Breast Cancer in Young Women from a Low Risk Population in Nepal

Thapa, Bibhusal; Singh, Yogendra; Sayami, Prakash; Shrestha, Upendra Thapa; Sapkota, Ranjan; Sayami, Gita

doi:10.7314/apjcp.2013.14.9.5095

Cited by 38 publications

(46 citation statements)

References 30 publications

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“…Furthermore, oncologists have reached an agreement that breast cancer in young patients often show more aggressive biologic behavior, such as advanced stage, less ER positive expression, higher histological grade and more peritumoral vascular invasion. All these features indicate a bad prognosis of young patients (Anders et al, 2008;Cancello et al, 2010;Thapa et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Mammograghic Findings and Clinical/Pathologic Features in Women with Small Invasive Breast Carcinomas

Li¹,

Xu²,

Wang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Correlation Between Mammograghic Findings and Clinical/Pathologic Features in Women with Small Invasive Breast Carcinomas

Li¹,

Xu²,

Wang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…4 The familial history of breast cancer and mutation of tumor suppressor genes BRCA1, BRCA2 and p53 increases risk of breast cancer. 1 Alcohol consumption, high dietary fat intake, obesity, overweight, diabetes mellitus and physical inactivity has induced breast cancer incidence.…”

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confidence: 99%

Histopathological evaluation of carcinoma of breast

Pathak

Jha²,

Neupane³

et al. 2016

J Pathol Nep

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Background: Carcinoma of breast has become the major public health problem among females in developing as well as developed countries. In Nepal it comprises 6% of total cancers cases and often diagnosed at advanced stage. Surgical removal or modiied radical mastectomy (MRM) is the most commonly used tools for disease management. The objective of this study is to identify the clinical, macroscopic and microscopic features of MRM specimens. Materials and Methods:This prospective cross-sectional study was carried out at Department of Pathology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal. Macroscopic and microscopic examination provided the tumor size, stage, grade, lymph node status, lympho-vascular invasion and perineural invasion. Data were collected and analyzed using SPSS 16. Results:The study comprised 112 breast cancer patients of which 109 (97.3%) were females and 3 (2.7%) were males. Invasive ductal carcinoma no speciic type was the most common type of breast carcinoma. (84 cases) accounting 75% of total cases. Carcinoma with medullary features was second most common (6 cases) comprising 5.4% cases followed by lobular, papillary, apocrine, mucinous and NST mixed types. Grade II tumors were most frequent grade observed in 76.79% cases followed by Grade I (12.50%) and Grade III (10.71%). Conclusion:As a conclusion invasive ductal carcinoma was the most common histological type breast cancer and the tumors were found at T2 and N3 stage i.e maximum at grade II. Our study provides prognostic signiicance of histo-pathological information in breast cancer management. ABSTRACT INTRODUCTIONBreast cancer is the most frequently occurring cancer among women in the developed as well as developing Pathak R 1 , Jha A 2 , Neupane PR 3 , Chalise S 2 , Basnyat AS 2 1 Department of Pathology, Nepal Medical college Teaching Hospital, Jorpati Kathmandu, Nepal. 2 Department of Pathology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal 3 Department of Surgery, Bhaktapur Cancer Hospital, Bhaktapur, Nepal. countries and it has become the major public health problem worldwide with nearly 1.7 million newly diagnosed cases in 2012 representing 25% of all female cancers. 1,2 Among Nepalese women, breast cancer is the second most common type of cancer accounting 6% of total cancers in Nepal. 3 In Nepal, more than one quarter of the breast cancer is diagnosed in young female and many being diagnosed at an advanced stage with tumors showing more aggressive

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“…More than one quarter of the BC diagnosed in Nepal is inyoung female with familial history of breast cancer, early pregnancy, longer lactation and estrogen exposureand tumors oftenshowing aggressive biological behaviors [4][5][6].Among chemotherapeutic agents, anthracyclines based treatment regime were reported to cause cardiotoxicity by increasing intramyocardial free radical production, lipid alterationsanddecreasing antioxidant level by adversely affecting dietary intake and nutritional status of the patients [7][8][9].Cancer cells reprogram their enzyme and signaling pathways to meet higher need of building blocks required for abnormal proliferation and their survival [13][14][15][16][17]. An association between altered lipids metabolism, diabetes, cardiovascular riskand other metabolic dysregulation with chemotherapy has been identified but underlying mechanismis not clear.…”

Section: Introductionmentioning

confidence: 99%