Breast Cancer in the Very Young Patient: A Multidisciplinary Case Presentation

Mintzer, David M.; Glassburn, John R.; Mason, Bernard A.; Sataloff, Dahlia M.

doi:10.1634/theoncologist.7-6-547

Cited by 37 publications

(31 citation statements)

References 53 publications

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“…The disease is mainly found in postmenopausal women, given that about 75% of cases are diagnosed in women over 50 years of age. 1,2 Despite being a relatively uncommon condition, current statistics indicate an increase in the incidence of such tumors in young women. [1][2][3][4] The increased incidence of breast tumors in young patients may be related to behavioral factors such as changes in diet, exposure to exogenous and endogenous hormones and late age of first pregnancy.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Despite being a relatively uncommon condition, current statistics indicate an increase in the incidence of such tumors in young women. [1][2][3][4] The increased incidence of breast tumors in young patients may be related to behavioral factors such as changes in diet, exposure to exogenous and endogenous hormones and late age of first pregnancy. 5 A positive family history of breast cancer is also an important risk factor associated with the development of breast cancer in young women, as it can be related to the presence of a familial syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Breast cancer features in women under the age of 40 years

Eugênio

Souza

Chojniak

et al. 2016

Rev. Assoc. Med. Bras.

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Results:The mean age at diagnosis of primary breast cancer was 34 years. Only 11 patients (9.0%) had a family history of breast or ovarian cancer in first-degree relative. Ninety-two (92) patients sought medical attention after showing breast symptoms, and the presence of a palpable nodule was the main complaint. One hundred and twenty-two (122) primary tumors were diagnosed, of which 112 were invasive (95%). The most common histological type was invasive ductal carcinoma (73.8%). Luminal B was the predominant molecular subtype (42.6%). Ultrasonography was positive in 94.5% of the cases and the most common finding were nodules (94.8%). At mammography, the malignancy was observed in 92.8% and the presence of suggestive calcifications was the dominant feature. The MRI was positive in 98% of patients, and mass lesions were the most common. Conclusion: Most cases of breast cancer diagnosed in patients under the age of 40 years, in our population, had symptoms at diagnosis and tumor with more aggressive biological behavior. Despite the ultrasound has been the most widely used method, we found improved characterization of breast lesions when also used mammography and MRI.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breast cancer features in women under the age of 40 years

Eugênio

Souza

Chojniak

et al. 2016

Rev. Assoc. Med. Bras.

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“…Mammography in the past was reported as much less sensitive as ultrasound and magnetic resonance imaging (MRI) due to the increased density of the younger breast [2][3][4][5][6][7][8][9][10][11]. With advances in film technology, the introduction of digital equipment and increasing regulatory requirements improving the quality of mammography, small series have reported better results [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Time for a re-evaluation of mammography in the young? Results of an audit of mammography in women younger than 40 in a resource restricted environment

Taylor

Basro

Apffelstaedt

et al. 2011

Breast Cancer Res Treat

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Mammography in younger women is considered to be of limited value. In a resource restricted environment without access to magnetic resonance imaging (MRI) and with a high incidence of breast cancer in the young, mammography remains an important diagnostic tool. Recent technical advances and better regulation of mammography make a reassessment of its value in these conditions necessary. Data of all the mammograms performed at a tertiary hospital and private breast clinic between January 2003 and July 2009 in women less than 40 years of age were collected. Indications were the presence of a mass, follow-up after primary cancer therapy, and screening for patients perceived at high risk due to a family history or the presence of atypical hyperplasia. Data acquired were as follows: Demographics, prior breast surgery, indication for mammography, outcome of mammography, diagnostic procedures, and their results. Of 2,167 mammograms, 393 were performed for a palpable mass, diagnostic mammography. In these, the overall cancer detection rate was 40%. If the mammography was reported as breast imaging reporting and data system (BIRADS(®)) 5 versus BIRADS(®) 3 and 4 versus BIRADS(®) 1 and 2, a final diagnosis of malignancy was established in 96, 48, and 5%, respectively. Of 367 mammograms done for the follow-up after primary treatment of breast cancer, seven cancers were diagnosed for a detection rate of 1.9%. Of 1,312 mammograms performed for screening, the recall rate was 4%; the biopsy rate 2%, and the cancer diagnosis rate 3/1,000 examinations. In contrast to past series, this series has shown that recent advances in mammography have made it a useful tool in the management of breast problems in young women, notably in a resource-restricted environment. Women for screening should be selected carefully.

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“…Demers et al (2000) suggested that exposure to organochlorines was related to breast cancer aggressiveness and prognosis as indicated by axillary lymph node involvement and tumor size. Exposure to chemicals such as PBDE might play an important role in breast cancer progression for these younger women (Lai et al 2002;Mintzer et al 2002). Although we were not able to evaluate genetic characteristics of the study population, an association between breast cancer and contaminated fish consumption may be limited to women with a specific genotype.…”

Section: Discussionmentioning

confidence: 99%

Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin.

McElroy¹,

Kanarek²,

Trentham‐Dietz³

et al. 2004

Environ Health Perspect

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In Wisconsin, consumption of Great Lakes fish is an important source of exposure to polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ethers (PBDEs), and other halogenated hydrocarbons, all of which may act as potential risk factors for breast cancer. We examined the association between sport-caught fish consumption and breast cancer incidence as part of an ongoing population-based case-control study. We identified breast cancer cases 20-69 years of age who were diagnosed in 1998-2000 (n = 1,481) from the Wisconsin Cancer Reporting System. Female controls of similar age were randomly selected from population lists (n = 1,301). Information about all sport-caught (Great Lakes and other lakes) fish consumption and breast cancer risk factors was obtained through telephone interviews. After adjustment for known and suspected risk factors, the relative risk of breast cancer for women who had recently consumed sport-caught fish was similar to women who had never eaten sport-caught fish [relative risk (RR) = 1.00; 95% confidence interval (CI), 0.86-1.17]. Frequency of consumption and location of sport-caught fish were not associated with an increased risk of breast cancer. Recent consumption of Great Lakes fish was not associated with postmenopausal breast cancer (RR = 0.78; 95% CI, 0.57-1.07), whereas risk associated with premenopausal breast cancer was elevated (RR = 1.70; 95% CI, 1.16-2.50). In this study we found no overall association between recent consumption of sport-caught fish and breast cancer, although there may be an increased breast cancer risk for subgroups of women who are young and/or premenopausal.

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Breast Cancer in the Very Young Patient: A Multidisciplinary Case Presentation

Cited by 37 publications

References 53 publications

Breast cancer features in women under the age of 40 years

Breast cancer features in women under the age of 40 years

Time for a re-evaluation of mammography in the young? Results of an audit of mammography in women younger than 40 in a resource restricted environment

Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin.

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