Breast cancer in Tripoli/Libya: 1990-2008.

elhabbash, manal mousa; Al-Windi, A.

doi:10.1200/jco.2010.28.15_suppl.e12052

Cited by 2 publications

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“…The occurrence of breast cancer in our study is strongly associated with young age with nearly 73% of cases arising in individuals who are 50 years or younger, in concordance with other reported study [14]. The mean age of disease get diagnosed was about 47.72, is similar to other studies [14,15,16]. In the recent study invasive ductal carcinoma NST is the commonest histological type of breast carcinoma accounting 95.9% of the total cases, in concordance with other reports [16, 17, 18, 19, 20 & 21] and also consistent with other study showed that, the commonest histological types of the breast cancer cases in Libya, Nigeria and Finland, was non-specific variety of invasive ductal carcinoma [14].…”

Section: Discussionsupporting

confidence: 92%

“…In contrast to other study reported that, the majority of cases (48.5%) diagnosed at earlier stages of cancer (stage I and II). However, the large percentage of patients in advanced stages indicates delayed presentation and late diagnosis in developing countries, and lack of screening mammogram, especially the majority of cases is young age [16]. A study stated that, the main factor in planning of breast cancer treatment is hormone receptor status, where cancers with both ER and PR negative have poorer prognosis than with either ER or PR positive, in addition, ER+, PR+, HER2-tumors have the best prognosis and more likely to response to hormone therapy while ER-PR-HER2+ and ER-PR-HER2-tumors are poorly differentiated, and have poor prognosis, and are least likely to respond to hormone therapy [28].…”

Section: Discussionmentioning

confidence: 99%

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Breast cancer histology and hormonal status characterization in Libyan patients; a sample from middle region

Amshahar

2022

SJMS

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Background: Breast cancer, has increased in developed and developing countries among females, and in Libya, often diagnosed at advanced stage. This study conducted to evaluate histological features and hormonal status of breast carcinoma in Libyan females. Materials and Methods: This retrospective study was performed at Sirte Oncology Centre, Sirte, Libya. Demographic characteristics, such as age, sex, marital status recorded. Histopathology examination provided the histologic type, grade, tumor size, stage, lymph node status, site of metastasis and hormonal status. Data were obtained and analyzed using SPSS software version18.0. Results: A total of 74 breast cancer patients of which 72 (97.3%) were females and 2 (2.7%) were males. Majority of the cases occurred in the 5th decades. Invasive ductal carcinoma of no specific type was the most commonly diagnosed type of breast carcinoma accounting 95.9% of total cases, invasive lobular, ductal and lobular carcinoma and malignant phylloides were the second most common types. Majority of cases (57.4%) diagnosed with grade III tumors and 60 % of cases were found at advanced invasive and metastatic stage of breast cancer. Most of cases showed positive hormonal receptors (both ER and PR positive) (67.2%) while triple negative (ER, PR, and Her2Neu negative) cases were found to be the rarest group (1.6%). Conclusion: Invasive ductal carcinoma was the most common histological type of breast cancer in Libyan patients, commonly diagnosed with a higher grade and at advanced stage. As hormonal status carries a hope of benefit from hormonal treatment, so our study places the significance of early detection, histo-pathological informations and hormonal status in an appropriate treatment strategy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Breast cancer histology and hormonal status characterization in Libyan patients; a sample from middle region

Amshahar

2022

SJMS

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Distribution of molecular breast cancer subtypes among Algerian women and correlation with clinical and tumor characteristics: A population-based study

Cherbal

Gaceb

Mehemmai

et al. 2015

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For the first time, we report the distribution of molecular breast cancer subtypes and their associations with some clinicopathological characteristics in a large cohort of Algerian women. In our current study, the median age of diagnosis for all breast cancer subtypes was younger than the average age in Europe and America. Luminal A was the most common sub- type in our patients followed by TNBC. The proportion of luminal A subtype was lesser than reported in white women with breast cancer in Europe and America. The proportion of TNBC subtype in Algerian women was higher compared with Caucasian women of European ancestry. This study will contribute in developing optimal clinical trial protocols and personalized management strategies for Algerian breast cancer patients.

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Breast cancer in Tripoli/Libya: 1990-2008.

Cited by 2 publications

References 0 publications

Breast cancer histology and hormonal status characterization in Libyan patients; a sample from middle region

Breast cancer histology and hormonal status characterization in Libyan patients; a sample from middle region

Distribution of molecular breast cancer subtypes among Algerian women and correlation with clinical and tumor characteristics: A population-based study

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