: Cancer incidence in younger individuals in the United Arab Emirates

Al‐Shamsi,

Musallam

2024

CA A Cancer J Clinicians

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Two important reports regarding cancer incidence in the United States 1 and globally 2 have been recently released. In summary, almost 20 million people worldwide were diagnosed with cancer in 2022, and almost 10 million died of their disease. 2 Lung cancer is the most common cancer globally, followed by female breast, colorectal, prostate, and stomach cancers. For women, breast cancer is the most common and is most often fatal; whereas, for men, the most common is lung cancer. 2 Cancer statistics from the United States released late last year indicated an alarming trend which was not covered in the global statistics: that colorectal and cervical cancers are increasing among individuals younger than 50 years and that colorectal cancer is now the first cause of cancer death among men and the second cause among women in this age group. 1 This is not an observation restricted to the United States; although the data are not as robust, increases in young-onset colorectal cancer have been documented from Chennai (India) to Korea. 3 Siegel et al. reported that, for three countries in Europe (Netherlands, Cyprus, and Norway), the increase in colorectal cancer incidence was twice as rapid as that in older adults. 3 Still, data are sparse when it comes to the Middle East and North African nations.Recent reports from the United Arab Emirates (UAE) demonstrate that the issue is indeed global. The UAE National Cancer Registry (UAE-NCR) records cancer incidence rates stratified by age,

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confidence: 74%

Section: Overall Population No (%) Emirati No (%) Non‐emirati No (%) ...mentioning

confidence: 88%

Not only a Western world issue: Cancer incidence in younger individuals in the United Arab Emirates

Al‐Shamsi,

Musallam

2024

CA A Cancer J Clinicians

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“…In UAE, cancer was found to be the third leading cause of death where breast cancer accounts for 21.4% (3). Therefore, breast cancer was ranked rst due to its prevalence, incidence, and mortality (3,4). The high burden of the disease prompts the medical community to explore and advance treatment options.…”

Section: Introductionmentioning

confidence: 99%

Physical Rehabilitation Program for Cardiorespiratory Health and Quality of Life among Breast Cancer Survivors in UAE: Protocol for a Randomized Control Trial.

Rashid,

Anwar,

Kandakurti

et al. 2024

Preprint

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Background Cancer is a medical condition where some cells of the body reproduce uncontrollably and metastasize to other parts of the body. The burden of the disease is significantly high both at the global and national levels. In UAE, cancer was found to be the third leading cause of death. Breast cancer has been ranked first due to its prevalence, incidence, and mortality in UAE. Breast cancer survivors have significantly poor cardiovascular tolerance which affects their Quality of Life (QoL), even after the carcinoma has been treated or removed. Thus, the protocol aims to analyze the changes in cardiovascular endurance and QoL domains for breast cancer survivors in the United Arab Emirates using a long-term 2-month physical rehabilitation. Methods A total of 60 breast cancer survivors would be included in the study using a randomized controlled allocation of a 2-month physical rehabilitation intervention program with three months follow up. The intervention would target the cardiovascular endurance component of the participants to improve their physical well-being and Quality of life ultimately. Discussion The findings of the study would have high clinical significance among the breast cancer survivors in UAE. The proposed physical rehabilitation program could be beneficial in improving cardiovascular endurance and thereby reduce the risk of mortality among the breast cancer survivors. In addition, the physiological benefits of the exercise program could improve their Quality-of-Life domains including physical, mental, and social well- being. On a larger view, it could also help to reduce the economic burden on the health system due to associated complications. Trial Registration: Clinical trial ID: NCT06013527. Registration date: 28 August 2023.

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“…Compared to the Western population, BCs have diverse clinical, pathological and molecular features including early onset, higher tumor grade, higher human epidermal growth factor receptor (HER)2 amplification rate, more aggressive subtypes and a lower rate of luminal subtype, in the GCC population ( 7 – 9 ). Evidence suggests that approximately 46.2% to 54% of BC patients are diagnosed at advanced disease stage ( 7 , 8 , 10 – 12 ), 23.3% to 28% are diagnosed with localized tumors while ≤2% with in-situ carcinoma ( 8 , 10 ). In the GCC region, the vast majority of BC cases (82.1% to 93%) have invasive ductal carcinoma (IDC) ( 7 , 8 ), and 19.2% to 29.5% have HER2 overexpression ( 7 , 8 , 12 ), while 14.3% to 26.9% have triple-negative BC (TNBC) ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…Evidence suggests that approximately 46.2% to 54% of BC patients are diagnosed at advanced disease stage ( 7 , 8 , 10 – 12 ), 23.3% to 28% are diagnosed with localized tumors while ≤2% with in-situ carcinoma ( 8 , 10 ). In the GCC region, the vast majority of BC cases (82.1% to 93%) have invasive ductal carcinoma (IDC) ( 7 , 8 ), and 19.2% to 29.5% have HER2 overexpression ( 7 , 8 , 12 ), while 14.3% to 26.9% have triple-negative BC (TNBC) ( 7 , 8 ). The average age of patients at the presentation of BC is at least a decade younger in the GCC population compared to the Western population (<48 years vs 60 years) ( 7 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

BRCA testing and management of BRCA-mutated early-stage breast cancer: a comprehensive statement by expert group from GCC region

Al-Shamsi,

Alwbari,

Azribi

et al. 2024

Front. Oncol.

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BReast CAncer (BRCA)1 and BRCA2 gene pathogenic variants account for most hereditary breast cancers (BC). Identification of BRCA mutations can significantly influence both prognosis and treatment outcomes. Furthermore, it enables the identification of individuals who are at heightened risk of developing BC due to inherited genetic mutations. Many developing countries rely on western guidelines for BRCA testing and BC management; however, there exist wide disparities in the prevalence of risk factors, availability of medical resources, and practice patterns. Guidelines tailored to specific regions can help mitigate healthcare variations, promote consistency in treatment, and aid healthcare providers in identifying effective therapies for improving patient outcomes. Hence, oncologists from the Gulf Cooperation Council (GCC) congregated virtually in March 2023 and reviewed existing data on the epidemiology of BC, BRCA mutations, practices and challenges associated with BRCA testing and management of BRCA mutated early-stage BC in the GCC region. They also provided insights on the real-world diagnostic and treatment practices and challenges in the GCC region in the BRCA-mutated early-stage BC domain and suggested some variations to international guidelines to aid their uptake in this region.

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Breast Cancer in the United Arab Emirates

Abstract: Creative Commons Attribution Non-Commercial No Derivatives 4.0 License Author affiliations and support information (if applicable) appear at the end of this article.

Cited by 10 publications

References 45 publications

Not only a Western world issue: Cancer incidence in younger individuals in the United Arab Emirates

Not only a Western world issue: Cancer incidence in younger individuals in the United Arab Emirates

Physical Rehabilitation Program for Cardiorespiratory Health and Quality of Life among Breast Cancer Survivors in UAE: Protocol for a Randomized Control Trial.

BRCA testing and management of BRCA-mutated early-stage breast cancer: a comprehensive statement by expert group from GCC region

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