Breast cancer in young patients

Sariego, Joaquin; Zrada, S; Byrd, Michael; Matsumoto, Teruo

doi:10.1016/s0002-9610(05)80007-8

Cited by 49 publications

(40 citation statements)

References 13 publications

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“…There are an estimated 100,000 to125, 000 new breast cancer cases detected in India every year and this number of breast cancer cases in India is estimated to double by 2025. 6 The factors that contribute to the international variation in incidence rates of breast cancer largely stem from differences in reproductive and hormonal factors and the availability of early detection services. Reproductive factors which increase the risk of breast cancer include menopausal status of women, nulli-parity, use of postmenopausal hormone therapy, oral contraceptives, failure of breast feeding, late age at first birth etc.…”

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confidence: 99%

Reproductive risk factors and breast cancer: a case control study from rural India

Pratinidhi¹,

Mohite²

2015

Bangladesh J Med Sci

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Abstract:Background: Breast cancer is the most common type of cancer in women and is influenced by reproductive factors perceived by women worldwide. Aims: To identify the reproductive risk factors of breast cancer in newly diagnosed cases and to find out the strength of association of the risk factors with the breast cancer. Material and Methods: A hospital based case-control study was conducted in Satara district, India during year 2009 to 2011 among newly diagnosed cases of breast cancer and matched controls. A total of 434 participants including 217 cases and 217 controls were enrolled by purposive sampling technique from selected hospitals of study area. The information was collected by employing pre-tested questionnaire by utilizing interview method. Statistical Analysis used: Descriptive statistics, Odds ratio and Chi-square test was used to find out strength of association and statistical significant difference. The proportions of cases were higher as compared to the controls with respect to risk factors like unmarried status, nulliparity, history of abortion, post menopausal status, absence of breast feeding and the history of exposure to hormonal contraceptives. The risk of getting breast cancer as indicated by Odds ratio was 8 times higher in unmarried women, 2.8 times in nulliparous women, 2.4 times with post menopausal status, 10.4 times with absence of breast feeding, 1.5 times with exposure to hormonal contraceptives and 4.5 times with history of ovarian disease respectively. Conclusion: The reproductive risk factors such as unmarried status of women, nulliparity, menopause, absence of breast feeding, history of ovarian disease and use of contraceptives were strongly associated with breast cancer. Introduction:Breast cancer is the most common type of cancer in women worldwide. It is reflected as an important public health problem for adult women residing in developing countries like India.1 Breast cancer alone accounts for 16% of all female cancers 2,3 with 14% mortality, of which about half of the cases and 60% deaths are estimated to occur in economically developing countries.4 It is estimated that by 2030 the global burden of breast cancer will increase to over 2 million new cases per year.

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Reproductive risk factors and breast cancer: a case control study from rural India

Pratinidhi¹,

Mohite²

2015

Bangladesh J Med Sci

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“…Breast cancer initiates from mammary epithelial cells located in the lobules or ducts of the breast (Sariego, 2010). Despite a relatively lower incidence of breast cancer in Asian countries compared to Western countries (Jemal et al, 2006), the incidence of breast cancer has dramatically increased over the past 30 years in Chinese urban women (Fan et al, 2009).…”

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Characterization of spontaneous breast tumor in tree shrews (<I>Tupaia belangeri chinenesis</I>)

Xia¹,

Wang²,

Zhang³

et al. 2013

Zoological Research

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Breast cancer is a common malignant tumor. It is essential to develop suitable animal models for discovering novel preventive and therapeutic approaches. Tree shrews (Tupaia belangeri chinensis) have a closer evolutionary relationship with humans than do rodents, which have been widely used in laboratory research. Spontaneous breast tumors were identified in tree shrews in 1960s; however, no detailed studies about tree shrew breast tumors have been conducted to date. Here, we characterized a spontaneous breast tumor from tree shrews by Haematoxylin Eosin (H&E) staining. This tumor was identified as a papillary tumor. Immunohistochemical staining (IHC) for progesterone receptor (PR), Ki-67 and cleaved caspase-3 showed that tumor cells were positive for PR, highly proliferative, and less apoptotic compared to normal breast epithelial cells. Thus, the spontaneous tumor of tree shrew is very close to human papillary tumors in terms of morphology and pathology and we concluded that tree shrew may be a suitable animal model for breast cancer research.

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“…It was also the case of our patient, where four lymph nodes were invaded. Regarding the histological type of carcinoma occurring in young women in most of the reported cases the ductal infiltrating type prevails, and there are rare cases of lobular infiltrating carcinoma, as considered by pathologists as always having a low degree of cell differentiation (stage III) [1,4,8,17,29].…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in Women under 30 is Highly Aggressive with Extremely Low Frequency: a Case Report

Păun¹

2014

SOJI

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SOJ ImmunologyOpen Access Case Report edema of the skin, showing a thick consistency in the central and lower quadrants, being sensitive to touch. 3 palpable lymph nodes were found in the right armpit, having a diameter between 1 cm and 2.5 cm, with a thick consistency. Ultrasonography revealed the presence of a non-homogenous glandular tissue of the right breast, with four solid nodes, non-homogeneous, with unclearly defined calcifications, vascular signal of low strength visible centrally and peripherally, highly suggestive of their equivocal character; the nodes had the following size: 2.8/2 cm, 1.7/1.3 cm, 1.5/1/0.1 cm and 1/0.7 cm, in the right armpit lymph nodes were found, having diameters of max = 20 mm, with non-differentiated sinus and periphery, and arterial vascular signal of low strength. Bone scintigraphy did not reveal the presence of bone lesions.Laboratory tests indicated: Hb = 13.2 g%, WBC = 11720/ mm 3 , Urea = 36 mg%, Bt = 0.26 mg % and CA 15-3 = 40.3 U. Chest X-ray revealed no damage evolution. On November 15, 2008 axillary lymph node biopsy was done. The histopathological test confirmed a poorly differentiated massive metastatic carcinoma. The immunohistochemical test revealed the following: HER2-negative, ER-negative, PGR-positive in less than 10% of the tumor cells and SR-2 (positive). The diagnosis upon discharge was: breast cancer (inflammatory carcinoma)-stage III B (T4dN2M0) [3]. In January 2009 the patient was referred to the Oncology unit where she was given chemotherapy in 5 sequences (DOCETAXEL and EPIDOXORUBICIN) [4,5]. The response to chemotherapy was partial: the erythema wore off and the skin edema was reduced (yet a slight peau d'orange was still present). Also a right axillary lymphadenopathy relic having a diameter of 1.5 cm persisted. Under the circumstances, it was decided to change the regimen by administering EPIDOXORUBICIN + 5 FLUOROURACIL + CYCLOPHOSPHAMIDE [4,5] in 4 sequences, followed by radiotherapy 50 Gy, the evolution still being favorable (disappearance of skin edema with the involution of mammary lymph nodes and axillary adenopathy). On 22 July 2009 surgery took place in the form of mastectomy with full axillary dissection. AbstractBreast cancer occurrence is increasing worldwide; however, patients under 30 years of age who present with this condition are scarce. Using as a pretext, the "chance" to encounter a case of breast cancer patient less than 30 years of age in a hospital setting, in conjunction with the relatively few data in the literature on the topic, the current paper attempts to point out some of the features of breast carcinoma occurring in this category of patients. Basically, the paper highlights a very important aspect, namely that breast carcinoma in young women is more aggressive and shows a reserved prognosis, translated as a 5-year lower survival rate and a higher percentage of relapse following therapy compared to women in perimenopause or to elderly ones.

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Breast cancer in young patients

Cited by 49 publications

References 13 publications

Reproductive risk factors and breast cancer: a case control study from rural India

Reproductive risk factors and breast cancer: a case control study from rural India

Characterization of spontaneous breast tumor in tree shrews (<I>Tupaia belangeri chinenesis</I>)

Breast Cancer in Women under 30 is Highly Aggressive with Extremely Low Frequency: a Case Report

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